Intake of ω-3 polyunsaturated fatty acids in patients with rheumatoid arthritis: A systematic review and meta-analysis

Gioxari, Aristea; Kaliora, Andriana C.; Marantidou, Foteini; Panagiotakos, Demosthenes P.

doi:10.1016/j.nut.2017.06.023

Cited by 148 publications

(135 citation statements)

References 72 publications

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“…A more recent meta-analyses evaluated the pain-reducing effect of n-3 fatty acids on patients with rheumatoid inflammatory joint pain or joint pain secondary to inflammation. In these meta-analyses, a reduction in joint pain minutes, intensity, number of painful joints, non-steroid anti-inflammatory drugs (NSAID) use and morning stiffness was found, whereas only one meta-analysis found a reduction in leukotriene B4 [148][149][150]. The strongest effect of n-3 fatty acids was seen with a non-olive oil intake of > 3 g/day [148,149].…”

Section: Omega-3 Fatty Acidsmentioning

confidence: 96%

“…In these meta-analyses, a reduction in joint pain minutes, intensity, number of painful joints, non-steroid anti-inflammatory drugs (NSAID) use and morning stiffness was found, whereas only one meta-analysis found a reduction in leukotriene B4 [148][149][150]. The strongest effect of n-3 fatty acids was seen with a non-olive oil intake of > 3 g/day [148,149]. Accordingly, in the study of Lyte et al, healthy individuals following a saturated fatty acid meal had increased endotoxemia and inflammatory parameters, which decreased after a meal rich in n-3 PUFA, but not after a meal rich in n-6 PUFA [151].…”

Section: Omega-3 Fatty Acidsmentioning

confidence: 96%

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Human Postprandial Nutrient Metabolism and Low-Grade Inflammation: A Narrative Review

et al. 2019

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The importance of the postprandial state has been acknowledged, since hyperglycemia and hyperlipidemia are linked with several chronic systemic low-grade inflammation conditions. Humans spend more than 16 h per day in the postprandial state and the postprandial state is acknowledged as a complex interplay between nutrients, hormones and diet-derived metabolites. The purpose of this review is to provide insight into the physiology of the postprandial inflammatory response, the role of different nutrients, the pro-inflammatory effects of metabolic endotoxemia and the anti-inflammatory effects of bile acids. Moreover, we discuss nutritional strategies that may be linked to the described pathways to modulate the inflammatory component of the postprandial response.

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Section: Omega-3 Fatty Acidsmentioning

confidence: 96%

Section: Omega-3 Fatty Acidsmentioning

confidence: 96%

Human Postprandial Nutrient Metabolism and Low-Grade Inflammation: A Narrative Review

et al. 2019

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“…The role of nutrition and diet has been and continues to be extensively studied. The increased dietary intake of omega‐3 polyunsaturated fatty acids has been reported to improve RA disease activity markers in RA patients . Low‐level sun exposure or low‐vitamin D intake has been associated with an elevated risk of RA development .…”

Section: Environmental Factors That Contribute To Ra Pathogenesismentioning

confidence: 99%

“…The increased dietary intake of omega-3 polyunsaturated fatty acids has been reported to improve RA disease activity markers in RA patients. 113 Low-level sun exposure or low-vitamin D intake has been associated with an elevated risk of RA development. 114 Vitamin D contributes to suppression of autoimmunity through the regulation of T-cells and modulating macrophage responses by preventing release of inflammatory cytokines and chemokines from macrophages and also by decreasing the antigenpresenting activity of lymphocytes and macrophages.…”

Section: Genetic Factors That Contribute To Ra Pathogenesismentioning

confidence: 99%

The genetic pathogenesis, diagnosis and therapeutic insight of rheumatoid arthritis

Zamanpoor

2019

Clinical Genetics

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Rheumatoid arthritis (RA) is a systemic autoimmune disease that causes chronic inflammation of the joints. RA is a heterogeneous disorder caused by an abnormal autoimmune response triggered by the complex interactions of genetic and environmental factors that contribute to RA etiology. However, its underlying pathogenic mechanisms are yet to be fully understood. In this review, I provide an overview of the pathogenesis, diagnosis and therapeutic insight in the clinical management of RA in light of the recent updates to classification criteria and recent discoveries of genetic loci associated with susceptibility for RA.

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“…Clinically, n-3 PUFA supplementation has demonstrated antiinflammatory effects in several arthritic conditions. Multiple randomized controlled trials, systematic reviews, and meta-analyses have noted reduced disease activity with n-3 PUFA consumption in patients with rheumatoid arthritis and psoriatic arthritis (13)(14)(15)(16)(17)(18)(19)(20). Fewer studies have explored the impact of n-3 PUFA consumption on gout, however.…”

Section: Introductionmentioning

confidence: 99%

Effect of Dietary and Supplemental Omega‐3 Polyunsaturated Fatty Acids on Risk of Recurrent Gout Flares

Zhang

Terkeltaub

et al. 2019

Arthritis & Rheumatology

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Objective To determine the relationship between omega‐3 polyunsaturated fatty acid (n‐3 PUFA) consumption (dietary or supplemental) and risk of gout flares. Methods We used data from the Boston University Online Gout Study, an internet‐based case‐crossover study conducted from February 2003 to January 2012. At the times of gout flares (hazard period) and during gout flare–free periods (control periods), participants completed questionnaires regarding exposures, including supplements and diet, during the preceding 48 hours. We examined the relationship of self‐reported n‐3 PUFA–rich supplements and fish intake with the risk of recurrent gout flares using conditional logistic regression, adjusting for total purine intake, diuretic use, and other urate‐lowering or flare prophylactic medications (allopurinol, nonsteroidal antiinflammatory drugs, or colchicine). Results Of the 724 participants, 85% met the 1977 American College of Rheumatology preliminary criteria for the classification of the acute arthritis of primary gout. Twenty‐two percent of the participants reported some form of n‐3 PUFA consumption (supplements, 4.6%; dietary fatty fish, 19%) in the 48 hours preceding a gout flare or flare‐free period. The adjusted odds ratios were 1.01 (95% confidence interval [95% CI] 0.63–1.60; P = 0.98) for all 3 supplements combined and 0.74 (95% CI 0.54–0.99; P = 0.04) for consumption of ≥2 n‐3 PUFA–rich fish servings. Conclusion Dietary n‐3 PUFA–rich fish consumption, when adjusted for total purine intake, was associated with lower risk of recurrent gout flares, whereas n‐3 PUFA supplementation alone, as taken in a self‐directed manner, was not. Consumption of specific sources and adequate doses of n‐3 PUFA for gout flare prevention warrants further study in an adequately powered clinical trial.

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Intake of ω-3 polyunsaturated fatty acids in patients with rheumatoid arthritis: A systematic review and meta-analysis

Cited by 148 publications

References 72 publications

Human Postprandial Nutrient Metabolism and Low-Grade Inflammation: A Narrative Review

Human Postprandial Nutrient Metabolism and Low-Grade Inflammation: A Narrative Review

The genetic pathogenesis, diagnosis and therapeutic insight of rheumatoid arthritis

Effect of Dietary and Supplemental Omega‐3 Polyunsaturated Fatty Acids on Risk of Recurrent Gout Flares

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