Insulin Signaling in Bone Marrow Adipocytes

Tencerová, Michaela; Okla, Meshail; Kassem, Moustapha

doi:10.1007/s11914-019-00552-8

Cited by 26 publications

(20 citation statements)

References 85 publications

(109 reference statements)

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“…Insulin signaling is an evolutionarily conserved pathway that plays a pivotal role in the regulation of metabolism and longevity, and bone is an insulin-responsive organ. In T2D, impaired insulin signaling in peripheral tissues leads to insulin resistance ( 27 ). Thus, metabolic disturbances associated with diabetes increase the risk of fragility fractures along with increased bone marrow adiposity.…”

Section: Discussionmentioning

confidence: 99%

Association of Insulin Resistance and β-cell Function With Bone Turnover Biomarkers in Dysglycemia Patients

et al. 2021

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BackgroundThe interrelation between glucose and bone metabolism is complex and has not been fully revealed. This study aimed to investigate the association between insulin resistance, β-cell function and bone turnover biomarker levels among participants with abnormal glycometabolism.MethodsA total of 5277 subjects were involved through a cross-sectional study (METAL study, http://www.chictr.org.cn, ChiCTR1800017573) in Shanghai, China. Homeostasis model assessment of insulin resistance (HOMA-IR) and β-cell dysfunction (HOMA-%β) were applied to elucidate the nexus between β-C-terminal telopeptide (β-CTX), intact N-terminal propeptide of type I collagen (P1NP) and osteocalcin (OC). β-CTX, OC and P1NP were detected by chemiluminescence.ResultsHOMA-IR was negatively associated with β-CTX, P1NP and OC (regression coefficient (β) -0.044 (-0.053, -0.035), Q4vsQ1; β -7.340 (-9.130, -5.550), Q4vsQ1 and β -2.885 (-3.357, -2.412), Q4vsQ1, respectively, all P for trend <0.001). HOMA-%β was positively associated with β-CTX, P1NP and OC (β 0.022 (0.014, 0.031), Q4vsQ1; β 6.951 (5.300, 8.602), Q4vsQ1 and β 1.361 (0.921, 1.800), Q4vsQ1, respectively, all P for trend <0.001).ConclusionsOur results support that lower bone turnover biomarker (β-CTX, P1NP and OC) levels were associated with a combination of higher prevalence of insulin resistance and worse β-cell function among dysglycemia patients. It is feasible to detect bone turnover in diabetes or hyperglycemia patients to predict the risk of osteoporosis and fracture, relieve patients’ pain and reduce the expenses of long-term cure.

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Section: Discussionmentioning

confidence: 99%

Association of Insulin Resistance and β-cell Function With Bone Turnover Biomarkers in Dysglycemia Patients

et al. 2021

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“…Bone marrow adipose tissue (BMAT), which accounts for about 8% of total fat mass, is an important fat depot in the adult body and exerts a significant function in bone homeostasis and energy metabolism throughout the body ( Tencerova et al, 2019 ). BMAT is thought to be negatively correlated with bone density and bone integrity, so it may be an important regulator of bone turnover ( Fazeli et al, 2013 ).…”

Section: Bone Marrow Adipocytes and Bonementioning

confidence: 99%

Obesity and Bone Health: A Complex Link

Hou

et al. 2020

Front. Cell Dev. Biol.

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So far, the connections between obesity and skeleton have been extensively explored, but the results are inconsistent. Obesity is thought to affect bone health through a variety of mechanisms, including body weight, fat volume, bone formation/resorption, proinflammatory cytokines together with bone marrow microenvironment. In this review, we will mainly describe the effects of adipokines secreted by white adipose tissue on bone cells, as well as the interaction between brown adipose tissue, bone marrow adipose tissue, and bone metabolism. Meanwhile, this review also reviews the evidence for the effects of adipose tissue and its distribution on bone mass and bone-related diseases, along with the correlation between different populations with obesity and bone health. And we describe changes in bone metabolism in patients with anorexia nervosa or type 2 diabetes. In summary, all of these findings show that the response of skeleton to obesity is complex and depends on diversified factors, such as mechanical loading, obesity type, the location of adipose tissue, gender, age, bone sites, and secreted cytokines, and that these factors may exert a primary function in bone health.

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“…However, while this approach allowed for consideration of variability in the measured metabolic outputs across all treatments, the causal direction of these significant relationships could not be determined. Even so, insulin signaling may control metabolic programming of stem cells in bone marrow 21 . We examined both cell proportions and cell numbers in these tissues for a more complete phenotyping of HSPCs and myeloid cells.…”

Section: Discussionmentioning

confidence: 99%

Metabolic dysfunction induced by a high‐fat diet modulates hematopoietic stem and myeloid progenitor cells in brown adipose tissue of mice

Mincham

Panchal

Hart

et al. 2021

Immunol. Cell Biol.

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Brown adipose tissue (BAT) may be an important metabolic regulator of whole‐body glucose. While important roles have been ascribed to macrophages in regulating metabolic functions in BAT, little is known of the roles of other immune cells subsets, particularly dendritic cells (DCs). Eating a high‐fat diet may compromise the development of hematopoietic stem and progenitor cells (HSPCs)—which give rise to DCs—in bone marrow, with less known of its effects in BAT. We have previously demonstrated that ongoing exposure to low‐dose ultraviolet radiation (UVR) significantly reduced the ‘whitening’ effect of eating a high‐fat diet upon interscapular (i) BAT of mice. Here, we examined whether this observation may be linked to changes in the phenotype of HSPCs and myeloid‐derived immune cells in iBAT and bone marrow of mice using 12‐colour flow cytometry. Many HSPC subsets declined in both iBAT and bone marrow with increasing metabolic dysfunction. Conversely, with rising adiposity and metabolic dysfunction, conventional DCs (cDCs) increased in both of these tissues. When compared with a low‐fat diet, consumption of a high‐fat diet significantly reduced proportions of myeloid, common myeloid and megakaryocyte–erythrocyte progenitors in iBAT, and short‐term hematopoietic stem cells in bone marrow. In mice fed the high‐fat diet, exposure to low‐dose UVR significantly reduced proportions of cDCs in iBAT, independently of nitric oxide release from irradiated skin [blocked using the scavenger 2‐(4‐carboxyphenyl)‐4,4,5,5‐tetramethylimidazoline‐1‐oxyl‐3‐oxide potassium salt (cPTIO)], but did not significantly modify HSPC subsets in either tissue. Further studies are needed to determine whether changes in these cell populations contribute towards metabolic dysfunction .

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Insulin Signaling in Bone Marrow Adipocytes

Cited by 26 publications

References 85 publications

Association of Insulin Resistance and β-cell Function With Bone Turnover Biomarkers in Dysglycemia Patients

Association of Insulin Resistance and β-cell Function With Bone Turnover Biomarkers in Dysglycemia Patients

Obesity and Bone Health: A Complex Link

Metabolic dysfunction induced by a high‐fat diet modulates hematopoietic stem and myeloid progenitor cells in brown adipose tissue of mice

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