Intake of Dietary Phytoestrogens Is Low in Postmenopausal Women in the United States: The Framingham Study

Kleijn, Miriam J.J. de; Schouw, Yvonne T. van der; Wilson, Peter W.F.; Adlercreutz, Herman; Mazur, Witold; Grobbee, T. Diederick E.; Jacques, Paul F.

doi:10.1093/jn/131.6.1826

Cited by 278 publications

(217 citation statements)

References 35 publications

Supporting

Mentioning

188

Contrasting

Unclassified

Order By: Relevance

“…Previously calculated adult intake in countries such as Canada (0.85 mg/day), 24 the United States (0.64 mg/day) 25 and the Netherlands (1.24 mg/day), 23 are within the ranges found in the present study. A similar figure was obtained for adults in Spain (0.76 mg/day) using household consumption data.…”

Section: Discussionsupporting

confidence: 85%

Determinants of dietary lignan intake in a representative sample of young Spaniards: association with lower obesity prevalence among boys but not girls

et al. 2012

View full text Add to dashboard Cite

BACKGROUND/OBJECTIVES: Lignan-rich diets have been associated with favorable health effects through improved metabolic profile. In this study, we hypothesized that dietary lignan intake could be also associated with childhood obesity. SUBJECTS/METHODS: We studied prevalent obesity in relation to lignan intake within the enKid study that involved 3438 children, adolescents and young adults (2-24 years old). Participant's dietary records were used to calculate lignan dietary intake using a lignan composition database adapted to the Spanish diet. RESULTS: The mean intake of the dietary lignans was calculated as B1 mg/day, corresponding mainly (37%) to pinoresinol. No gender differences were found, but lignan intake was positively associated with age, physical activity level and dietary fiber intake, and negatively with the intake of polyunsaturated and saturated fatty acids. The main sources of dietary lignans were refined wheat, olive oil and whole-wheat bread. A strong association between dietary lignan intake and prevalent obesity was found only for boys, with odds ratio (highest versus lowest quartile of lignan intake) of 0.34 (95% confidence interval, 0.17-0.70) after adjusting for main confounders, including dietary fiber. CONCLUSIONS: Boys with the highest lignan-rich products including cereals, whole-grain products and olive oil, presented less cases of obesity in this representative sample of Spanish children and adolescents. It is unknown whether this association implies an active role of dietary lignans on obesity development, or is merely an indicator of a healthier lifestyle. INTRODUCTIONChildhood obesity has become a major public health issue, both for its increased prevalence worldwide, and its progression to major cardiovascular events later in life that further increases morbidity and mortality. As a disorder of energy balance, obesity is associated with insulin resistance and dyslipidemia. Different bioactive compounds in the diet are currently acknowledged to have favorable effects in these processes. 1 Lignans are fiberrelated phenolic compounds widely distributed in the diet 2 as part of the dietary fiber complex. 3 Lignans are especially abundant in grains, oilseeds, legumes and cruciferous vegetables. [4][5][6] Six different lignans, that is, pinoresinol, lariciresinol, syringaresinol, medioresinol, matairesinol and secoisolariciresinol can be found at relevant concentrations in the human diet. 7 These dietary lignans are absorbed, and to a certain extent (17%) excreted, 8 although the major fraction undergoes an extensive metabolism by the gut microflora that results in the formation of the so-called enterolignans, 9 attending to their colonic origin. These metabolites have been inversely associated with lower weight in women, 10 and further with improved cardiovascular risk factors, and lower risks of acute cardiovascular events. [11][12][13][14][15] There is no information on the intake of lignans in children and adolescents. The aim of this study was to determine the lignan intake and it...

show abstract

Section: Discussionsupporting

confidence: 85%

Determinants of dietary lignan intake in a representative sample of young Spaniards: association with lower obesity prevalence among boys but not girls

et al. 2012

View full text Add to dashboard Cite

show abstract

“…Therefore, the true intake of phytoestrogens and lycopene in our population may be underestimated. Overall, intake of phytoestrogens and lycopene in our study is relatively low, but comparable to that observed in many other Western populations [44,[58][59][60]. Within this low range, limited variation in phytoestrogens and related foods, and lycopene and tomato intake might explain why we did not observe an association with IGF-I and IGFBP-3.…”

Section: Discussionsupporting

confidence: 84%

“…To calculate lycopene intake, an adapted version of the 2001 computerized Dutch food composition table was used. Phytoestrogen intake was calculated using published laboratory analysis data for the phytoestrogen contents of relevant food items [44,45]. Total phytoestrogens is calculated as the sum of total isoflavones (daidzein, genistein, formononetin, biochanin A) and plant lignans (matairesinol, secoisolariciresinol).…”

Section: Data Collectionmentioning

confidence: 99%

Dietary Determinants of Circulating Insulin-like Growth Factor (IGF)-I and IGF Binding Proteins 1, -2 and -3 in Women in the Netherlands

Vrieling

Voskuil

Mesquita

et al. 2004

Cancer Causes Control

View full text Add to dashboard Cite

Objective: Epidemiological studies suggest that individuals with elevated plasma concentrations of insulin-like growth factor (IGF-I) are at increased risk of developing cancer. We assessed whether dietary intake of total energy, protein, alcohol, phytoestrogens and related foods, and tomatoes and lycopene was associated with plasma levels of IGF-I and IGF binding proteins (IGFBPs) in Dutch women. Methods: A cross-sectional study was conducted in 224 premenopausal and 162 postmenopausal women, aged 49-69, participating in the Prospect-EPIC study in the Netherlands. Diet was assessed using a food frequency questionnaire. Results: In postmenopausal women, higher alcohol intake was associated with lower plasma IGFBP-1 concentrations (alcohol 1.4 to 20 g/day: 20% decrease in IGFBP-1; p ¼ 0.04), and higher intake of plant lignans was associated with higher IGFBP-1 concentrations (plant lignans 0 to 1 mg/day: 59% increase in IGFBP-1; p ¼ 0.02). Higher soy intake was associated with higher plasma IGFBP-2 concentrations in premenopausal women (soy 0 to 2.5 g/day: 3% increase in IGFBP-2; p ¼ 0.04). No independent associations of dietary factors with IGF-I or IGFBP-3 concentrations were observed. However, in premenopausal women alcohol intake was inversely associated with IGF-I and positively associated with IGFBP-3 after mutual adjustment. Conclusions: In this study population, with limited variation in dietary intake, total energy, protein, phytoestrogens and lycopene were not associated with IGF-I and IGFBP-3. Alcohol was inversely, and some measures of phytoestrogen intake were positively associated with plasma IGFBP-1 or -2 concentrations. The roles of IGFBP-1 and -2 in relation to IGF-I bioactivity and cancer deserve further investigation.

show abstract

“…We also estimated daidzein and genistein intake based on responses to the DAF using a previously described method (19). In this method, isoflavone values were assigned to each food item in the DAF using values identified in the literature and unpublished data from experts in the field.…”

Section: Assessment Of Isoflavone Intakementioning

confidence: 99%

Food Frequency Questionnaires and Overnight Urines Are Valid Indicators of Daidzein and Genistein Intake in U.S. Women Relative to Multiple 24-h Urine Samples

Tseng

Olufade

Kurzer

et al. 2008

Nutrition and Cancer

Self Cite

View full text Add to dashboard Cite

Data regarding convenient, valid methods for measuring U.S. isoflavone intake are limited. We evaluated a soy food questionnaire (SFQ), the Willett food frequency questionnaire (FFQ), and overnight urine samples relative to excretion in 24-h urine samples. We also described intake among women in a high-risk program for breast or ovarian cancer. Between April 2002 and June 2003, 451 women aged 30 to 50 yr with a family history of breast or ovarian cancer completed the SFQ and FFQ. Of them, 27 provided four 24-h and overnight urine specimens. In these women, 24-h sample measures were correlated with SFQ estimates of daidzein (Spearman r = .48) and genistein (r = .54) intake, moderately correlated with the Willett FFQ (daidzein r = .38, genistein r = .33), and strongly correlated with overnight urine excretion (daidzein r = .84, genistein r = 0.93). Among all 451 SFQ respondents, mean (median) daidzein and genistein intakes were 2.8 (0.24) and 3.9 (0.30) mg/day. Primary sources of both were soymilk, soy nuts, and tofu. We conclude that targeted soy food questionnaires, comprehensive FFQs, and multiple overnight urines are all reasonable options for assessing isoflavone intake in epidemiologic studies.

show abstract

Intake of Dietary Phytoestrogens Is Low in Postmenopausal Women in the United States: The Framingham Study

Cited by 278 publications

References 35 publications

Determinants of dietary lignan intake in a representative sample of young Spaniards: association with lower obesity prevalence among boys but not girls

Determinants of dietary lignan intake in a representative sample of young Spaniards: association with lower obesity prevalence among boys but not girls

Dietary Determinants of Circulating Insulin-like Growth Factor (IGF)-I and IGF Binding Proteins 1, -2 and -3 in Women in the Netherlands

Food Frequency Questionnaires and Overnight Urines Are Valid Indicators of Daidzein and Genistein Intake in U.S. Women Relative to Multiple 24-h Urine Samples

Contact Info

Product

Resources

About