Insulin Sensitivity is Impaired in Patients with Migraine

Rainero, Innocenzo; Limone, Paolo Piero; Ferrero, Maria Elena; Valfrè, Walter; Pelissetto, C; Rubino, Elisa; Gentile, Salvatore; Giudice, R Lo; Pinessi, Lorenzo

doi:10.1111/j.1468-2982.2005.00928.x

Cited by 102 publications

(116 citation statements)

References 23 publications

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“…Migraine is a disease with a presumed vascular mechanism. 3 Recently, several epidemiologic, longitudinal, case-control, and cohort studies demonstrated association between migraine and vascular risk comorbid medical conditions including: increased body mass index (BMI) or obesity, 4 hypercholesterolemia/dyslipidemia, 5 hypertension, 6 impaired insulin sensitivity, 7 ischemic stroke in young adults, 8 and coronary heart disease. 9 These associations or comorbidities are not explained by bias.…”

mentioning

confidence: 99%

Vascular Risk Factors, Endothelial Function, and Carotid Thickness in Patients with Migraine: Relationship to Atherosclerosis

Hamed

Eldin

et al. 2010

Journal of Stroke and Cerebrovascular Diseases

113

132

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mentioning

confidence: 99%

Vascular Risk Factors, Endothelial Function, and Carotid Thickness in Patients with Migraine: Relationship to Atherosclerosis

Hamed

Eldin

et al. 2010

Journal of Stroke and Cerebrovascular Diseases

113

132

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“…[3][4][5][6] Sphingolipids (e.g., sphingomyelins, ceramides) are a group of bioactive lipids that are critical components of membrane microdomains. 7,8 In addition to important structural roles, these…”

Section: Classification Of Evidencementioning

confidence: 99%

Interictal, circulating sphingolipids in women with episodic migraine

et al. 2015

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Objective: To evaluate interictal, circulating sphingolipids in women migraineurs.Methods: In the fasting state, serum samples were obtained pain-free from 88 women with episodic migraine (EM; n 5 52) and from controls (n 5 36). Sphingolipids were detected and quantified by high-performance liquid chromatography coupled with tandem mass spectrometry using multiple reaction monitoring. Multivariate logistic regression was used to examine the association between serum sphingolipids and EM odds. A recursive partitioning decision tree based on the serum concentrations of 10 sphingolipids was used to determine the presence or absence of EM in a subset of participants.Results: Total ceramide (EM 6,502.9 ng/mL vs controls 10,518.5 ng/mL; p , 0.0001) and dihydroceramide (EM 39.3 ng/mL vs controls 63.1 ng/mL; p , 0.0001) levels were decreased in those with EM as compared with controls. Using multivariate logistic regression, each SD increase in total ceramide (odds ratio [OR] 0.07; 95% confidence interval [CI]: 0.02, 0.22; p , 0.001) and total dihydroceramide (OR 0.05; 95% CI: 0.01, 0.21; p , 0.001) levels was associated with more than 92% reduced odds of migraine. Although crude sphingomyelin levels were not different in EM compared with controls, after adjustments, every SD increase in the sphingomyelin species C18:0 (OR 4.28; 95% CI: 1.87, 9.81; p 5 0.001) and C18:1 (OR 2.93; 95% CI: 1.55, 5.54; p 5 0.001) was associated with an increased odds of migraine. Recursive portioning models correctly classified 14 of 14 randomly selected participants as EM or control. Conclusion:These results suggest that sphingolipid metabolism is altered in women with EM and that serum sphingolipid panels may have potential to differentiate EM presence or absence. Classification of evidence:This study provides Class III evidence that serum sphingolipid panels accurately distinguish women with migraine from women without migraine. Neurology ® 2015;85:1214-1223 GLOSSARY BMI 5 body mass index; C1P 5 ceramide-1-phosphate; CI 5 confidence interval; DHC 5 dihydroceramide; DHSM 5 dihydrosphingomyelin; DSM-IV 5 Diagnostic and Statistical Manual of Mental Disorders (Fourth Edition); EM 5 episodic migraine; HIT-6 5 Headache Impact Test-6; LacCer 5 lactosylceramide; MHC 5 monohexosylceramide; OPLS-DA 5 orthogonal partial least squares discriminant analysis; OR 5 odds ratio; PHQ-9 5 Patient Health Questionnaire-9; S1P 5 sphingosine-1-phosphate; SM 5 sphingomyelin.Although the full pathophysiology of migraine is not known, current theories suggest that migraine is largely an inherited brain disorder associated with a sterile, neurogenic inflammation and alterations in neuronal excitability and the cerebrovasculature.1,2 Several lines of evidence also indicate that migraineurs have a greater risk of stroke and disorders related to lipid metabolism including hypercholesterolemia, impaired insulin sensitivity, and obesity. [3][4][5][6] Sphingolipids (e.g., sphingomyelins, ceramides) are a group of bioactive lipids that are critical components of m...

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“…Moreover, Okada et al [816] demonstrated higher levels of lactic acid and pyruvic acid in the plasma of patients with migraine as compared with controls, which indicated mitochondrial function abnormalities in carbohydrate and fats metabolism, including tricarboxylic acid cycle. In addition, insulin sensitivity was found to be impaired in the patients with migraine as compared with normal individuals (P < 0.001) [817,818]. Therefore, its seems that there is a relationship between migraine/other types of headache and T1DM/T2DM, especially that many patients with recurrent headaches/migraine were found to be seropositive for T. gondii [819,820] and about two billion of people worldwide are chronically infected with the parasite.…”

Section: Possible Association Between Diabetes Migraine/other Type Omentioning

confidence: 98%

T. gondii Infection Acquired during Pregnancy and/or after Birth may be Responsible for Development of both Type 1 and 2 Diabetes Mellitus

Pr¹,

ota²

2013

J Diabetes Metab

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Recently, it was suggested that maternal T and potentially B cells transferred during pregnancy and/or the breast milk feeding and their encounter with the antigen in mesenteric lymph nodes might play a role in development of type 1 diabetes mellitus (T1DM). T. gondii infection during gestation and/or after birth may be responsible for development of both T1DM and T2DM in children, adolescents and adults because: a) maternal microchimerism in peripheral blood was demonstrated to be significantly higher in patients with T1DM compared to unaffected siblings and healthy subjects, b) transmission of T. gondii as a Trojan horse in various types of eukaryotic cells, including T and B lymphocytes, c) swallowing by the fetus of amniotic fluid containing infected leukocytes and other cells, d) elimination of T. gondii in the breast milk during lactation, e) involvement of mesenteric lymph nodes after oral infection with the parasite, and f) damage of the myenteric neurons during infection with the parasite in both the animals with streptozotocin-induced diabetes and diabetic patients. Moreover, a significantly lower occurrence of antibodies against T. gondii found in the sera of patients with T1DM compared with their first-degree family members or healthy controls may be due to their T and/or B cell exhaustion perspective caused by chronic infection with the parasite. This suggestion may be supported by the finding that latent toxoplasmosis was associated with markedly reduced lymphocyte B-cell counts responsible for production of antibodies, markedly lower serum IgG, IgM, and IgA levels, and a significant suppression of IL-2. On the other hand, patients with T2DM had increased anti-T. gondii antibodies significantly more frequently than respective controls. Impaired vascular endothelial function characteristic for the patients with diabetes mellitus may be at least in part due to the preferential T. gondii infection of endothelial cells. Vitamin D and minocycline exerted beneficial effects on development and clinical course of diabetes mellitus probably because of their immunomodulatory and antitoxoplasmatic activities. These data strongly suggest that the parasite play an important role in development of both types of diabetes mellitus.

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Insulin Sensitivity is Impaired in Patients with Migraine

Cited by 102 publications

References 23 publications

Vascular Risk Factors, Endothelial Function, and Carotid Thickness in Patients with Migraine: Relationship to Atherosclerosis

Vascular Risk Factors, Endothelial Function, and Carotid Thickness in Patients with Migraine: Relationship to Atherosclerosis

Interictal, circulating sphingolipids in women with episodic migraine

T. gondii Infection Acquired during Pregnancy and/or after Birth may be Responsible for Development of both Type 1 and 2 Diabetes Mellitus

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