Integrated evaluation of malonyl ginsenosides, amino acids and polysaccharides in fresh and processed ginseng

Wan, Jianwei; Fan, Yong; Yu, Qing-Tao; Ge, Yihe; Yan, Chen-Pu; Alolga, Raphael N.; Li, Ping; Ma, Zhonghua; Qi, Lian‐Wen

doi:10.1016/j.jpba.2014.11.014

Cited by 73 publications

(54 citation statements)

References 30 publications

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“…The important pathway identified from Asian ginseng and American ginseng may be useful for further mechanism analysis and can also help to explore new therapeutic effects or action targets so as to broad application of Asian ginseng and American ginseng. It is notable that several fatty acids and amino acids which are primary metabolites in Asian ginseng and American ginseng414243 were highlighted as the differential metabolites in response to the treatments of two ginsengs, the effect of exogenous metabolites should take into consideration in future study. However, there still are some limitations on this study.…”

Section: Discussionmentioning

confidence: 99%

Distinct urine metabolome after Asian ginseng and American ginseng intervention based on GC-MS metabolomics approach

Yang

et al. 2016

Sci Rep

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Ginseng occupies a prominent position in the list of best-selling natural products worldwide. Asian ginseng (Panax ginseng) and American ginseng (Panax quinquefolius) show different properties and medicinal applications in pharmacology, even though the main active constituents of them are both thought to be ginsenosides. Metabolomics is a promising method to profile entire endogenous metabolites and monitor their fluctuations related to exogenous stimulus. Herein, an untargeted metabolomics approach was applied to study the overall urine metabolic differences between Asian ginseng and American ginseng in mice. Metabolomics analyses were performed using gas chromatography-mass spectrometry (GC-MS) together with multivariate statistical data analysis. A total of 21 metabolites related to D-glutamine and D-glutamate metabolism, glutathione metabolism, TCA cycle and glyoxylate and dicarboxylate metabolism, differed significantly under the Asian ginseng treatment; 34 metabolites mainly associated with glyoxylate and dicarboxylate metabolism, TCA cycle and taurine and hypotaurine metabolism, were significantly altered after American ginseng treatment. Urinary metabolomics reveal that Asian ginseng and American ginseng can benefit organism physiological and biological functions via regulating multiple metabolic pathways. The important pathways identified from Asian ginseng and American ginseng can also help to explore new therapeutic effects or action targets so as to broad application of these two ginsengs.

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Section: Discussionmentioning

confidence: 99%

Distinct urine metabolome after Asian ginseng and American ginseng intervention based on GC-MS metabolomics approach

Yang

et al. 2016

Sci Rep

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“…The patient died from physical debilitation accounted for one-tenth to two-tenths, while the patient died of disease accounted for eight-tenths to nine-tenths. Ginseng specializes in nourishing the weak body and is not good at conquering the disease [8]. Whether or not the pathogens have been wiped out, sickness or institutional weakness for a long time, or wealth, doctors use Ginseng for sure.…”

Section: Differences In Chemical Composition and Pharmacological Effectsmentioning

confidence: 99%

Brief Description of the Difference between Ginseng and Codonopsis

Zhang¹

2017

Proceedings of the 2016 7th International Conference on Education, Management, Computer and Medicine (EMCM 2016)

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“…The crude polysaccharide was dissolved in distilled water and was fractionated on a DEAE-cellulose-52 column (2.6 × 40 cm, from Whatman) equilibrated by distilled water, with a linear gradient from 0 to 0.5 M NaCl at a flow rate of 0.5 mL/min. All of the fractions were assayed for carbohydrate content by the phenolsulfuric acid method (12), and two sharp peaks were pooled, dialyzed, concentrated, and further purified by a Sephadex G-100 column (1.6 × 70 cm, from Whatman) eluting with distilled water at a flow rate of 0.3 mL/min. The polysaccharide fractions were collected, dialyzed, and lyophilized.…”

Section: Extraction Isolation and Purification Of Polysaccharidesmentioning

confidence: 99%

Structural elucidation and <i>in vitro</i> antioxidant activities of a new heteropolysaccharide from <i>Litchi chinensis </i>

Hu¹,

Wang

Jing³

et al. 2015

DD&T

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Two polysaccharides, LCP70S-1 and LCP70W, were isolated from the pulp tissues of Litchi chinensis by anion-exchange chromatography and gel-filtration chromatography, while the structure of LCP70S-1 was elucidated and its physico-chemical properties was analyzed. The results demonstrated that LCP70S-1 is composed of L-rhamnose, L-arabinose and D-galactose in the ratio of 1.06:6.39:4.21, and the main chain of the heteropolysaccharide possess (1→3,6)-linked galactopyranosyl branches at O-6. The three branches consist of (1→3)-linked rhamnopyranosyl residues, (1→3,6)-linked galactopyranosyl and (1→5)-linked arabinopyranosyl residues, and terminated with (1→)-linked arabinopyranosyl residues, respectively. The two polysaccharides were further evaluated with 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activities and their reducing power in vitro. The results showed that LCP70W and LCP70S-1 possessed significant antioxidant activities, especially for LCP70S-1. As such, LCP70S-1 could potentially serve as an antioxidant and would value further study for human healthcare.

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Integrated evaluation of malonyl ginsenosides, amino acids and polysaccharides in fresh and processed ginseng

Cited by 73 publications

References 30 publications

Distinct urine metabolome after Asian ginseng and American ginseng intervention based on GC-MS metabolomics approach

Distinct urine metabolome after Asian ginseng and American ginseng intervention based on GC-MS metabolomics approach

Brief Description of the Difference between Ginseng and Codonopsis

Structural elucidation and <i>in vitro</i> antioxidant activities of a new heteropolysaccharide from <i>Litchi chinensis </i>

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