Unstimulated salivary flow and oral streptococci in pediatric patients with hematological tumors: A longitudinal study

Araújo, Elza Cristina Farias de; Costa, Raphael Cavalcante; Ribeiro, Isabella Lima Arrais; Almeida, Leopoldina de Fátima Dantas de; Serpa, Eliane Batista de Medeiros; Valença, Ana Maria Gondim

doi:10.1111/scd.12628

Cited by 2 publications

(2 citation statements)

References 46 publications

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“…Poor oral hygiene can negatively impact the systemic condition of patients undergoing chemotherapy or bone marrow transplantation. 21 Furthermore, chemotherapy in children with hematological tumors can lead to dysbiosis of the oral microbiota 22 and a higher prevalence of gingivitis than the control group matched for age, sex, and caries status. 23 Parra et al 24 observed a significant reduction in the Silness and Löe plaque index (p = .000) and a slight improvement in the Silness and Löe gingival index after chemotherapy treatment in children with ALL.…”

Section: Discussionmentioning

confidence: 99%

“…Poor oral hygiene can negatively impact the systemic condition of patients undergoing chemotherapy or bone marrow transplantation 21 . Furthermore, chemotherapy in children with hematological tumors can lead to dysbiosis of the oral microbiota 22 and a higher prevalence of gingivitis than the control group matched for age, sex, and caries status 23 . Parra et al 24 .…”

Section: Discussionmentioning

confidence: 99%

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A hospital‐based oral health education program impacts in pediatric cancer patients—A pilot study

Sampaio

Bezerra

Santos

et al. 2023

Special Care in Dentistry

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ObjectivesTo assess the impact of an oral health education and preventive program (OHEPP) for pediatric cancer patients.MethodsThis was a single‐arm study with 27 children and adolescents undergoing antineoplastic treatments. Patients were followed up for 10 weeks, and their oral health conditions were evaluated using the Modified Gingival Index (MGI), Visible Plaque Index (VPI), and the modified Oral Assessment Guide (OAG). Audiovisual resources, storytelling, and ludic instruments were used to provide oral health education to patients and parents/caregivers.ResultsThe patients’ mean age was 9.41 (±4.49) years, and acute lymphoblastic leukemia was the most prevalent diagnosis (22.2%). Mean MGI and VPI values were 0.82 (±0.59) and 54.11% (±19.92%) at baseline and 0.33 (±0.29) and 19.83% (± 11.47%) after 10 weeks, respectively (p < .05). The mean OAG score was 9.51 (±2.54) and 36 cases (19.8%) of severe oral mucositis (SOM) were documented. Patients with higher MGI were more likely to develop SOM.ConclusionThe OHEPP had a positive impact on pediatric patients undergoing cancer therapy by improving their periodontal health, reducing biofilm accumulation, and preventing the development of OM lesions.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

A hospital‐based oral health education program impacts in pediatric cancer patients—A pilot study

Sampaio

Bezerra

Santos

et al. 2023

Special Care in Dentistry

Self Cite

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Reduced Salivary Flow Rate and Increased Caries Susceptibility in Italian Children in Remission from Hematological Malignancy

Defabianis,

Bello,

Romano

2023

Applied Sciences

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Salivary gland dysfunction is an underestimated oral late effect of chemotherapy in childhood cancer survivors (CCS). Therefore, the aim of this cross-sectional study was to assess the salivary functioning and dental caries experience in Italian CSSs and age- and gender-matched healthy children. A total of 32 children (15 females and 17 males, age range 6–14 years) in remission from hematological malignancy and 32 healthy controls were compared for salivary parameters (stimulated whole salivary flow rate, pH, and buffer capacity) and presence of carious lesions in the primary and permanent dentition using the dmft/DMFT indexes. Significantly lower stimulated whole saliva (SWS) and pH were observed in CSS than in healthy pediatric patients (both p < 0.001), together with a higher prevalence of carious lesions on both the deciduous (p = 0.002) and permanent teeth (p = 0.015). SWS was more severely impaired in children treated with chemotherapy before 5 years of age (p < 0.001) and, in spite of the tendency to improve over time, low SWS was still observed after 5–9 years of disease remission. According to the present data, chemotherapy has a detrimental effect on salivary gland functioning, which would seem to maintain up to 9 years after antineoplastic treatment.

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Unstimulated salivary flow and oral streptococci in pediatric patients with hematological tumors: A longitudinal study

Cited by 2 publications

References 46 publications

A hospital‐based oral health education program impacts in pediatric cancer patients—A pilot study

A hospital‐based oral health education program impacts in pediatric cancer patients—A pilot study

Reduced Salivary Flow Rate and Increased Caries Susceptibility in Italian Children in Remission from Hematological Malignancy

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