Structural elucidation and &lt;i&gt;in vitro&lt;/i&gt; antioxidant activities of a new heteropolysaccharide from &lt;i&gt;Litchi chinensis &lt;/i&gt;

Hu, Xuqiao; Wang, Jinlin; Jing, Yongshuai; Song, Liyan; Zhu, Jianhua; Cui, Xinlu; Yu, Rongmin

doi:10.5582/ddt.2015.01022

Cited by 9 publications

(2 citation statements)

References 26 publications

(25 reference statements)

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“…The fruit is known for its good taste and nutritional properties [ 3 ]. Recent studies have shown that litchi pulp (mesocarp) contains bioactive compounds, including polysaccharides with strong antioxidant activities [ 6 , 7 ]. In addition, Huang et al have also provided evidence that litchi pulp displays anti-tumor and immunomodulatory effects both in vitro and in vivo [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Sicilian Litchi Fruit Extracts Induce Autophagy versus Apoptosis Switch in Human Colon Cancer Cells

et al. 2018

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Litchi chinensis Sonnerat is a tropical tree whose fruits contain significant amounts of bioactive polyphenols. Litchi cultivation has recently spread in Sicily where the climate conditions are particularly favorable for this crop. Recent findings have shown that Litchi extracts display anti-tumor and pro-apoptotic effects in vitro, but the precise underlying mechanisms have not been fully elucidated. In this study, we report for the first time the effects of Sicilian litchi fruit extracts on colon cancer cells. The results indicated that litchi exocarp, mesocarp and endocarp fractions reduce the viability and clonogenic growth of HT29 cells. These effects were due to cell cycle arrest in the G2/M phase followed by caspase-dependent cell death. Interestingly, litchi exocarp and endocarp triggered a precocious autophagic response (16–24 h), which was accompanied by an increase in the level of autophagy related 1/autophagy activating kinase 1 (ATG1/ULK1), beclin-1, microtubule associated protein 1 light chain 3 (LC3)-II and p62 proteins. Autophagy inhibition by bafilomycin A1 or beclin-1 silencing increased cell death, thus suggesting that autophagy was initially triggered as a pro-survival response. Significant effects of Litchi extracts were also observed in other colon cancer cells, including HCT116 and Caco-2 cells. On the other hand, differentiated Caco-2 cells, a model of human enterocytes, appeared to be insensitive to the extracts at the same treatment conditions. High-Performance Liquid Chromatography–Electrospray Ionization-Quadrupole-Time-Of-Flight HPLC/ESI/Q-TOF evidenced the presence of some polyphenolic compounds, specifically in exocarp and endocarp extracts, that can account for the observed biological effects. The results obtained suggest a potential therapeutic efficacy of polyphenolic compounds purified from Sicilian Litchi fractions for the treatment of colon cancer. Moreover, our findings indicate that modulation of autophagy can represent a tool to improve the effectiveness of these agents and potentiate the anti-tumor response of colon cancer cells.

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Section: Introductionmentioning

confidence: 99%

Sicilian Litchi Fruit Extracts Induce Autophagy versus Apoptosis Switch in Human Colon Cancer Cells

et al. 2018

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“…This portion is enriched with a blend of components with interesting nutraceutical properties. Specifically, many studies have shown that Litchi pulp contains a great percentage of bioactive polysaccharides with strong antioxidant activity [ 19 , 20 , 21 ]. In addition, these compounds display antitumor and immunomodulatory effects in vitro [ 22 ].…”

Section: Antitumor Properties Of Litchi Pulp-derived Componentsmentioning

confidence: 99%

Litchi chinensis as a Functional Food and a Source of Antitumor Compounds: An Overview and a Description of Biochemical Pathways

et al. 2017

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Litchi is a tasty fruit that is commercially grown for food consumption and nutritional benefits in various parts of the world. Due to its biological activities, the fruit is becoming increasingly known and deserves attention not only for its edible part, the pulp, but also for its peel and seed that contain beneficial substances with antioxidant, cancer preventive, antimicrobial, and anti-inflammatory functions. Although literature demonstrates the biological activity of Litchi components in reducing tumor cell viability in in vitro or in vivo models, data about the biochemical mechanisms responsible for these effects are quite fragmentary. This review specifically describes, in a comprehensive analysis, the antitumor properties of the different parts of Litchi and highlights the main biochemical mechanisms involved.

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Indian Tropical Fruits and Their Bioactive Compounds Against Human Diseases

Laldinchhana¹,

Lalrengpuii

Ray

et al. 2020

Plant-Derived Bioactives

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Structural elucidation and <i>in vitro</i> antioxidant activities of a new heteropolysaccharide from <i>Litchi chinensis </i>

Cited by 9 publications

References 26 publications

Sicilian Litchi Fruit Extracts Induce Autophagy versus Apoptosis Switch in Human Colon Cancer Cells

Sicilian Litchi Fruit Extracts Induce Autophagy versus Apoptosis Switch in Human Colon Cancer Cells

Litchi chinensis as a Functional Food and a Source of Antitumor Compounds: An Overview and a Description of Biochemical Pathways

Indian Tropical Fruits and Their Bioactive Compounds Against Human Diseases

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