Intake of 1-Deoxynojirimycin Suppresses Lipid Accumulation through Activation of the β-Oxidation System in Rat Liver

Abstract

It was recently shown that administration of 1-deoxynojirimycin (DNJ) extracted from mulberry suppresses an increase in postprandial blood glucose in humans. These findings are of interest, but other physiological functions of DNJ are unknown. This study examined the effects of oral administration of DNJ (1 mg/kg of body weight/day) or mulberry extracts enriched in DNJ (meDNJ; 100 or 200 mg of extract/kg of body weight/day, equivalent to 0.53 or 1.06 mg of DNJ/kg of body weight/day) in male Sprague-Dawley rats for 4 weeks. DNJ and meDNJ enhanced expression of adiponectin mRNA in white adipose tissue; increased plasma adiponectin levels, enhanced expression of AMPK mRNA, activated the beta-oxidation system, and suppressed lipid accumulation in the liver. Intake of DNJ and meDNJ did not cause hepatic dysfunction and led to a reduction of oxidative stress. These results indicate the efficacy and safety of DNJ and meDNJ.

Studies Targeting α-Glucosidase Inhibition, Antiangiogenic Effects, and Lipid Modification Regulation: Background, Evaluation, and Challenges in the Development of Food Ingredients for Therapeutic Purposes

“…Hence, our research group examined other effects of DNJ in a study of rats, and found that dietary DNJ supplementation enhanced expression of adiponectin mRNA in white adipose tissue, increased plasma adiponectin levels, enhanced expression of AMPK mRNA, activated the -oxidation system, and suppressed lipid accumulation in the liver. 13) Intake of DNJ did not cause hepatic dysfunction, and led to reduced oxidative stress. Thus, DNJ might be therapeutically useful and safe in the treatment of obesity as well as diabetes.…”

Mulberry leaves (Morus alba L.) ameliorate obesity-induced hepatic lipogenesis, fibrosis, and oxidative stress in high-fat diet-fed mice

“…These natural compounds were shown to exert anti-obesity effects by inhibiting differentiation of preadipocytes (Rayalam et al 2008) and stimulating b-oxidation system (Tsuduki et al 2009). Previous studies proved that DNJ-rich MLE has been potentially used to improve lipid profiles in a human study (Doi et al 2000) and to suppress lipid accumulation through activation of the b-oxidation in vivo (Tsuduki et al 2009). In addition, resveratrol has properties to decrease ROS ) and stimulate PPARa involved in fatty acid oxidation (Nakata et al 2012).…”

Influence of mulberry leaf extract on serum adiponectin, visfatin and lipid profile levels in type 2 diabetic rats

“…Since it has been shown to be effective in decreasing lipid accumulation not only via increasing β-oxidation, but also by increasing adiponectin levels and activating AMP-activated protein kinase (AMPK) in isolated rat liver (32). Insulin resistance maybe responsible for dyslipidemia, because insulin has an inhibitory action on HMG-coA reductase, a key enzyme in metabolism of cholesterol rich LDL-cholesterol particle (33).…”