Integrated multi-wavelength fluorescence sensors

Starikov, D.; Benkabou, F.; Medelci, N.; Bensaoula, A.

doi:10.1109/sficon.2002.1159798

Cited by 7 publications

(8 citation statements)

References 7 publications

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“…Two macro-scale devices that demonstrate the use of spectrally selective detectors for fluorescence sensing can be found in the literature; this concept has not yet been used in an integrated device. The first, by Starikov et al 119 used several MBE-grown diodes in order to obtain a wide range of spectral characteristics. This work is remarkable because it also made use of the detectors as light sources.…”

Section: Demonstrated Devicesmentioning

confidence: 99%

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Optical filtering technologies for integrated fluorescence sensors

2007

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Numerous approaches have been taken to miniaturizing fluorescence sensing, which is a key capability for micro-total-analysis systems. This critical, comprehensive review focuses on the optical hardware required to attenuate excitation light while transmitting fluorescence. It summarizes, evaluates, and compares the various technologies, including filtering approaches such as interference filters and absorption filters and filterless approaches such as multicolor sensors and light-guiding elements. It presents the physical principles behind the different architectures, the state-of-the-art micro-fluorometers and how they were microfabricated, and their performance metrics. Promising technologies that have not yet been integrated are also described. This information will permit the identification of methods that meet particular design requirements, from both performance and integration perspectives, and the recognition of the remaining technological challenges. Finally, a set of performance metrics are proposed for evaluating and reporting spectral discrimination characteristics of integrated devices in order to promote side-by-side comparisons among diverse technologies and, ultimately, to facilitate optimized designs of micro-fluorometers for specific applications.

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Section: Demonstrated Devicesmentioning

confidence: 99%

“…One its to combine interference or spectrally selective filtering with additional absorption filtering, as done in Starikov. 119 Another is to combine these approaches with light separation methods that employ positioning, micro-optical elements, and/or light guiding to achieve the bulk of the rejection.…”

Section: Summary Of Achieved Device Performancementioning

confidence: 99%

Optical filtering technologies for integrated fluorescence sensors

2007

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“…rodents) and combined with a wireless telemetry system, enable continuous molecular monitoring in freely-moving animal subjects. Indeed several miniature fluorescence sensing systems have already been developed, but mainly for lab-on-achip or microfluidic-based applications [5][6][7][8][9][10][11][12]. These sensors incorporate a light source, such as an LED or a laser, with a nearby photodetector and a fluorescence emission filter.…”

Section: Introductionmentioning

confidence: 99%

Implantable semiconductor biosensor for continuous in vivo sensing of far-red fluorescent molecules

O’Sullivan¹,

Munro²,

Parashurama³

et al. 2010

Opt. Express

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We have fabricated miniature implantable fluorescence sensors for continuous fluorescence sensing applications in living subjects. These monolithically integrated GaAs-based sensors incorporate a 675 nm vertical-cavity surface-emitting laser (VCSEL), a GaAs PIN photodiode, and a fluorescence emission filter. We demonstrate high detection sensitivity for Cy5.5 far-red dye (50 nanoMolar) in living tissue, limited by the intrinsic background autofluorescence. These low cost, sensitive and scalable sensors are promising for long-term continuous monitoring of molecular dynamics for biomedical studies in freely moving animals.

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“…Using these norm spectra and actual five-point excitation spectrum of a water sample, a separate estimate of the respective Chl concentration was rapidly obtained for each algal group. An integrated multiwavelength fluorescence sensors prototype was fabricated by Starikov et al [64] using solid-state components. Those researchers used eight LEDs with different colors from UV to red, which were arranged in a circular design and mounted in light tight housing.…”

Section: Lasersmentioning

confidence: 99%

“…fluorometers because of their good response time, small size, and low cost, though photodiodes have higher noise and interference immunity than PMT. The development of PD technique has promoted and accelerated the performance of in situ fluorometers [64]. Additionally, there exist some techniques to improve the SNR.…”

Section: Photodiode Silicon Photodiodes Are Suitable For In Situmentioning

confidence: 99%

Development ofIn SituSensors for Chlorophyll Concentration Measurement

Zeng

2015

Journal of Sensors

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Chlorophyll fluorescence measurement is a sensitive and effective method to quantify and analyze freshwater and sea water phytoplanktonin situ. Major improvements in optical design, electronic technology, and calibration protocol have increased the accuracy and reliability of the fluorometer. This review briefly describes the improvement of probe design, excitation light sources, detectors, and calibrations ofin situfluorometers. Firstly, various optical designs for increasing the efficiency of fluorescence measurement are discussed. Next, the development of electronic technology to meet and improvein situmeasurement, including various light sources, detectors, and corresponding measurement protocols, is described. In addition, various calibration materials, procedures, and methods are recommended for different kinds of water. The conclusion discusses key trends and future perspectives forin situfluorescence sensors.

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Integrated multi-wavelength fluorescence sensors

Cited by 7 publications

References 7 publications

Optical filtering technologies for integrated fluorescence sensors

Optical filtering technologies for integrated fluorescence sensors

Implantable semiconductor biosensor for continuous in vivo sensing of far-red fluorescent molecules

Development ofIn SituSensors for Chlorophyll Concentration Measurement

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