Glycemia, Insulin Resistance, Insulin Secretion, and Risk of Depressive Symptoms in Middle Age

Akbaraly, Tasnime; Head, Jenny; Ritchie, Karen; Ancelin, Marie-Laure; Tabák, Ádám G.; Brunner, Eric J.; Chaudieu, Isabelle; Marmot, Michael; Ferrie, Jane E.; Shipley, Martin J.; Kivimäki, Mika

doi:10.2337/dc12-0239

Cited by 25 publications

(19 citation statements)

References 35 publications

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“…Future longitudinal studies should investigate the causal processes between depression and reduced handgrip strength. Potential moderating and mediating biological mechanisms, such as mitochondrial dysfunction (42, 43) chronic low-grade inflammation (44, 45) hyperglycemia (46, 47), or elevated leptin secretion (48, 49), which have been found in both sarcopenia and depression among middle-aged adults and older adults should be further evaluated. Psychosocial factors, such as aging-related adjustment reaction or limited social support, that may influence the ability to cope with the mental and physical health consequences of reduced handgrip strength could also be explored.…”

Section: Discussionmentioning

confidence: 99%

Depression and Handgrip Strength Among U.S. Adults Aged 60 Years and Older from NHANES 2011â€“2014

Brooks

Titus

Bruce

et al. 2018

The Journal of nutrition, health and aging

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Objectives Sarcopenia is a gradual loss of muscle mass and strength that occurs with aging. This muscle deterioration is linked to increased morbidity, disability, and other adverse outcomes. Although reduced handgrip strength can be considered a marker of sarcopenia and other aging-related decline in the elderly, there is limited research on this physical health problem in at-risk groups with common biopsychosocial conditions such as depression. Our primary objective was to ascertain level of combined handgrip strength and its relationship with depression among adults aged 60 years and older. Design Unadjusted and adjusted linear regression models were conducted with a cross-sectional survey dataset. Setting Secondary dataset from the 2011–2014 National Health and Nutrition Examination Survey (NHANES). Participants Community-dwelling, non-institutionalized adults ≥ 60 years old (n=3,421). Measurements The predictor variables included a positive screen for clinically relevant depression (referent=PHQ-9 score <10). The criterion variable of combined handgrip strength (kg) was determined using a dynamometer. Results Mean age and BMI were 69.9 years (51.5% female) and 28.8 kg/m2, respectively. Mean combined handgrip strength in the overall cohort was 73.5 and 46.6 kg in males and females, respectively. Three hundred thirty-six (9.8%) reported symptoms of depression. In unadjusted and fully adjusted models, depression was significantly associated with reduced handgrip strength (B = −0.26±0.79 and B = −0.19±0.08, respectively; p<0.001). Conclusion Our findings demonstrate handgrip strength has a significant inverse association with depression. Future longitudinal studies should investigate the causal processes and potential moderators and mediators of the relationships between depression and reduced handgrip strength. This information may further encourage the use of depression and handgrip strength assessments and aid in the monitoring and implementation of health care services that address both physical and mental health limitations among older adult populations.

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Section: Discussionmentioning

confidence: 99%

Depression and Handgrip Strength Among U.S. Adults Aged 60 Years and Older from NHANES 2011â€“2014

Brooks

Titus

Bruce

et al. 2018

The Journal of nutrition, health and aging

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“…In addition, the incidence of diabetes mellitus did not differ between patients with PD with and without depression (Icks et al, 2013 ). This is probably because the depressive systems are mainly correlated with impaired insulin sensitivity (Li et al, 2016 ) or low insulin secretion (Akbaraly et al, 2013 ), and the risk of depression gradually increases along with the deterioration of glucose metabolism (Chen et al, 2016 ).…”

Section: Discussionmentioning

confidence: 99%

“…The second most significantly altered metabolic pathway was “incretin synthesis, secretion, and inactivation,” which is related to glucose metabolism. The decreased secretion and sensitivity level of insulin, another common hypoglycemic hormone, appears to be a risk factor for depression (Akbaraly et al, 2013 ; Li et al, 2016 ). However, this is the first report of the synthesis, secretion, and inactivation of incretin involved in patients with PDD, and the relationship between incretin and depressive symptoms in patients with PD needs further clarification.…”

Section: Discussionmentioning

confidence: 99%

Integrated Analysis Reveals Altered Lipid and Glucose Metabolism and Identifies NOTCH2 as a Biomarker for Parkinson's Disease Related Depression

Dong

Feng

et al. 2018

Front. Mol. Neurosci.

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Depression is a common comorbidity in Parkinson's disease (PD) but is underdiagnosed. We aim to investigate the altered metabolic pathways of Parkinson's disease-related depression (PDD) in plasma and to identify potential biomarkers for clinical diagnosis. Consecutive patients with PD were recruited, clinically assessed, and patients with PDD identified. Fasting plasma samples were collected from 99 patients and differentially expressed metabolites and proteins between patients with PDD and PD were identified using non-targeted liquid chromatography-mass spectrometry (LC-MS)-based metabolomics and tandem mass tag (TMT)-based proteomics analysis, followed by an integrated analysis. Based on the above results, enzyme-linked immune sorbent assay (ELISA) tests were then performed to identify potential biomarkers for PDD. In clinics, patients with PDD suffered less hypertension and had lower serum low-density lipoprotein cholesterol and apolipoprotein B levels when compared to the other patients with PD. A total of 85 differentially expressed metabolites were identified in metabolomics analysis. These metabolites were mainly lipids and lipid-like molecules, involved in lipid and glucose metabolic pathways. According to proteomics analysis, 17 differentially expressed proteins were identified, and 12 metabolic pathways were enriched, which were predominantly related to glucose metabolism. Integrated analysis indicated that altered lipid and glucose metabolism in PDD may induce cellular injury through oxidative stress. Additionally, plasma levels of several proteins were confirmed to be significantly altered and correlated with depressive severity. NOTCH2 may be a potential blood biomarker for PDD, with an optimal cut-off point of 0.91 ng/ml, a sensitivity value of 95.65%, and a specificity value of 81.58%. Depressive symptoms are associated with lipid and glucose metabolism in patients with PD and NOTCH2 may be a potential blood biomarker for the clinical diagnosis of PDD.

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“…A recent meta-analysis reported an association between depression and insulin resistance [ 21 ]. The role of insulin secretion is more obscure, though a longitudinal study found that low insulin secretion is a risk factor for depression in middle-aged women [ 22 ]. Hyperglycaemia and insulin resistance may increase the risk of depression and also the risk of suicide, thus, we decided to study the associations between suicidal behaviour and disturbances in glucose metabolism in depressive patients that had been referred to depression nurse case managers.…”

Section: Introductionmentioning

confidence: 99%

Association between suicidal behaviour and impaired glucose metabolism in depressive disorders

et al. 2015

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BackgroundDisturbances in lipid metabolism have been linked to suicidal behaviour, but little is known about the association between suicide risk and abnormal glucose metabolism in depression. Hyperglycaemia and hyperinsulinaemia may increase the risk of depression and also the risk for suicide, we therefore studied associations between suicidal behaviour and disturbances in glucose metabolism in depressive patients who had been referred to depression nurse case managers.MethodsPatients aged 35 years and older (N = 448, mean age 51 years) who were experiencing a new depressive episode, who were referred to depression nurse case managers in 2008–2009 and who scored ≥10 on the Beck Depression Inventory were enrolled in this study. The study was conducted in municipalities within the Central Finland Hospital District (catchment area of 274 000 inhabitants) as part of the Finnish Depression and Metabolic Syndrome in Adults study. The patients’ psychiatric diagnoses and suicidal behaviour were confirmed by the Mini-International Neuropsychiatric Interview. Blood samples, for glucose and lipid determinations, were drawn from participants after 12 h of fasting, which was followed by a 2-hour oral glucose tolerance test (OGTT) when blood was drawn at 0 and 2 h. Insulin resistance was measured by the Quantitative Insulin Sensitivity Check Index (QUICKI) method.ResultsSuicidal ideation (49 %) and previous suicide attempts (16 %) were common in patients with major depressive disorder or dysthymia. Patients with depression and suicidal behaviour had higher blood glucose concentrations at baseline and at 2 hours in the OGTT. Glucose levels associated positively with the prevalence of suicidal behaviour, and the linearity was significant at baseline (p for linearity: 0.012, adjusted for age and sex) and for 2-hour OGTT glucose (p for linearity: 0.004, adjusted for age and sex). QUICKI levels associated with suicidal behavior (p for linearity across tertiles of QUICKI: 0.026). Total and LDL cholesterol and triglyceride levels were also higher in those patients with suicidal behaviour. Multivariate analysis revealed that blood glucose levels, BDI scores and antidepressive medications associated with suicidal behaviour.ConclusionInsulin resistance and disturbances in glucose and lipid metabolism may be more common in middle-aged depressive patients with suicidal behaviour.

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Glycemia, Insulin Resistance, Insulin Secretion, and Risk of Depressive Symptoms in Middle Age

Cited by 25 publications

References 35 publications

Depression and Handgrip Strength Among U.S. Adults Aged 60 Years and Older from NHANES 2011â€“2014

Depression and Handgrip Strength Among U.S. Adults Aged 60 Years and Older from NHANES 2011â€“2014

Integrated Analysis Reveals Altered Lipid and Glucose Metabolism and Identifies NOTCH2 as a Biomarker for Parkinson's Disease Related Depression

Association between suicidal behaviour and impaired glucose metabolism in depressive disorders

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