“…Of ten case-control studies, seven (Graham et al, 1991;Lee et al, 1991;London et al, 1992;Holmberg et al, 1994;Yuan et al, 1995;Freudenheim et al, 1996;Negri et al, 1996) suggest an inverse association with vitamin E intake and three (Toniolo et al, 1989;Gerber et al, 1990;Richardson et al, 1991) report null or positive associations; the results are statistically significant in four (Graham et al, 1991;London et al, 1992;Freudenheim et al, 1996;Negri et al, 1996) of the studies reporting inverse associations. The results from cohort studies are decidedly weaker: of five studies (Graham et al, 1992;Hunter et al, 1993;Rohan et al, 1993;Kushi et al, 1996;Verhoeven et al, 1997), only one (Graham et al, 1992) reports a relative risk of less than 0.90, and this was not statistically significant.…”