Insulins, leptin and feeding in a population of Peromyscus leucopus (white-footed mouse) with variable fertility

White, Jordan T.; DeSanto, C.L.; Gibbons, Connie; Lardner, Casey K.; Panakos, Andrew; Rais, Salehin; Sharp, Kathy; Sullivan, Shannon D.; Tidhar, Wendy; Wright, L. D.; Berrigan, David; Heideman, Paul D.

doi:10.1016/j.yhbeh.2014.02.006

Cited by 3 publications

(3 citation statements)

References 52 publications

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“…However the precise timing and inter-relationship of seasonal cycles of appetite, fattening and reproductive activity is species specific, perhaps reflecting the trade-offs that have evolved between appetitive behaviors underlying acquisition of calories versus those promoting reproduction (Schneider et al, 2013). Moreover, even within species there may be polymorphisms in the inter-relationships of seasonal cycles of metabolic rate, feeding, activity and fertility [see White et al, 2014 for review].…”

Section: Introductionmentioning

confidence: 99%

On the value of seasonal mammals for identifying mechanisms underlying the control of food intake and body weight

Ebling

2014

Hormones and Behavior

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This article is part of a Special Issue “Energy Balance”.Seasonal cycles of adiposity and body weight reflecting changes in both food intake and energy expenditure are the norm in mammals that have evolved in temperate and polar habitats. Innate circannual rhythmicity and direct responses to the annual change in photoperiod combine to ensure that behavior and energy metabolism are regulated in anticipation of altered energetic demands such as the energetically costly processes of hibernation, migration, and lactation. In the last decade, major progress has been made into identifying the central mechanisms that underlie these profound long-term changes in behavior and physiology. Surprisingly they are distinct from the peptidergic and aminergic systems in the hypothalamus that have been identified in studies of the laboratory mouse and rat and implicated in timing meal intervals and in short-term responses to caloric restriction. Comparative studies across rodents, ungulates and birds reveal that tanycytes embedded in the ependymal layer of the third ventricle play a critical role in seasonal changes because they regulate the local availability of thyroid hormone. Understanding how this altered hormonal environment might regulate neurogenesis and plasticity in the hypothalamus should provide new insight into development of strategies to manage appetite and body weight.

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Section: Introductionmentioning

confidence: 99%

On the value of seasonal mammals for identifying mechanisms underlying the control of food intake and body weight

Ebling

2014

Hormones and Behavior

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“… 89 90 Various pieces of evidence have pointed to a direct role of leptin in the control of male reproduction. 91 92 93 94 In particular, ob/ob male mice (lacking functional leptin) or db/db male mice (lacking functional leptin receptor) are infertile and fail to undergo normal sexual maturation. 95 In human, leptin is expressed in the seminiferous tubules 96 97 and in seminal plasma 98 99 while the leptin receptor is found in the interstitium, primarily in the Leydig cells.…”

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Peroxisome proliferator-activated receptor gamma signaling in human sperm physiology

et al. 2015

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Peroxisome proliferator-activated receptor gamma (PPARγ) is a member of the PPARs, which are transcription factors of the steroid receptor superfamily. PPARγ acts as an important molecule for regulating energy homeostasis, modulates the hypothalamic-pituitary-gonadal (HPG) axis, and is reciprocally regulated by HPG. In the human, PPARγ protein is highly expressed in ejaculated spermatozoa, implying a possible role of PPARγ signaling in regulating sperm energy dissipation. PPARγ protein is also expressed in Sertoli cells and germ cells (spermatocytes). Its activation can be induced during capacitation and the acrosome reaction. This mini-review will focus on how PPARγ signaling may affect fertility and sperm quality and the potential reversibility of these adverse effects.

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“…Both selection lines undergo reproductive suppression under short relative to long photoperiod (Heideman & Pittman, 2009), but only in the responder line does reproductive suppression under short photoperiod commonly result in low levels of spermatozoa: azoospermia or oligospermia (Broussard et al, 2009). These selection lines have been shown to differ heritably in reproductive traits (reproductive organ size, number of immunoreactive GnRH neurons, levels of luteinizing hormone: Avigdor, Sullivan & Heideman, 2005; Heideman et al, 1999; Heideman et al, 2010) as well as some, but not all, nonreproductive traits that may affect fertility (ad libitum food intake, metabolic rate, physical activity, amount of iodomelatonin binding in the brain: Heideman & Pittman, 2009; Heideman et al, 2010; Kaseloo, Crowell & Heideman, 2014; Kaseloo, Crowell, Jones & Heideman, 2012; White et al, 2014). …”

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Genetic variation in male sexual behaviour in a population of white-footed mice in relation to photoperiod

et al. 2015

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In natural populations, genetic variation in seasonal male sexual behaviour could affect behavioural ecology and evolution. In a wild-source population of white-footed mice, Peromyscus leucopus, from Virginia, U.S.A., males experiencing short photoperiod show high levels of genetic variation in reproductive organ mass and neuroendocrine traits related to fertility. We tested whether males from two divergent selection lines, one that strongly suppresses fertility under short photoperiod (responder) and one that weakly suppresses fertility under short photoperiod (nonresponder), also differ in photoperiod-dependent sexual behaviour and responses to female olfactory cues. Under short, but not long, photoperiod, there were significant differences between responder and nonresponder males in sexual behaviour and likelihood of inseminating a female. Males that were severely oligospermic or azoospermic under short photoperiod failed to display sexual behaviour in response to an ovariectomized and hormonally primed receptive female. However, on the day following testing, females were positive for spermatozoa only when paired with a male having a sperm count in the normal range for males under long photoperiod. Males from the nonresponder line showed accelerated reproductive development under short photoperiod in response to urine-soiled bedding from females, but males from the responder line did not. The results indicate genetic variation in sexual behaviour that is expressed under short, but not long, photoperiod, and indicate a potential link between heritable neuroendocrine variation and male sexual behaviour. In winter in a natural population, this heritable behavioural variation could affect fitness, seasonal life history trade-offs and population growth.

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Insulins, leptin and feeding in a population of Peromyscus leucopus (white-footed mouse) with variable fertility

Cited by 3 publications

References 52 publications

On the value of seasonal mammals for identifying mechanisms underlying the control of food intake and body weight

On the value of seasonal mammals for identifying mechanisms underlying the control of food intake and body weight

Peroxisome proliferator-activated receptor gamma signaling in human sperm physiology

Genetic variation in male sexual behaviour in a population of white-footed mice in relation to photoperiod

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