Insulin therapy

Lechleitner, Monika; Hoppichler, Friedrich

doi:10.1007/s10354-011-0889-3

Cited by 4 publications

(5 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…According to the World Health Organization (WHO), approximately 422 million people are living with diabetes worldwide [ 2 ]. Despite various antidiabetic drugs being used in the management of diabetes, exogenous insulin remains the gold standard treatment for type 1 diabetes [ 3 ]. Insulin, an anabolic hormone, plays a major role in maintaining glucose homeostasis through various mechanisms including glucose uptake by the skeletal muscle and the adipose tissues, promoting glycogenesis and inhibiting glycogenolysis and gluconeogenesis [ 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

A Dioxidovanadium Complex cis-[VO2 (obz) py] Attenuates Hyperglycemia in Streptozotocin (STZ)-Induced Diabetic Male Sprague-Dawley Rats via Increased GLUT4 and Glycogen Synthase Expression in the Skeletal Muscle

Mbatha

Khathi

Sibiya

et al. 2022

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Vanadium has demonstrated antihyperglycemic effects in diabetes mellitus (DM) but is, however, associated with toxicity. Therefore, new vanadium complexes envisaged to possess heightened therapeutic potency while rendering less toxicity are being explored. Accordingly, the aim of the study was to investigate the effects of a dioxidovanadium (V) complex, cis-[VO2 (obz) py], on selected glucose metabolism markers in streptozotocin (STZ)-induced diabetic rats. STZ-induced diabetic rats were treated orally with cis-[VO2 (obz) py] (10, 20, and 40 mg/kg) twice every 3rd day for 5 weeks. Blood glucose concentrations, body weight, and food and water intake were monitored weekly, for 5 weeks. Rats were then euthanized after which blood, liver, and muscle tissues were collected for biochemical analysis. The administration of dioxidovanadium complex significantly decreased blood glucose concentrations throughout the 5-week period in comparison with the diabetic control (DC). The attenuation of hyperglycemia was accompanied by an increased glycogen concentration in both liver and muscle tissues in the treated groups. Furthermore, a significant increase was observed in the expression of glucose transporter type 4 (GLUT4) in the skeletal muscle tissues and glycogen synthase in the liver tissues. These findings indicate that our vanadium complex cis-[VO2 (obz) py] may exert antihyperglycemic effects through increased glucose uptake, glycogen synthesis, and increased GLUT4 and glycogen synthase expression.

show abstract

Section: Introductionmentioning

confidence: 99%

A Dioxidovanadium Complex cis-[VO2 (obz) py] Attenuates Hyperglycemia in Streptozotocin (STZ)-Induced Diabetic Male Sprague-Dawley Rats via Increased GLUT4 and Glycogen Synthase Expression in the Skeletal Muscle

Mbatha

Khathi

Sibiya

et al. 2022

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

show abstract

“…20,23 Apesar de no presente estudo não se terem verificado diferenças estatisticamente significativas no que refere à existência de outras patologias concomitantes (como doenças cardíacas, oculares, renais e vasculares) e o controlo metabólico da DM1, alguns estudos referem que uma diminuição da HbA 1c em 1% está associada a uma drástica redução da prevalência de complicações macro e microvasculares, o que demonstra a importância da manutenção de um bom controlo metabólico da doença por parte destes doentes. 12,20 No presente trabalho, a inexistência de resultados com significado estatístico poderá relacionar-se com o tamanho reduzido de elementos de cada grupo após estratificação da amostra segundo o controlo metabólico dos doentes. Por outro lado, teria sido importante a averiguação do tempo de doença dos elementos do grupo dos doentes com diabetes mellitus, o que não foi feito.…”

Section: Discussionunclassified

“…1,2,10 A administração diária de insulina é, assim, crucial para regular os níveis de glicose no sangue, assim como para a sobrevivência dos doentes. 2,5,11,12 A grande maioria dos doentes com DM1 segue um regime de múltiplas administrações de insulina ao longo do dia. [11][12][13] A insulinoterapia parece estar associada a um aumento significativo de peso e hipoglicé-mia, pelo que os doentes com diabetes devem ser acompanhados em consultas de nutrição e dietética.…”

Section: Introductionunclassified

Prevalência de Lesões de Cárie de Doentes com Diabetes Mellitus Tipo 1 Tratados com Múltiplas Administrações de Insulina e de Indivíduos sem Diabetes

et al. 2017

View full text Add to dashboard Cite

In addition to macro and microvascular complications that are associated with the disease, hyperglycaemia is also a risk factor for several oral complications. The aim of this study is to establish a relationship between dental caries in patients with type 1 diabetes mellitus treated with multiple insulin injections and that of individuals without diabetes. It is also an aim to characterize the oral hygiene habits of this population. Material and Methods:An observational clinical study of analytical and cross-sectional nature was conducted. Thirty patients with type 1 diabetes mellitus and 30 individuals without diabetes were observed and questioned about information regarding their medical history. Oral examination was conducted according to the standards of the World Health Organization and ICDAS was used for caries detection. Statistical analysis was performed and the significance level was set at 5%. Results: Patients with diabetes mellitus showed similar caries levels to that of individuals without diabetes. Patients with diabetes mellitus had a higher dental plaque index. Only 10% of the patients having episodes of nocturnal hypoglycaemia brush their teeth after glucose intake. Discussion: Although there's some controversy in the literature regarding the prevalence of caries in patients with diabetes mellitus, the results are in agreement with a great number of studies. However, patients with diabetes mellitus have a higher plaque index which can be associated with a higher risk for developing certain oral pathologies. Conclusion:No statistically significant association was found between type 1 diabetes mellitus and dental caries.

show abstract

“…NAFLD may be connected to autoimmune disease and mitophagy associated with impairment in insulin secretion and cardiovascular disease [18][19][20]. In Type 1 diabetes the use of insulin therapy has been assessed with the critical importance to reduce hyperglycemia, severe hypoglycemia and the development of long-term complications [21][22][23]. Insulin therapy should be carefully evaluated in Type 1 and Type 2 diabetes with relevance to reduction in plasma glucose levels [24].…”

Section: Diabetes and Pathogenetic Loop Complicationsmentioning

confidence: 99%

Insulin Therapy and Autoimmune Disease with Relevance to Non Alchoholic Fatty Liver Disease

Martins¹

2019

Nonalcoholic Fatty Liver Disease - An Update

View full text Add to dashboard Cite

The diabetes epidemic is now expected by the year 2050 to become a global pandemic with approx. 592 million affected in both the developed and developing world. The treatment of diabetes by insulin therapy has been the focus for many diabetics with the improvement and prevention of various diseases such as cardiovascular disease, kidney disease and neurodegeneration. The global nonalcoholic fatty liver disease (NAFLD) epidemic has now become of major concern to diabetes with critical interest in insulin therapy to reverse and stabilize autoimmune disease with relevance to NAFLD and the diabetes pandemic. Dietary components that activate anti-aging genes improve insulin therapy and should be assessed with specific amounts and doses of Indian spices consumed that may not interfere with insulin therapy and induce mitophagy in various diseases. Food quality, appetite control and core body temperature are critical to maintain insulin therapy with unhealthy diets linked to NAFLD and diabetes. Genomic medicine and dietary activators are essential to maintain insulin therapy and prevent toxic immune reactions with relevance to NAFLD and diabetes management.

show abstract

Insulin therapy

Cited by 4 publications

References 31 publications

A Dioxidovanadium Complex cis-[VO2 (obz) py] Attenuates Hyperglycemia in Streptozotocin (STZ)-Induced Diabetic Male Sprague-Dawley Rats via Increased GLUT4 and Glycogen Synthase Expression in the Skeletal Muscle

A Dioxidovanadium Complex cis-[VO2 (obz) py] Attenuates Hyperglycemia in Streptozotocin (STZ)-Induced Diabetic Male Sprague-Dawley Rats via Increased GLUT4 and Glycogen Synthase Expression in the Skeletal Muscle

Prevalência de Lesões de Cárie de Doentes com Diabetes Mellitus Tipo 1 Tratados com Múltiplas Administrações de Insulina e de Indivíduos sem Diabetes

Insulin Therapy and Autoimmune Disease with Relevance to Non Alchoholic Fatty Liver Disease

Contact Info

Product

Resources

About