1996
DOI: 10.1006/abbi.1996.0504
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Insulinotropic Action of Methyl Pyruvate: Secretory, Cationic, and Biosynthetic Aspects

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Cited by 22 publications
(10 citation statements)
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“…This notion is supported by data reported by Malaisse et al. [51], who showed that methyl pyruvate causes less lactate production than sodium pyruvate in pancreatic islets, a finding that is consistent with decreased cytoplasmic metabolism and increased mitochondrial metabolism by the ester. Furthermore, Rocheleau et al.…”
Section: Introductionsupporting
confidence: 84%
“…This notion is supported by data reported by Malaisse et al. [51], who showed that methyl pyruvate causes less lactate production than sodium pyruvate in pancreatic islets, a finding that is consistent with decreased cytoplasmic metabolism and increased mitochondrial metabolism by the ester. Furthermore, Rocheleau et al.…”
Section: Introductionsupporting
confidence: 84%
“…However, methyl pyruvate has been reported to stimulate insulin secretion directly through ATPsensitive K ϩ channels and not cause a significant rise in NAD(P)H intensity (34). This metabolite also causes less lactate production, which is consistent with decreased cytoplasmic metabolism and increased mitochondrial metabolism (35). The addition of methyl pyruvate caused larger and sustained NAD(P)H (f) and LipDH (q) responses (Fig.…”
Section: Fig 7 Nad(p)h and Mitochondrial Nadh Responses To Glucosesupporting
confidence: 52%
“…In contrast to exogenous pyruvate, fast methyl pyruvate transport likely increases the availability of pyruvate to PDH. Also, methyl pyruvate has been shown to cause less lactate production than pyruvate (35), consistent with its being less metabolized in the cytoplasm than exogenous pyruvate.…”
Section: Fig 7 Nad(p)h and Mitochondrial Nadh Responses To Glucosementioning
confidence: 89%
“…In other reports, KIC induced slow Ca 2ϩ oscillations (31) and secretion in the absence of substimulatory glucose (14,40), which agrees with our data. In some of these studies, the nonglycogenic substrate (MeP) was applied in a concentration (20 mM) (5) that has been shown to block secretion (30), making it difficult to interpret such data. Some secretagogues, such as glyceraldehyde, have been shown to be toxic and not metabolized via the glycolytic pathway to an extent proposed earlier (27), and fuels such as pyruvate or succinate are not membrane permeable and, as such, would not stimulate metabolism in contrast to their methylated analogs (24).…”
Section: Discussionmentioning
confidence: 99%