Insulin, Unlike Food Intake, Does Not Suppress Ghrelin in Human Subjects

Caixàs, Assumpta

doi:10.1210/jc.87.4.1902

Cited by 102 publications

(58 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our data regarding ghrelin levels during the OGTT are in accordance with previous data showing that insulin is a key regulator of the postprandial ghrelin suppression response [8], although some controversy surrounds this topic [9]. To date, studies (at least in humans) indicate that supraphysiological or prolonged peripheral insulin administration affects the plasma ghrelin concentration [10].…”

Section: Discussionsupporting

confidence: 91%

“…To date, studies (at least in humans) indicate that supraphysiological or prolonged peripheral insulin administration affects the plasma ghrelin concentration [10]. However, physiological short-term peripheral insulin elevation had no effect on ghrelin levels in most of these studies [9,10]. Our data show that during the OGTT the elevations in the plasma insulin level are able to induce insulin signalling in the hypothalamus, as demonstrated by increased IR tyrosine phosphorylation and Akt serine phosphorylation in this tissue.…”

Section: Discussionmentioning

confidence: 52%

See 1 more Smart Citation

Circulating ghrelin concentrations are lowered by intracerebroventricular insulin

et al. 2006

View full text Add to dashboard Cite

Aims/hypothesis Ghrelin is a peptide that is mainly produced by the stomach and stimulates food intake, adiposity and weight gain. Previous studies have documented that plasma levels of ghrelin are reduced by insulin, but the mechanisms that mediate this effect are unclear. Methods To determine whether phosphatidylinositol 3-kinase (PI(3)K) and/or mitogen-activated protein kinase (MAPK) are involved in this insulin action, we tested the intracerebroventricular (i.c.v.) effect of specific inhibitors of PI(3)K (LY294002 and wortmannin) and MAPK (PD98059 and UO126) on the insulin-mediated reduction of ghrelin levels in rats. Results Intracerebroventricular treatment with insulin reduced ghrelin levels. Inhibition of PI(3)K specifically blocked the insulin-induced reduction in ghrelin concentration, whereas inhibition of MAPK had no effect on insulinmediated actions. Moreover, pretreatment with i.c.v. PI(3)K inhibitors blocked the reduction of ghrelin levels after OGTT-induced hyperglycaemia and hyperinsulinaemia. Conclusions/interpretation These data demonstrate that changes in insulin action in the central nervous system regulate circulating ghrelin levels and that PI(3)K is a specific mediator of this action.

show abstract

Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 52%

Circulating ghrelin concentrations are lowered by intracerebroventricular insulin

et al. 2006

View full text Add to dashboard Cite

show abstract

“…Normal weight children had an age-matched BMI below 25 kg/m 2 for adults. Mean age of obese patients was 13.9 years (range 10-16), and of control children 12.3 years (range [10][11][12][13][14][15]. Patients with underlying gastrointestinal disease or endocrine disorders and patients receiving systemic glucocorticoid therapy were excluded from the study.…”

Section: Subjectsmentioning

confidence: 99%

“…12 However, this effect could not be demonstrated in other studies. 13,14 Recently, McLaughlin et al 15 demonstrated that plasma ghrelin concentrations were lower in insulin-resistant obese adults relative to equally obese insulin-sensitive controls.…”

Section: Introductionmentioning

confidence: 99%

Regulation of ghrelin is related to estimated insulin sensitivity in obese children

Krohn

Boczan

Otto³

et al. 2006

Int J Obes

View full text Add to dashboard Cite

Objective: To investigate whether ghrelin concentrations and their changes during weight loss in obese children are associated with parameters of glucose and insulin metabolism. Design: Total plasma ghrelin, insulin and glucose were measured during oral glucose tolerance testing before and after dietinduced weight loss over 6 weeks. Setting: In-patient rehabilitation program in a pediatric hospital. Participants: Twenty-three obese children (age 10-16 years) and 11 normal weight controls (age 10-15 years). Outcome measures: Changes in ghrelin concentrations during weight loss and correlation analysis of changes in ghrelin and changes in parameters of glucose and insulin metabolism. After data collection, subgroup analysis of obese patients with high, medium and low estimated insulin sensitivity whole-body insulin sensitivity index (WBISI) was performed. Results: Weight loss increased the area under the curve (AUC) of ghrelin by 26% (Po0.001). The increase in ghrelin AUC correlated significantly with improved estimated insulin sensitivity (WBISI) (r ¼ 0.69, Po0.001). The independent predicting effect of WBISI was confirmed in multivariate analysis. In children with low WBISI, ghrelin reached the level of control values after weight loss. In children with high WBISI, ghrelin increased markedly above control levels. Conclusions: Changes in ghrelin are independently associated with changes in glucose and insulin metabolism. The increase in plasma ghrelin above control levels was limited to obese children with high WBISI.

show abstract

“…Fasting state and meal ingestion probably have the most significant effect on the variation of ghrelin concentration. Food intake and hyperglycaemia suppress ghrelin secretion [10,11] but it is controversial whether changes in glucose or insulin mediate this effect [10,12]. Several studies have shown ghrelin to be negatively associated with BMI [13][14][15] and insulin [13,15,16].…”

mentioning

confidence: 99%

The negative association between plasma ghrelin and IGF-I is modified by obesity, insulin resistance and type 2 diabetes

et al. 2005

View full text Add to dashboard Cite

Aims/hypothesis: Ghrelin is a natural growth hormone-releasing peptide thought to be involved in the regulation of energy metabolism. The recent studies concerning the association between ghrelin and insulin-like growth factor-I (IGF-I) concentrations have shown either negative correlation or no correlation at all. The aims of this study were to clarify the association between ghrelin and IGF-I concentrations in a large cohort and to characterize whether obesity, insulin resistance and type 2 diabetes affect this association. Methods: We analysed fasting plasma ghrelin and IGF-I concentrations of 1,004 middleaged subjects of the population-based OPERA study. Insulin resistance was estimated using QUICKI. Results: IGF-I concentrations were negatively associated with ghrelin concentrations in the analysis of all subjects before (β= −0.32, p<0.001) and after adjustments for BMI, insulin levels, sex and age (β=−0.40, p<0.001). The association was particularly strong in males and in the higher BMI tertiles. The degree of association varied in relation to the glycaemic status: no insulin resistance: r 2 =6.5% (p<0.001), insulin resistance without type 2 diabetes: r 2 =21.0% (p< 0.001), type 2 diabetes: r 2 =25.4 (p<0.001). IGF-I levels explained larger proportion (r 2 =9.8%) of the variation in ghrelin concentrations compared to fasting insulin concentration (r 2 =3.0%) and BMI (r 2 =1.5%). Conclusions/ interpretation: There is a negative and independent association between ghrelin and IGF-I concentrations in middleaged subjects. The interaction between IGF-I and ghrelin is modified by obesity, IR and type 2 diabetes. Further studies are warranted to elucidate the role of ghrelin in the development of these states.

show abstract

Insulin, Unlike Food Intake, Does Not Suppress Ghrelin in Human Subjects

Abstract: Unlike food intake, the administration of insulin and glucose does not suppress ghrelin levels. These data suggest that the suppressive effect of food intake or oral glucose on serum ghrelin is unlikely mediated by the changes of plasma insulin and glucose observed after the ingestion.

Cited by 102 publications

References 0 publications

Circulating ghrelin concentrations are lowered by intracerebroventricular insulin

Circulating ghrelin concentrations are lowered by intracerebroventricular insulin

Regulation of ghrelin is related to estimated insulin sensitivity in obese children

The negative association between plasma ghrelin and IGF-I is modified by obesity, insulin resistance and type 2 diabetes

Contact Info

Product

Resources

About