Insulin sensitivity, sodium-lithium countertransport and platelet free calcium concentrations in normotensive men with a family history of hypertension

Mattiasson, Ingrid; Endre, T; Berglund, Göran; Hulthén, U L

doi:10.1038/sj.jhh.1000585

Cited by 4 publications

(2 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This is in agreement with the observation that SLC was associated with peripheral insulin resistance in hypertensive men and women 25. Although this was not confirmed by other authors,30 glucose disposal in our study did not significantly correlate with SLC in both OHP and C. Unfortunately, the studies mentioned above did not investigate correlations between glucose disposal and other types of RBC ion transport because they were aimed at SLC only. The altered membrane lipid composition with resulting changes in membrane microviscosity might be the common factor underlying abnormal transmembrane cationic transport in hypertension31 and diabetes 32.…”

Section: Discussionsupporting

confidence: 85%

Erythrocyte Membrane Ion Transport in Offspring of Hypertensive Parents

Suchánková

Vlasáková

Zicha

et al. 2002

Annals of the New York Academy of Sciences

View full text Add to dashboard Cite

Some patients with essential hypertension exhibit insulin resistance (IR) and several red blood cell (RBC) ion transport abnormalities. The aims of the study were to assess RBC ion transport acitivities under basal conditions, to test in vivo the effect of acute hyperinsulinemia, and to evaluate the relationship to IR in the offspring of hypertensive parents (n= 12; OHP) and healthy controls (n= 14; C). Activities of the Na+‐K+ pump, Na+‐K+ cotransport, Na+‐Li+ countertransport (SLC), and Na+, Rb+, and Li+ leaks (passive membrane permeability) were measured before and after a hyperinsulinemic (75 μU/mL) euglycemic clamp (HIC) and compared to those found under isoinsulinemic isovolumic conditions in OHP and C. An insulin action was calculated as glucose disposal and insulin sensitivity index (M/I) after HIC. OHP were characterized by lower M/I (0.12±0.07 vs. 0.20±0.09 mg/kg/min/μU/mL; p < 0.05) and elevated SLC and Li+ and Rb+ leaks (p < 0.05) compared with C. Although acute hyperinsulinemia did not modify significantly any ion transport parameter studied, negative correlation was observed between insulin action and membrane cation leaks. Glucose disposal correlated with an Li+ leak in C (r=−0.736; p < 0.01) and all subjects (r=−0.424; p < 0.05) after HIC and in OHP with an Na+ leak (r=−0.727; p < 0.05) before HIC. In conclusion, OHP displayed higher insulin resistance, enhanced activity of SLC, and augmented Li+ and Rb+ leaks. Acute hyperinsulinemia did not modify any ion transport parameter studied, although negative correlation was observed between insulin action and membrane leaks.

show abstract

Section: Discussionsupporting

confidence: 85%

Erythrocyte Membrane Ion Transport in Offspring of Hypertensive Parents

Suchánková

Vlasáková

Zicha

et al. 2002

Annals of the New York Academy of Sciences

View full text Add to dashboard Cite

show abstract

“…This relationship has been described as being absent in other normotensive populations. 16,19 One previous study has examined SLC kinetics in patients (12 male, 36 female; average age 54.5 years) with familial hypercholesterolaemia. 20 In contrast to our study it included patients with a significantly increased systolic and diastolic blood pressures (systolic blood pressure = 146 ± 21 mm Hg; diastolic blood pressure = 88 ± 16 mm Hg) compared to controls.…”

Section: Journal Of Human Hypertensionmentioning

confidence: 99%

Effects of lipids in patients with familial hypercholesterolaemia on the kinetics of the sodium-lithium countertransporter

et al. 2000

View full text Add to dashboard Cite

Relation between sodium–lithium countertransport and hypertriglyceridemia in type V hyperlipidemia

Wierzbicki

Hardman

Cheung

et al. 2001

American Journal of Hypertension

View full text Add to dashboard Cite

Sodium-lithium countertransport (SLC) kinetics were measured in 30 patients with type V hyperlipidemia, 30 patients with type IIB hyperlipidemia on similar treatment, and 30 age- and sex-matched healthy controls. Clinical and laboratory data including basic anthropometry and blood pressure were obtained and blood was taken for detailed lipid biochemistry, glucose, insulin, and leptin measurements. Patients with type V hyperlipidemia were normotensive but more obese than controls, had elevated triglycerides, very low-density lipoprotein, glucose, and insulin; and reduced HDL cholesterol compared with type IIb controls. The median SLC activity (0.23 v 0.21 mmol Li+/L RBC/h) and median maximal velocity (0.33 v 0.31 mmol Li+/L RBC/h) were increased, but not significantly, compared to controls. In patients with type V hyperlipidemia SLC maximal velocity correlated with log triglycerides (r2 = 0.853; P < .001) and log very low-density lipoprotein (VLDL) triglycerides (r2 = 0.947; P < .001). Sodium-lithium countertransport maximal velocity correlated weakly with the homeostasis model assessment index of insulin resistance (r2 = 0.224; P = .06). The sodium affinity of the transporter did not differ between the groups and was independent of any of clinical or biochemical parameter studied. We conclude that VLDL triglyceride is strongly correlated with SLC maximal velocity and activity in patients with type V hyperlipidemia.

show abstract

Insulin sensitivity, sodium-lithium countertransport and platelet free calcium concentrations in normotensive men with a family history of hypertension

Cited by 4 publications

References 36 publications

Erythrocyte Membrane Ion Transport in Offspring of Hypertensive Parents

Erythrocyte Membrane Ion Transport in Offspring of Hypertensive Parents

Effects of lipids in patients with familial hypercholesterolaemia on the kinetics of the sodium-lithium countertransporter

Relation between sodium–lithium countertransport and hypertriglyceridemia in type V hyperlipidemia

Contact Info

Product

Resources

About