Integrated lecithin–bile salt nanovesicles as a promising approach for effective skin delivery of luteolin to improve UV-induced skin damage in Wistar Albino rats

Abbas, Haidy; Sayed, Nesrine S El; Ali, Maged; Elsheikh, Manal A

doi:10.1016/j.colsurfb.2021.112299

Cited by 16 publications

(15 citation statements)

References 36 publications

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“…The integration of the anionic SDC with phospholipid vesicle membranes increased net negative charge, with high repulsive force between vesicles. These results agree with the previously reported data by Abbas et al [ 36 ], Abdelalim et al [ 32 ], and El Naggar et al [ 42 ].…”

Section: Resultssupporting

confidence: 94%

“…Thin-film hydration technique was adopted to prepare different formulations of BS, with PBS as the hydrating medium PBS (pH 7.4). SDC was selected as a bile salt in BS preparation based on its previously reported permeation enhancing effects in other transdermal preparations [ 33 , 34 , 35 , 36 ]. In this study, a crude SPR extract was used rather than a pure extract of separate active constituents because SPR contains several nutrients that exhibit pharmacological activity [ 37 ].…”

Section: Resultsmentioning

confidence: 99%

“…This may be attributed to the surface-active properties of SDC, as it might integrate into the lipid bilayer membrane enhancing the solubility of SPR. Furthermore, the incorporation of the hydrophobic SDC in the BS structure resulted in an effective intermolecular association of the hydrophobic drug SPR inside the hydrophobic tails of the phospholipid bilayer, producing high EE% [ 36 ]. Consistently, El-Nabarawi et al [ 33 ] reported that BS prepared with SDC had the highest EE% value compared with other formulations prepared using other types of bile salts of higher HLB values [ 33 ].…”

Section: Resultsmentioning

confidence: 99%

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Novel Siprulina platensis Bilosomes for Combating UVB Induced Skin Damage

et al. 2022

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The recent interest in bioactive compounds from natural sources has led to the evolution of the skin care industry. Efforts to develop biologically active ingredients from natural sources have resulted in the emergence of enhanced skin care products. Spirulina (SPR), a nutritionally enriched cyanobacteria-type microalga, is rich in nutrients and phytochemicals. SPR possesses antioxidant, immunomodulatory, and anti-inflammatory activities. Spirulina-loaded bilosomes (SPR-BS), a novel antiaging drug delivery system, were designed for the first time by incorporation in a lecithin–bile salt-integrated system for bypassing skin delivery obstacles. The optimized BS had good entrapment efficiency, small particle size, optimal zeta potential, and sustained drug release pattern. Blank and SPR-loaded BS formulations were safe, with a primary irritancy index of <2 based on the Draize test. In vivo tests were conducted, and photoprotective antiaging effects were evaluated visually and biochemically by analyzing antioxidant, anti-inflammatory, and anti-wrinkling markers following ultraviolet (UV) B irradiation. Results of biochemical marker analysis and histopathological examination confirmed the superior antiaging effect of SPR-BS compared with SPR. Thus, SPR-loaded BS is a promising nanoplatform for SPR delivery, can be used for treating UV-induced skin damage, and offers maximum therapeutic outcomes.

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Section: Resultssupporting

confidence: 94%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Novel Siprulina platensis Bilosomes for Combating UVB Induced Skin Damage

et al. 2022

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“… 37 Six random non-overlapping fields from each sample were totally scanned and analyzed for obtaining the mean area percentage of segmented dermal collagen in Masson’s trichrome stained section. 38 All data and micrographs were obtained by using a Full HD microscopic imaging system operated by using Leica application module (Leica Microsystems GmbH, Germany) for histological analysis.…”

Section: Methodsmentioning

confidence: 99%

Gentiopicroside PLGA Nanospheres: Fabrication, in vitro Characterization, Antimicrobial Action, and in vivo Effect for Enhancing Wound Healing in Diabetic Rats

Almukainzi

El‐Masry

Negm

et al. 2022

IJN

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Purpose Gentiopicroside (GPS), an adequate bioactive candidate, has a promising approach for enhancing wound healing due to its antioxidant and antimicrobial properties. Its poor aqueous solubility negatively affects oral absorption accompanied by low bioavailability due to intestinal/hepatic first-pass metabolism. Our aim in this study is to fabricate GPS into appropriate nanocarriers (PLGA nanospheres, NSs) to enhance its solubility and hence its oral absorption would be improved. Methods Normal and ODS silica gel together with Sephadex LH20 column used for isolation of GPS from Gentiana lutea roots. Crude GPS would be further processed for nanospheres fabrication using a single o/w emulsion solvent evaporation technique followed by in vitro optimization study to examine the effect of two formulation variables: polymer (PLGA) and stabilizer (PVA) concentrations on the physical characterizations of prepared NSs. Possible GPS-PLGA chemical and physical interactions have been analyzed using Fourier-transform infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC). The optimum GPS-PLGA NSs have been chosen for antimicrobial study to investigate its inhibitory action on Staphylococcus aureus compared with unloaded GPS NSs. Also, a well-designed in vivo study on streptozotocin-induced diabetic rats has been performed to examine the wound healing effect of GPS-PLGA NSs followed by histological examination of wound incisions at different day intervals throughout the study. Results The optimum GPS PLGA NSs (F5) with well-controlled particle size (250.10±07.86 nm), relative high entrapment efficiency (83.35±5.71), and the highest % cumulative release (85.79±8.74) have increased the antimicrobial activity as it exhibited a higher inhibitory effect on bacterial growth than free GPS. F5 showed a greater enhancing impact on wound healing and a significant stimulating effect on the synthesis of collagen fibers compared with free GPS. Conclusion These findings demonstrate that loading GPS into PLGA NSs is considered a promising strategy ensuring optimum GPS delivery for potential management of wounds.

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“…According to Abbas et al ( 2021 ), six random non-overlapping microscopic fields from each sample per group were scanned and then analyzed for obtaining the mean area percentage of segmented dermal collagen fibers contents in Masson’s trichrome stained section. All data and micrographs were obtained by using a Full HD microscopic imaging system operated by using the Leica application module for histological analysis.…”

Section: Methodsmentioning

confidence: 99%

Appraisal on the Wound Healing Potential of Deverra tortuosa DC. and Deverra triradiata Hochst Essential Oil Nanoemulsion Topical Preparation

et al. 2022

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Deverra tortuosa (Desf.) DC. and Deverra. triradiata Hochst. ex Bioss are perennial desert shrubs widely used traditionally for many purposes and they are characteristic for their essential oil. The objective of the present study was to investigate the in vivo wound healing activity of the essential oil (EO) of D. tortuosa and D. triradiata through their encapsulation into nanoemulsion. EO nanoemulsion was prepared using an aqueous phase titration method, and nanoemulsion zones were identified through the construction of phase diagrams. The EO was prepared by hydrodistillation (HD), microwave-assisted hydrodistillation (MAHD), and supercritical fluid extraction (SFE) and analyzed using GC/MS. D. tortuosa oil is rich in the non-oxygenated compound, representing 74.54, 73.02, and 41.19% in HD, MADH, and SFE, respectively, and sabinene represents the major monoterpene hydrocarbons. Moreover, D. triradiata is rich in oxygenated compounds being 69.77, 52.87, and 61.69% in HD, MADH, and SFE, respectively, with elemicin and myristicin as major phenylpropanoids. Topical application of the nanoemulsion of D. tortuosa and D. triradiata (1% or 2%) exhibited nearly 100% wound contraction and complete healing at day 16. Moreover, they exhibit significant antioxidant and anti-inflammatory effects and a significant increase in growth factors and hydroxyproline levels. Histopathological examination exhibited complete re-epithelialization accompanied by activated hair follicles and abundant collagen fibers, especially at a concentration of 2%. Therefore, the incorporation of the two Deverra species into nanoemulsion could professionally endorse different stages of wound healing.

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Integrated lecithin–bile salt nanovesicles as a promising approach for effective skin delivery of luteolin to improve UV-induced skin damage in Wistar Albino rats

Cited by 16 publications

References 36 publications

Novel Siprulina platensis Bilosomes for Combating UVB Induced Skin Damage

Novel Siprulina platensis Bilosomes for Combating UVB Induced Skin Damage

Gentiopicroside PLGA Nanospheres: Fabrication, in vitro Characterization, Antimicrobial Action, and in vivo Effect for Enhancing Wound Healing in Diabetic Rats

Appraisal on the Wound Healing Potential of Deverra tortuosa DC. and Deverra triradiata Hochst Essential Oil Nanoemulsion Topical Preparation

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