Effects of lipids in patients with familial hypercholesterolaemia on the kinetics of the sodium-lithium countertransporter

Wierzbicki, Anthony S.; Hardman, Timothy C.; Cheung, J; Lambert-Hammill, Michelle; Patel, S; Morrish, Z; Lumb, P J; Lant, A. F.

doi:10.1038/sj.jhh.1001097

Cited by 1 publication

(3 citation statements)

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“…[2][3][4][5]7,8,11,24 Sodium-lithium CT activity is also increased in patients with hyperlipidemia. [17][18][19][20]22 As mentioned earlier, Na + /Li + CT activity is independently and positively associated with plasma TG levels 12,13,25 and negatively related with plasma HDL-Chol levels 1,26 and membrane Chol concentrations. 14,15 In contrast, plasma Chol was directly 16 or inversely 14,15 associated with Na + /Li + CT.…”

Section: Discussionmentioning

confidence: 68%

“…Similar results were previously reported, though with a smaller effect (11%) on Na + /Li + CT activity 39 or a weaker association between Na + /Li + CT activity and plasma TG levels. 20 We also compared clinical, biochemical characteristics, and Na + /Li + CT activity in men and women. In the D/NT group, men had a significantly higher SBP (P = .023), DBP (P = .004), and TG levels (P < .001) but lower tChol levels (P < .001) compared with women.…”

Section: Discussionmentioning

confidence: 99%

“…Only a few studies compared Na + /Li + CT activity in hyperlipidemic patients [17][18][19][20] or compared Na + /Li + CT between HL/HPT, HL/NT patients, and controls. 21,22 The aim of our study was to evaluate the role of dyslipidemia in the determination of Na + /Li + CT activity in healthy and hypertensive individuals.…”

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confidence: 99%

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Sodium-Lithium Countertransport Activity in Healthy, Dyslipidemic, and Hypertensive Individuals

et al. 2008

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The aim of our study was to investigate the role of dyslipidemia on red blood cell sodium-lithium countertransport activity in healthy and hypertensive individuals. A total of 128 Caucasian individuals, aged 20 to 60 years old, were divided into 4 groups: dyslipidemic/ hypertensive, dyslipidemic/normotensive, normolipidemic/hypertensive, and normolipidemic/ normotensive (controls). Sodium-lithium countertransport activity was determined based on the Canessa et al method. Sodium-lithium countertransport activity was significantly higher in all patient groups compared with controls (P < .001) and similar in the 3 patient groups. Sodium-lithium countertransport activity was significantly and positively associated with triglyceride levels (P < .001), body mass index (P < .001), total cholesterol levels (P = .001), and systolic (P = .001) and diastolic blood pressure (P = .001). In multivariate regression analysis, triglycerides made the largest contribution to sodium-lithium countertransport variation among the variables tested (R(2) = 0.273). Our results suggest that dyslipidemia affects sodium-lithium countertransport activity independently of essential hypertension and even to a greater extent than hypertension.

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