Food Frequency Questionnaires and Overnight Urines Are Valid Indicators of Daidzein and Genistein Intake in U.S. Women Relative to Multiple 24-h Urine Samples

Tseng, Marilyn; Olufade, Temitope; Kurzer, Mindy S.; Wähälä, Kristiina; Fang, Carolyn Y.; Schouw, Yvonne T. van der; Daly, Mary B.

doi:10.1080/01635580801993751

Cited by 14 publications

(14 citation statements)

References 25 publications

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“…Plasma and urine concentrations were also consistent with those previously reported in individuals consuming a Western diet (7, 8). However, we failed to show a correlation between the soy isoflavones from the Soy FFQ and plasma and urine concentrations for genistein and daidzein.…”

Section: Discussionsupporting

confidence: 89%

“…The majority of subjects enrolled in this study were male, (87%) and older, with a median age of 71 (range 46-97), consistent with individuals at risk for bladder cancer. Another potential explanation for the difference is that the Soy FFQ was validated for plasma concentrations and we also evaluated urine, although other Soy FFQs have been validated for urine concentrations (7, 8). …”

Section: Discussionmentioning

confidence: 99%

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Soy food frequency questionnaire does not correlate with baseline isoflavone levels in patients with bladder cancer

Kolesar

Pomplun

Havighurst

et al. 2014

J Oncol Pharm Pract

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Background The isoflavone genistein, a natural soy product with receptor tyrosine kinase inhibiting activity, as well as phytoestrogenic and other potential anticarcinogenic effects is being studied as an anticancer agent. Since isoflavones are commonly consumed in food products containing soy proteins, a method to control for baseline isoflavone consumption is needed. Methods HPLC was used to evaluate baseline plasma and urine concentrations of isoflavone in fifty-four participants with bladder cancer enrolled on a phase II chemoprevention study of G-2535. The soy food frequency questionnaire (Soy FFQ) was used to assess participant's baseline soy intake. The association between baseline isoflavone concentrations and intakes for genistein and daidzein was assessed by the Spearman's rank correlation coefficient. Results The majority of participants had no detectable genistein or daidzein in plasma at baseline. The median and range of values were 0 (0-1,480) nmol/L for genistein, and 0 (0-1,260) nmol/L for daidzein. In urine, the median and range of values were 91.0 (0-9,030) nmol/L for genistein and 623 (0-100,000) nmol/L for daidzein. The median and range of weekly estimated genistein intake was 0 (0-236) mg/wk; the median and range of weekly estimated daidzein intake was 0 (0-114) mg/wk. There was no relationship to soy intake as measured by the FFQ and baseline isoflavone levels in plasma or urine and the Spearman's rank correlation coefficients were not significant. Conclusion The Soy FFQ did not correlate with plasma or urine concentrations of either isoflavone. Impact Alternative methods for controlling for soy consumption, including measuring plasma and urine concentrations, in isoflavone chemoprevention trials should be considered.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Soy food frequency questionnaire does not correlate with baseline isoflavone levels in patients with bladder cancer

Kolesar

Pomplun

Havighurst

et al. 2014

J Oncol Pharm Pract

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“…In another US population study, positive correlations were demonstrated between self-reported soy intake and excretion of urinary isoflavones ( r = 0.52, p < 0.001 for dietary recall and r = 0.29, p < 0.01 for FFQ) [ 42 ]. In a US study ( n = 451 women) [ 43 ], 24-h urine sample measures were shown to be strongly correlated with overnight urine excretion for daidzein ( r = 0.84) and genistein ( r = 0.93). The 24-h urine sample measures were also correlated with soy food questionnaire (SFQ) estimates of daidzein ( r = 0.48) and genistein ( r = 0.54) intake [ 43 ].…”

Section: Resultsmentioning

confidence: 99%

Biomarkers of legume intake in human intervention and observational studies: a systematic review

et al. 2018

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There is a growing interest in assessing dietary intake more accurately across different population groups, and biomarkers have emerged as a complementary tool to replace traditional dietary assessment methods. The purpose of this study was to conduct a systematic review of the literature available and evaluate the applicability and validity of biomarkers of legume intake reported across various observational and intervention studies. A systematic search in PubMed, Scopus, and ISI Web of Knowledge identified 44 studies which met the inclusion criteria for the review. Results from observational studies focused on soy or soy-based foods and demonstrated positive correlations between soy intake and urinary, plasma or serum isoflavonoid levels in different population groups. Similarly, intervention studies demonstrated increased genistein and daidzein levels in urine and plasma following soy intake. Both genistein and daidzein exhibited dose-response relationships. Other isoflavonoid levels such as O-desmethylangolensin (O-DMA) and equol were also reported to increase following soy consumption. Using a developed scoring system, genistein and daidzein can be considered as promising candidate markers for soy consumption. Furthermore, genistein and daidzein also served as good estimates of soy intake as evidenced from long-term exposure studies marking their status as validated biomarkers. On the contrary, only few studies indicated proposed biomarkers for pulses intake, with pipecolic acid and S-methylcysteine reported as markers reflecting dry bean consumption, unsaturated aliphatic, hydroxyl-dicarboxylic acid related to green beans intake and trigonelline reported as marker of peas consumption. However, data regarding criteria such as specificity, dose-response and time-response relationship, reliability, and feasibility to evaluate the validity of these markers is lacking. In conclusion, despite many studies suggesting proposed biomarkers for soy, there is a lack of information on markers of other different subtypes of legumes. Further discovery and validation studies are needed in order to identify reliable biomarkers of legume intake.Electronic supplementary materialThe online version of this article (10.1186/s12263-018-0614-6) contains supplementary material, which is available to authorized users.

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“…Biomarkers of intakes were not used in the studies reviewed. Although there have been several recent studies of flavonoid biomarkers 134–139 and several studies validating isoflavone intakes, 140–153 very few studies 154–156 validating other flavonoids have been done that examined blood or urine samples for biomarkers 157,158 . Thus, the errors in flavonoid intake assessment may have been considerable.…”

Section: Discussionmentioning

confidence: 99%

Associations between flavonoids and cardiovascular disease incidence or mortality in European and US populations

Peterson¹,

Dwyer²,

Jacques³

et al. 2012

Nutrition Reviews

185

122

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Twenty publications from twelve prospective cohorts evaluated associations between flavonoid intakes and incidence or mortality from cardiovascular disease among adults in Europe and the United States (US). The most common outcome was coronary heart disease mortality, and four of eight cohort studies reported significant inverse associations for at least one flavonoid class (multivariate adjusted ptrend <.05). Three of seven cohorts reported that greater flavonoid intake was associated with lower risk of incident stroke. Comparisons were difficult because of variability in the flavonoid classes included, demographic characteristics of the populations, outcomes assessed, and length of follow up. The most common flavonoid classes examined were flavones and flavonols combined (11 studies). Only one study examined all seven flavonoid classes. The flavonol and flavone classes were most strongly associated with lower CHD mortality. Evidence for protection from other flavonoid classes and CVD outcomes was more limited. The hypothesis that flavonoid intakes are associated with lower CVD incidence and mortality requires further study.

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Food Frequency Questionnaires and Overnight Urines Are Valid Indicators of Daidzein and Genistein Intake in U.S. Women Relative to Multiple 24-h Urine Samples

Cited by 14 publications

References 25 publications

Soy food frequency questionnaire does not correlate with baseline isoflavone levels in patients with bladder cancer

Soy food frequency questionnaire does not correlate with baseline isoflavone levels in patients with bladder cancer

Biomarkers of legume intake in human intervention and observational studies: a systematic review

Associations between flavonoids and cardiovascular disease incidence or mortality in European and US populations

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