Integrated Analysis of lncRNAs and mRNAs Identifies a Potential Driver lncRNA <i>FENDRR</i> in Lung Cancer in Xuanwei, China

Duan, Yong; Li, Wen‐Xing; Wang, Yan; Zhao, Ying; Shen, Jie; Deng, Chunhua; Li, Qing; Chen, Ran; Liu, Xiao; Zhang, Yanliang

doi:10.1080/01635581.2020.1779323

Cited by 5 publications

(2 citation statements)

References 43 publications

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“…These findings suggested that air pollution-related genes might be critical in Xuanwei lung cancer progression. Numerous studies were done to elucidate the multiple mechanisms of Xuanwei and Gejiu lung cancer; however, there were currently no effective treatments for those local lung cancer patients, and the precise molecular mechanism involved remained largely unclear (9,13,49,(51)(52)(53)(54). Previous findings confirmed that microRNAs play critical roles in the development of Xuanwei and Gejiu lung cancer and might be diagnostic biomarkers (9,13,55).…”

Section: Discussionmentioning

confidence: 95%

The Association of microRNA-34a With High Incidence and Metastasis of Lung Cancer in Gejiu and Xuanwei Yunnan

et al. 2021

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The incidence and associated mortality of lung cancer in tin miners in Gejiu County and farmers in Xuanwei Country, Yunnan Province have been very high in the world. Current published literatures on the molecular mechanisms of lung cancer initiation and progression in Gejiu and Xuanwei County are still controversial. Studies confirmed that microRNA-34a (miR-34a) functioned as a vital tumor suppressor in tumorigenesis and progression. However, the role and precise mechanisms of miR-34a and its regulatory gene network in initiation and progression of lung cancer in Gejiu and Xuanwei County, Yunnan Province, have not been elucidated. In the current study, we first found that miR-34a was downregulated in Gejiu lung squamous carcinoma YTMLC-90, Xuanwei lung adenocarcinoma XWLC-05, and other non-small cell lung carcinoma (NSCLC) cell lines, and miR-34a overexpression inhibited cell proliferation, migration and invasion, as well as induced cell apoptosis in YTMLC-90 and XWLC-05 cells. Our findings revealed that miR-34a is critical and cannot be considered as the area-specific non-coding RNA in initiation and progression of lung cancer in Gejiu and Xuanwei County. Next we revealed that miR-34a overexpression suppressed lung cancer growth and metastasis partially via increasing PTEN but reducing CDK6 expression that might lead to subsequent inactivation of PI3K/AKT pathway. Furthermore, our findings demonstrated that YY1 functioned as a tumor suppressor gene in initiation and progression of lung cancer in Gejiu and Xuanwei County. In conclusion, our findings in the study confirmed that miR-34a overexpression could simultaneously suppress tumor growth and metastasis and play a vital role in tumorigenesis and progression of NSCLC via increasing PTEN and YY1 expression, but decreasing CDK6. Most interestingly, our findings also raised doubts about the current ideas about these area-specific diseases.

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Section: Discussionmentioning

confidence: 95%

The Association of microRNA-34a With High Incidence and Metastasis of Lung Cancer in Gejiu and Xuanwei Yunnan

et al. 2021

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“…Transcription factor binding site (TFBS) analysis identified NEPC-associated TF motifs that are present within the NEtD lncRNA sequences which indicates the functional role of identified lncRNAs in NEPC pathogenesis [70]. FOXF1 adjacent noncoding developmentary regulatory RNA (FENDRR) is the most deregulated lncRNA in NEPC [71]. FENDRR is reported to interact with PRC2 which is a key player in prostate tumor progression.…”

Section: Role Of Lncrnas In Crpc and Nepc Progressionmentioning

confidence: 99%

Long non-coding RNAs in castration-resistant and neuroendocrine prostate cancer: Potential role and therapeutic impact

Prajapati¹,

Singh²,

Shuaib³

et al. 2020

ann urol oncol

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Prostate cancer is the most commonly diagnosed malignancy and leading cause of cancer-related deaths in men worldwide. The disease is heterogeneous in nature exhibiting various clinical subtypes and genetic/transcriptomic features. Long non-coding RNAs (lncRNAs) are transcripts of more than 200 nucleotides that does not encode any protein and play important role in several biological processes as well as pathologic states. Deregulation of lncRNAs has been associated with human diseases. In prostate cancer, numerous key lncRNAs have been identified as novel players that contribute to the pathophysiology of the disease primarily regulated by androgen and its cognate receptor. The present review attempts to summarize the potential role of lncRNA and their mechanisms of action in prostate cancer with particular focus on lncRNAs regulated by androgen receptor expressed in castration-resistant and neuroendocrine differentiated subtypes. We also emphasize the potential of these lncRNAs for their development as therapeutic targets in prostate cancer.

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FENDRR: A pivotal, cancer-related, long non-coding RNA

Zheng

Zhang

et al. 2021

Biomedicine & Pharmacotherapy

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Integrated Analysis of lncRNAs and mRNAs Identifies a Potential Driver lncRNA FENDRR in Lung Cancer in Xuanwei, China

Cited by 5 publications

References 43 publications

The Association of microRNA-34a With High Incidence and Metastasis of Lung Cancer in Gejiu and Xuanwei Yunnan

The Association of microRNA-34a With High Incidence and Metastasis of Lung Cancer in Gejiu and Xuanwei Yunnan

Long non-coding RNAs in castration-resistant and neuroendocrine prostate cancer: Potential role and therapeutic impact

FENDRR: A pivotal, cancer-related, long non-coding RNA

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