Insulin sensitivity, insulin secretion, and glucose effectiveness in obese subjects: A minimal model analysis

Taniguchi, Ataru; Nakai, Yukie; Doi, Kentaro; Fukuzawa, Hiroaki; Fukushima, Mitsuo; Kawamura, Hideo; Tokuyama, Kumpei; Suzuki, Masashige; Fujitani, J.; Tanaka, Hiroaki; Nagata, I

doi:10.1016/0026-0495(95)90136-1

Cited by 43 publications

(27 citation statements)

References 36 publications

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“…Similar results were reported by Taniguchi et al, 25,26 demonstrating that Japanese patients with IGT had impaired ␤-cell function as well as reduced glucose sensitivity (SG) and (GEZI). On the other hand, Finegood and Tzur 27 indicated that insulin secretory function itself influenced estimates of SG.…”

Section: Discussionsupporting

confidence: 88%

“…The 20 mU kg Ϫ1 of insulin has been employed before by us and by others. 17,25,26,30 In summary, we have demonstrated that in non-obese Japanese women with former GDM, glucose tolerance (Kg), acute insulin secretion, and glucose effectiveness at zero insulin were significantly lower than normal, although insulin sensitivity was normal. These results indicate that deterioration of acute ␤-cell responses to glucose and tissue glucose sensitivity rather than tissue insulin sensitivity may be pathogenic factors in the development Type 2 DM in Japanese former GDM.…”

Section: Discussionmentioning

confidence: 95%

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No deterioration in insulin sensitivity, but impairment of both pancreatic β-cell function and glucose sensitivity, in Japanese women with former gestational diabetes mellitus

et al. 1998

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To identify the primary pathogenic factors involved in the development of Type 2 diabetes mellitus (DM), we studied Japanese women with former gestational diabetes mellitus (GDM) who are at risk for the later development of Type 2 DM. We used the minimal model analysis derived from frequently sampled intravenous glucose tolerance test (FSIGT). The subjects consisted of eight non-obese women with a history of GDM and eight non-obese normal women as control subjects. The 75 g oral glucose tolerance test (75 g OGTT) performed within 6 months of delivery confirmed that all the subjects with former GDM had a normal glucose tolerance. Insulin sensitivity (SI) derived from the minimal model analysis was not different between the two groups. Glucose effectiveness at zero insulin (GEZI), reflecting tissue glucose sensitivity, was significantly lower in former GDM patients than in control subjects (1.18+/-0.34 vs 2.26+/-0.29 x 10(-2) min(-1), p < 0.05). The early phase insulin secretion found in FSIGT was markedly reduced to 56% of that observed in control subjects (1250+/-87.4 vs 2223+/-304.3 pmol l(-1) min, p < 0.01). Our results indicate that in former GDM patients, who are japanese and non-obese, impairment of the acute insulin response to glucose and a decrease in tissue glucose sensitivity rather than insulin sensitivity are the primary pathogenic factors involved.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 95%

No deterioration in insulin sensitivity, but impairment of both pancreatic β-cell function and glucose sensitivity, in Japanese women with former gestational diabetes mellitus

et al. 1998

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“…Their age and BMI levels (mean ± SEM) were 60.9 ± 1.0 years and 22.9 ± 0.2 kg/m 2 (range 20.1-26.6), respectively. They were all nonobese (12). The duration of diabetes was 9.4 ± 0.7 years (range 1-32) and the HbA 1c level was 7.1 ± 0.2% (range 5.5-13.9%).…”

Section: Research Design Andmentioning

confidence: 99%

Remnant-like particle cholesterol, triglycerides, and insulin resistance in nonobese Japanese type 2 diabetic patients.

Taniguchi¹,

Fukushima²,

Sakai³

et al. 2000

Diabetes Care

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Abbreviations: CHD, coronary heart disease; CV, coefficient of variation; HOMA-IR, insulin resistance index of the homeostasis model assessment; RLP, remnant-like particle.A OBJECTIVE -The aim of the study was to investigate the relationships between remnantlike particle (RLP) cholesterol, triglycerides, and insulin resistance in nonobese Japanese type 2 diabetic patients. RESEARCH DESIGN AND METHODS-A total of 86 nonobese Japanese type 2 diabetic patients (72 men and 14 women, aged 40-83 years, BMI 20.1-26.6 kg/m 2 ) were studied. BMI, HbA 1c levels, and fasting concentrations of plasma glucose, serum lipids (RLP cholesterol, total cholesterol, HDL cholesterol, and triglycerides), and serum insulin were measured. Insulin resistance was estimated by the homeostasis model assessment (HOMA-IR). The subjects were divided into two groups according to the value of HOMA-IR. Values Ͼ2.5 were indicative of the insulin-resistant state, and values Ͻ2.5 were indicative of the insulin-sensitive state.RESULTS -The insulin-resistant group had significantly higher RLP cholesterol and triglyceride levels and lower HDL cholesterol levels compared with the insulin-sensitive group. Univariate regression analysis showed that insulin resistance was positively correlated with BMI (r = 0.254, P = 0.019), HbA 1c levels (r = 0.278, P = 0.011), RLP cholesterol levels (r = 0.315, P = 0.004), and triglyceride levels (r = 0.332, P = 0.002) and was negatively correlated with HDL cholesterol levels (r = Ϫ0.301, P = 0.006) in our diabetic patients. Multiple regression analysis showed that insulin resistance was independently associated with serum triglyceride levels, which explained 13.5% of the variability of insulin resistance in our nonobese Japanese type 2 diabetic patients.CONCLUSIONS -These results indicate that 1) nonobese Japanese type 2 diabetic patients with insulin resistance are characterized by high RLP cholesterol and triglyceride levels, and low HDL cholesterol levels; and 2) the level of serum triglycerides is an independent predictor of insulin resistance in these patients.

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“…They were all nonobese [22]. The fasting plasma glucose was 141 F 3 mg/dL, and glycosylated hemoglobin (HbA1c) was 7.0% F 0.1%.…”

Section: Resultsmentioning

confidence: 99%

Three measures of tumor necrosis factor α activity and insulin resistance in nonobese Japanese type 2 diabetic patients

Ohya¹,

Taniguchi²,

Fukushima

et al. 2005

Metabolism

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Insulin sensitivity, insulin secretion, and glucose effectiveness in obese subjects: A minimal model analysis

Cited by 43 publications

References 36 publications

No deterioration in insulin sensitivity, but impairment of both pancreatic β-cell function and glucose sensitivity, in Japanese women with former gestational diabetes mellitus

No deterioration in insulin sensitivity, but impairment of both pancreatic β-cell function and glucose sensitivity, in Japanese women with former gestational diabetes mellitus

Remnant-like particle cholesterol, triglycerides, and insulin resistance in nonobese Japanese type 2 diabetic patients.

Three measures of tumor necrosis factor α activity and insulin resistance in nonobese Japanese type 2 diabetic patients

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