Measuring the flexibility of the red chilli supply chain is very necessary to determine how flexible the supply chain is to changes and fluctuation that may be faced by each red chilli supply chain actor in Panjatan District. The purpose of this studyis to describe the structure of supply chain relationships based on the actors and their activities and to analysis the flexibility of red chilli supply chain in Panjatan District, Kulon Progo Regency. Kulon Progo Regency was chosen deliberately as the research location because it has highest level of red chilli production in the Special Region of Yogyakarta. Sampling in this study was carried out in several stages starting from Panjatan District, Garongan Village, and Sub-Village 1 and 3. Garongan village was chosen as the sampling location because in 2019 it had the largest number and member of the auction market among other village. The determination of farmer respondents was carried out by purposive sampling method of 80 people. Respondents other than farmers that is 2 auction market manager, 2 district-level collectors, 1 regency-level wholesaler, and 4 regency-level retailers were determined by the snowball sampling method. The method for measuring flexibility is Performance Measurement System (PMS). The result of this research is showed that the structure of the red chili supply chain relationship in Panjatan District, Kulon Progo Regency consist of 2 chains that is chains 1 formed by 5 actors and chain 2 formed by 4 actors and having activities started from red chili cultivation, sorting, grading, weighing, packaging, pricing, bidding, transportation, shipping update information on price and quantities of red chilies, sales, purchase, receiving payments, and making payments. The result of the supply chain flexibility is showed that chain 2 more flexible than chain 1..