Integrated chemiluminescence-based lab-on-chip for detection of life markers in extraterrestrial environments

Nascetti, A.; Mirasoli, Mara; Marchegiani, Elisa; Zangheri, Martina; Costantini, Francesca; Porchetta, Alessandro; Iannascoli, Lorenzo; Caputo, D.; Cesare, G. de; Pirrotta, Simone; Roda, Aldo

doi:10.1016/j.bios.2018.08.056

Cited by 33 publications

(21 citation statements)

References 30 publications

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“…Among the different reported technologies, amorphous silicon thin-film photodiodes [ 87 , 88 ], organic photodiodes [ 89 , 90 ], carbon nanotubes coated with photovoltaic polymers [ 91 ] and metal–semiconductor–metal photodetectors [ 92 ] have gained great interest. By optimizing chip design, sensor architecture and readout electronics, photon collection efficiency can be increased to achieve analytical performances comparable with CCDs [ 93 , 94 ].…”

Section: Light Detection Technologies Integrated With CL Paper-based Immunoassay Devicesmentioning

confidence: 99%

Paper-Based Immunosensors with Bio-Chemiluminescence Detection

Calabretta

Zangheri

Calabria

et al. 2021

Sensors

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Since the introduction of paper-based analytical devices as potential diagnostic platforms a few decades ago, huge efforts have been made in this field to develop systems suitable for meeting the requirements for the point-of-care (POC) approach. Considerable progress has been achieved in the adaptation of existing analysis methods to a paper-based format, especially considering the chemiluminescent (CL)-immunoassays-based techniques. The implementation of biospecific assays with CL detection and paper-based technology represents an ideal solution for the development of portable analytical devices for on-site applications, since the peculiarities of these features create a unique combination for fitting the POC purposes. Despite this, the scientific production is not paralleled by the diffusion of such devices into everyday life. This review aims to highlight the open issues that are responsible for this discrepancy and to find the aspects that require a focused and targeted research to make these methods really applicable in routine analysis.

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Section: Light Detection Technologies Integrated With CL Paper-based Immunoassay Devicesmentioning

confidence: 99%

Paper-Based Immunosensors with Bio-Chemiluminescence Detection

Calabretta

Zangheri

Calabria

et al. 2021

Sensors

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“…ATP concentration is therefore directly correlated with the amount of microorganisms present in a sample and highly important in several fields such as food contaminants detection, environmental monitoring, and sterility assurance for air and surfaces. [ 101–103 ]…”

Section: Cell‐free Bioluminescence Biosensorsmentioning

confidence: 99%

Bioluminescence goes portable: recent advances in whole‐cell and cell‐free bioluminescence biosensors

et al. 2020

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Recent advancements in synthetic biology, organic chemistry, and computational models have allowed the application of bioluminescence in several fields, ranging from well established methods for detecting microbial contamination to in vivo imaging to track cancer and stem cells, from cell‐based assays to optogenetics. Moreover, thanks to recent technological progress in miniaturized and sensitive light detectors, such as photodiodes and imaging sensors, it is possible to implement laboratory‐based assays, such as cell‐based and enzymatic assays, into portable analytical devices for point‐of‐care and on‐site applications. This review highlights some recent advances in the development of whole‐cell and cell‐free bioluminescence biosensors with a glance on current challenges and different strategies that have been used to turn bioassays into biosensors with the required analytical performance. Critical issues and unsolved technical problems are also highlighted, to give the reader a taste of this fascinating and challenging field.

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“…The on-chip spectrum detection system plays a vital role in the spectrum instrument, widely used in chemical and biological analysis, environment monitoring, hyperspectral imaging and other fields [1][2][3][4]. Conventional spectrometers are usually bulky and expensive.…”

Section: Introductionmentioning

confidence: 99%

Dual Tunable MZIs Stationary-Wave Integrated Fourier Transform Spectrum Detection

Chen

Huang

Wang

et al. 2021

Sensors

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In order to resolve spectral alias due to under sampling in traditional stationary-wave integrated Fourier transform (SWIFT) spectrometers, an all-on-chip waveguide based on dual tunable Mach-Zehnder interferometer (MZI) stationary-wave integrated Fourier transform technology (DTM-SWIFT) is proposed. Several gold nanowires are asymmetrically positioned at two sides of zero optical path difference and scatter the interference fringes information, which can avoid aliasing of spectral signals and help to gain high spectral resolution. A systematic theoretical analysis is carried on in detail, including the optical distribution characteristics based on multi-beam interference, stationary-wave theorem and signal reconstruction method based on the FT technology. The results show that the method can complete a resolution of 6 nm for Gauss spectrum reconstruction using only 6 gold nanowires, and a resolution of 5 cm−1 for Raman spectrum reconstruction using 25 gold nanowires.

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Integrated chemiluminescence-based lab-on-chip for detection of life markers in extraterrestrial environments

Cited by 33 publications

References 30 publications

Paper-Based Immunosensors with Bio-Chemiluminescence Detection

Paper-Based Immunosensors with Bio-Chemiluminescence Detection

Bioluminescence goes portable: recent advances in whole‐cell and cell‐free bioluminescence biosensors

Dual Tunable MZIs Stationary-Wave Integrated Fourier Transform Spectrum Detection

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