Insulin sensitivity markers

Golomb, Beatrice A.; Tenkanen, Leena; Alikoski, Tiina; Niskanen, Tuomo; Manninen, Vesa; Huttunen, Matti; Mednick, Sarnoff A.

doi:10.1016/s0895-4356(02)00407-9

Cited by 65 publications

(11 citation statements)

References 49 publications

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“…The present results also agree with a prospective study reporting that accumulation of factors related to high insulin sensitivity is associated with an increased risk of suicide in a Finnish population (33). …”

Section: Discussionsupporting

confidence: 93%

“…In particular, we suggest that future research consider the possible physiologic pathway between inadequate insulin action and DepS through increased central serotonin production, as proposed by Golomb et al (33). Briefly, because insulin action may suppress postprandial mobilization of nonesterified fatty acids from adipose tissue, lower postprandial free fatty acid levels are expected in a state of low insulin secretion.…”

Section: Discussionmentioning

confidence: 77%

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Glycemia, Insulin Resistance, Insulin Secretion, and Risk of Depressive Symptoms in Middle Age

et al. 2013

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OBJECTIVEThe extent to which abnormal glucose metabolism increases the risk of depression remains unclear. In this study, we investigated prospective associations of levels of fasting glucose and fasting insulin and indices of insulin resistance and secretion with subsequent new-onset depressive symptoms (DepS).RESEARCH DESIGN AND METHODSIn this prospective cohort study of 3,145 adults from the Whitehall II Study (23.5% women, aged 60.6 ± 5.9 years), baseline examination included fasting glucose and insulin level, the homeostasis model assessment of insulin resistance (HOMA2-%IR), and the homeostasis model assessment of β-cell insulin secretion (HOMA2-%B). DepS (Center for Epidemiologic Studies Depression Scale ≥16 or use of antidepressive drugs) were assessed at baseline and at 5-year follow-up.RESULTSOver the 5-year follow-up, DepS developed in 142 men and 84 women. Women in the lowest quintile of insulin secretion (HOMA2-%B ≤55.3%) had 2.18 (95% CI 1.25–3.78) times higher odds of developing DepS than those with higher insulin secretion. This association was not accounted for by inflammatory markers, cortisol secretion, or menopausal status and hormone replacement therapy. Fasting insulin measures were not associated with DepS in men, and fasting glucose measures were not associated with new-onset DepS in either sex.CONCLUSIONSLow insulin secretion appears to be a risk factor for DepS in middle-aged women, although further work is required to confirm this finding.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 77%

Glycemia, Insulin Resistance, Insulin Secretion, and Risk of Depressive Symptoms in Middle Age

et al. 2013

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“…Low central serotonin has been linked to low cholesterol and to aggression [28, 78, 79]. However, whole blood serotonin (which correlates inversely to central serotonin) did not predict aggression in mediation analysis within a randomized trial [69].…”

Section: Discussionmentioning

confidence: 99%

Mood, Personality, and Behavior Changes During Treatment with Statins: A Case Series

Cham

Koslik

Golomb

2015

Drug Saf - Case Rep

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Psychiatric adverse drug reactions (ADRs) have been reported with statin use, but the literature regarding statin-associated mood/behavioral changes remains limited. We sought to elicit information germane to natural history and characteristics of central nervous system/behavioral changes in apparent connection with statin and/or cholesterol-lowering drug use, and delineate mechanisms that may bear on an association. Participants (and/or proxies) self-referred with behavioral and/or mood changes in apparent association with statins completed a survey eliciting cholesterol-lowering drug history, character and impact of behavioral/mood effect, time-course of onset and recovery in relation to drug use/modification, co-occurrence of recognized statin-associated ADRs, and factors relevant to ADR causality determination. Naranjo presumptive ADR causality criteria were assessed. Participants (n = 12) reported mood/behavior change that commenced following statin initiation and persisted or progressed with continued use. Reported problems included violent ideation, irritability, depression, and suicide. Problems resolved with drug discontinuation and recurred with rechallenge where attempted. Eight met presumptive criteria for “probable” or “definite” causality; others had additional factors not considered in Naranjo criteria that bear on casual likelihood. (1) Simvastatin 80 mg was followed in 5 days by irritability/depression culminating in suicide in a man in his 40s (Naranjo criteria: possible causality). (2) Simvastatin 10 mg was followed within 2 weeks by depression in a woman in her 50s (probable causality). (3) Atorvastatin 20 mg was followed in ~1 month by depression and irritability/aggression in a male in his 50s (probable causality). (4) Atorvastatin 10 mg was followed in several months by aggression/irritability and depression culminating in suicide in a man in his 40s (possible causality). (5) Fenofibrate + rosuvastatin (unknown dose), later combined with atorvastatin were followed in 1 month by aggression/irritability in a male in his 30s (probable causality). (6) Lovastatin (unknown dose and time-course to reaction) was followed by depression, dyscontrol of bipolar disorder, and suicide attempts in a male in his 40s (possible causality). (7) Atorvastatin 20 mg was followed within 2 weeks by cognitive compromise, and nightmares, depression, and anxiety culminating in suicide in a man in his teens (definite causality). (8) Simvastatin 10 mg was followed (time-course not recalled) by depression, aggression/irritability culminating in suicide in a man in his 60s (possible causality). (9) Simvastatin 20 mg then atorvastatin 10 mg were followed (time-course not provided) by irritability/aggression in a man in his 60s (definite causality). (10) Atorvastatin 10 then 20 then 40 mg were followed shortly after the dose increase by violent ideation and anxiety in a man in his 30s (probable causality). (11) Atorvastatin 20 mg and then simvastatin 20 mg were followed in 2 weeks by aggression/irritability in a man in his...

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“…In summary, while many of the aforementioned studies point towards an inverse relationship between BMI and risk of completed suicide, the relationship remains equivocal and may depend on demographics such as sex or ethnicity. Moreover, the potential explanations for this apparent paradoxical inverse relationship remains unclear, with authors suggesting several potential mediating or correlative factors including impulsivity and case-fatality in relation to the chosen method of suicide [ 26 , 37 ], serum levels of cholesterol and its relation to central serotonin [ 8 ], leptin and leptin resistance [ 38 , 39 ], an insulin resistance based model [ 40 ], and dietary factors such as essential fatty acid intake [ 41 ].…”

Section: Introductionmentioning

confidence: 99%

Association between body mass index and suicidal behaviors: a systematic review protocol

et al. 2015

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BackgroundSuicide is among the leading causes of death worldwide. Suicide attempts and suicidal ideation are more common than completed suicide and are associated with psychological distress. These behaviors are considered risk factors of completed suicide. Considering the psychosocial stigma and medical comorbidities associated with obesity, an accumulating body of studies have investigated body mass index (BMI) as a potential risk factor of suicide. However, several cohort studies have demonstrated an inverse relationship between BMI and completed suicide, suggesting a protective effect of increasing BMI against completed suicide. The association between BMI and attempted suicide is more equivocal, with several studies reporting both positive and negative relationships between BMI and attempted suicide. The primary objective of this study is to systematically review the literature to determine the association between BMI and suicidal behavior (including completed suicide, attempted suicide, suicidal ideation) in an adult population (18 years and older). The secondary objective is to explore whether sex, age, and the method used in suicide modify the relationship between BMI and suicidal behavior.Methods/designAn electronic search will be conducted using PubMed/MEDLINE, PsycINFO, CINAHL, and EMBASE using a predefined search strategy; databases will be searched from their inception. Two authors (SP and RE) will independently screen articles using predefined inclusion and exclusion criteria and will extract pertinent data using a pilot tested extraction form. At all levels of screening, discrepancies between the two authors will be resolved by consensus, and in the case of disagreement, by consulting a third author (ZS). The primary outcomes include the association between BMI and completed suicide, attempted suicide, and suicidal ideation. If appropriate, a meta-analysis will be conducted. Risk of bias and quality of evidence will be assessed.DiscussionThe results of this systematic review will inform health care professionals and researchers about whether BMI has a significant role in suicidal behavior and psychological well-being.Systematic review registrationPROSPERO CRD42014014739.Electronic supplementary materialThe online version of this article (doi:10.1186/s13643-015-0038-y) contains supplementary material, which is available to authorized users.

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Insulin sensitivity markers

Cited by 65 publications

References 49 publications

Glycemia, Insulin Resistance, Insulin Secretion, and Risk of Depressive Symptoms in Middle Age

Glycemia, Insulin Resistance, Insulin Secretion, and Risk of Depressive Symptoms in Middle Age

Mood, Personality, and Behavior Changes During Treatment with Statins: A Case Series

Association between body mass index and suicidal behaviors: a systematic review protocol

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