Integral Antioxidative Capacity and Antimicrobial Activity of Pressurized Liquid Extracts from 40 Selected Plant Species

강미애,; 김미보,; 김지훈,; 고영환,; 임상빈,

doi:10.3746/jkfn.2010.39.9.1249

Cited by 16 publications

(5 citation statements)

References 13 publications

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“…Owing to the presence of various bioactive constituents and their stability, many researchers have explored biologically active natural products, including those that have anti-inflammatory properties [ 23 , 24 , 25 ]. In particular, phenylpropanoid compounds isolated from natural products are known to exhibit anti-inflammatory activities [ 21 , 26 ].…”

Section: Discussionmentioning

confidence: 99%

Anti-Inflammatory Activity of 4-((1R,2R)-3-Hydroxy-1-(4-hydroxyphenyl)-1-methoxypropan-2-yl)-2-methoxyphenol Isolated from Juglans mandshurica Maxim. in LPS-Stimulated RAW 264.7 Macrophages and Zebrafish Larvae Model

et al. 2021

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Juglans mandshurica Maxim., a traditional folk medicinal plant, is widely distributed in Korea and China. In our previous study, we isolated a new phenylpropanoid compound, 4-((1R,2R)-3-hydroxy-1-(4-hydroxyphenyl)-1-methoxypropan-2-yl)-2-methoxyphenol (HHMP), from J. mandshurica. In the present study, we evaluated the anti-inflammatory activity of HHMP on lipopolysaccharide (LPS)-stimulated RAW 264.7 cells and zebrafish larvae. HHMP significantly inhibited LPS-induced nitric oxide (NO) and prostaglandin E2 production in a dose-dependent manner. Moreover, HHMP treatment considerably suppressed LPS-induced expression of inducible nitric oxide synthase and cyclooxygenase-2. We also demonstrated the mechanisms of HHMP inhibition of inflammatory responses in LPS-stimulated RAW 264.7 cells via Western blot analysis and immunofluorescence staining. Furthermore, HHMP significantly inhibited NO production in LPS-stimulated zebrafish larvae. Consequently, we established that HHMP significantly inhibited the LPS-induced activation of NF-κB and MAPK and the nuclear translocation of p65 in RAW 264.7 cells. Taken together, our findings demonstrate the effect of HHMP on LPS-induced inflammatory responses in vitro and in vivo, suggesting its potential to be used as a natural anti-inflammatory agent.

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Section: Discussionmentioning

confidence: 99%

Anti-Inflammatory Activity of 4-((1R,2R)-3-Hydroxy-1-(4-hydroxyphenyl)-1-methoxypropan-2-yl)-2-methoxyphenol Isolated from Juglans mandshurica Maxim. in LPS-Stimulated RAW 264.7 Macrophages and Zebrafish Larvae Model

et al. 2021

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“…Sera samples of rainbow trout intraperitoneally administered safflower ( Carthamus tinctorius ) ethanolic extract (100 mg/kg body weight) significantly increased anti- S. iniae activity compared to control fish [ 197 ], but no anti- S. iniae activity was seen in the sera of fish treated with a higher dosage (200 mg/kg body weight). Among forty natural Korean plants assessed by Kang et al [ 198 ], only the extractions of nine inhibited the growth of S. iniae and S. parauberis strains, with the strongest inhibition with extracts of Jipsinnamul ( Agrimonia pilosa ), Dokhwal ( Aralia cordat ), N, Nadosongipul ( Phtheirospermum japonicum ), and Sumbadi ( Dystaenia takesimana ) providing the greatest anti- S. parauberis activity. Ethanolic extract of Korean blackberry ( Rubus coreanus ) inhibited the growth of S. iniae and S. parauberis at various concentrations (12.5–100 g/mL), with the extent of inhibition being dose-dependent [ 199 ].…”

Section: Phytotherapymentioning

confidence: 99%

Streptococcosis a Re-Emerging Disease in Aquaculture: Significance and Phytotherapy

Soltani

Leitão

Shafiei

et al. 2022

Animals

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Streptococcosis, particularly that caused by S. iniae and S. agalactiae, is a major re-emerging bacterial disease seriously affecting the global sustainability of aquaculture development. Despite a wide spread of the disease in aquaculture, few studies have been directed at assessing the in vitro antagonistic activity and in vivo efficacy of medicinal herbs and other plants against streptococcal agents. Most in vitro studies of plant extractives against S. iniae and S. agalactiae have found antibacterial activity, but essential oils, especially those containing eugenol, carvacrol or thymol, are more effective. Although essential oils have shown better anti-streptococcal activity in in vitro assays, in vivo bioassays require more attention. The extracts examined under in vivo conditions show moderate efficacy, increasing the survival rate of infected fish, probably through the enhancement of immunity before challenge bioassays. The available data, however, lack dosage optimization, toxicity and bioavailability assays of a specific plant or its bioactive compound in fish organs; hence, it is difficult to judge the validation of clinical efficacy for the prevention or treatment of fish streptococcosis. Despite the known bioactive compounds of many tested plants, few data are available on their mode of action towards streptococcal agents. This review addresses the efficacy of medicinal plants to fish streptococcosis and discusses the current gaps.

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“…disk diffusion method Table 2 , n-hexane ethyl acetate (Choi et al, 2005;Jun et al, 2013). S. iniae , ethanol S. iniae MIC 75.8 µg/mL , MIC 1,000 µg/mL, 3,000 µg/mL (Mok et al, 2001;Kang et al, 2010).…”

Section: 희렴 Methanol 추출물의 분획 및 항균활성mentioning

confidence: 99%

Antibacterial Effect of Siegesbeckia pubescens Extract against Fish Pathogenic Streptococcus iniae

Choi¹,

Cho²,

Lee³

et al. 2016

Korean Journal of Fisheries and Aquatic Sciences

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Antibacterial activity of 80% methanol extract from 13 commercial herb medicines was measured against fish pathogens Streptococcus iniae, causing several diseases in various kind of fish. Siegesbeckia pubescens showed the strongest antibacterial activity against S. iniae. Methanol extract of S. pubescens was further extracted using several organic solvents having different polarity. Extract from n-hexane and ethyl acetate fraction showed strong activity. Minimal inhibitory concentration, MIC of S. pubescens extract was measured and resulted showing 8 µg/mL with n-hexane fraction and 32 µg/mL with ethyl acetate fraction against S. iniae. The growth of S. iniae was fully inhibited by adding 50 µg/mL (final concentration) of n-hexane or ethyl acetate fraction in the liquid media. It is needed that, from these results, purification and isolation of responsible active compound(s) of these activities and further study on the synergy effect using combination with commercial antibiotics against fish pathogenic bacteria.

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Integral Antioxidative Capacity and Antimicrobial Activity of Pressurized Liquid Extracts from 40 Selected Plant Species

Cited by 16 publications

References 13 publications

Anti-Inflammatory Activity of 4-((1R,2R)-3-Hydroxy-1-(4-hydroxyphenyl)-1-methoxypropan-2-yl)-2-methoxyphenol Isolated from Juglans mandshurica Maxim. in LPS-Stimulated RAW 264.7 Macrophages and Zebrafish Larvae Model

Anti-Inflammatory Activity of 4-((1R,2R)-3-Hydroxy-1-(4-hydroxyphenyl)-1-methoxypropan-2-yl)-2-methoxyphenol Isolated from Juglans mandshurica Maxim. in LPS-Stimulated RAW 264.7 Macrophages and Zebrafish Larvae Model

Streptococcosis a Re-Emerging Disease in Aquaculture: Significance and Phytotherapy

Antibacterial Effect of Siegesbeckia pubescens Extract against Fish Pathogenic Streptococcus iniae

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