Remnant-like particle cholesterol, triglycerides, and insulin resistance in nonobese Japanese type 2 diabetic patients.

Taniguchi, Ataru; Fukushima, Mitsuo; Sakai, Masahiko; Miwa, Kunihisa; Makita, Toshinori; Nagata, I; Nagasaka, Shoichiro; Doi, Kentaro; Okumura, Takako; Fukuda, Akira; Kishimoto, Hiroyuki; Фукуда, Такуо; Nakaishi, Shigeo; Tokuyama, Kumpei; Nakai, Yoshikatsu

doi:10.2337/diacare.23.12.1766

Cited by 90 publications

(68 citation statements)

References 36 publications

(26 reference statements)

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“…It is interesting to note that other common lab values associated with obesity, such as Hemoglobin A1C levels did not add to the prediction of IR. Therefore, although some clinicians and researchers have advocated for the potential of using Hemoglobin A1C as a predictor of IR and/ or diabetes [32,33], we found no support for this among a large community-residing, non-clinical adolescents of color carrying excess weight.…”

Section: Discussioncontrasting

confidence: 51%

How Should we Screen Overweight and Obese Adolescents for Risk of Type 2 Diabetes in Large Public Health Initiatives?

R¹,

J-M²,

Baltadzhieva³

et al. 2016

Journal of Obesity and Overweight

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Decline in the biological response to insulin in the presence of normal or high blood concentrations of the hormone is called insulin resistance (IR) [1]. This could be reflective of an insensitivity of peripheral tissues (e.g., muscle, liver, adipose tissue) to the effects of insulin [2] or due to reduction in the maximal response to the hormone [1]. Obesity in adults is linked to IR. In 2011-2012, the US prevalence of overweight/obese children 12-19 years old of all races was 34.5% [3]. Excess weight in youth is a strong predictor of excess weight in adulthood [4,5]. It also is associated with an increased risk of cardiovascular disease and type 2 diabetes [6,7] and a greater likelihood of mortality from those conditions [8]. Furthermore, even among individuals with normal Abstract Purpose: To develop a valid method to identify insulin resistance (IR) in overweight and obese adolescents without requiring a fasting blood sample.

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Section: Discussioncontrasting

confidence: 51%

How Should we Screen Overweight and Obese Adolescents for Risk of Type 2 Diabetes in Large Public Health Initiatives?

R¹,

J-M²,

Baltadzhieva³

et al. 2016

Journal of Obesity and Overweight

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show abstract

“…The HOMA-IR was calculated with the formula: IRI (µU/mL) × FPG (mmol/l)/ 22.5. We used the value of 2.5 as the threshold for IR (9). Patients were divided into two groups according to IR.…”

Section: Lipid Measurements and Calculationsmentioning

confidence: 99%

Relationship between Insulin Resistance and Effect of Atorvastatin in Non-diabetic Subjects

Yoshitomi¹,

Ishii

Kaneki³

et al. 2005

JAT

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“…Visceral fat accumulation is also associated with serum triglyceride (TG) levels, and the disturbance of TG metabolism precedes the development of insulin resistance in nonobese Japanese type 2 diabetic patients (9,10). However, the relationships of visceral adiposity and TG metabolism with insulin resistance in Japanese MONW subjects with normal glucose tolerance have not been evaluated.…”

mentioning

confidence: 99%

Increased Visceral Fat and Serum Levels of Triglyceride Are Associated With Insulin Resistance in Japanese Metabolically Obese, Normal Weight Subjects With Normal Glucose Tolerance

et al. 2003

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OBJECTIVE -The purpose of this study was to investigate the association between visceral adiposity or triglyceride (TG) metabolism and insulin resistance in metabolically obese, normal weight (MONW) Japanese individuals with normal glucose tolerance.RESEARCH DESIGN AND METHODS -We evaluated body fat areas, lipid profiles, and the glucose infusion rate (GIR) during a euglycemic-hyperinsulinemic clamp study in 20 MONW subjects (BMI Ͻ25 kg/m 2 and visceral fat areas 100 cm 2 ) with normal glucose tolerance. Body fat areas were measured by computed tomography scans. Control data were obtained from 20 normal subjects (BMI Ͻ25 kg/m 2 and visceral fat areas Ͻ100 cm 2 ).RESULTS -MONW subjects showed a significant increase in fasting serum levels of TG (P Ͻ 0.01) and a decrease in GIR (P Ͻ 0.01) compared with normal subjects. There were significant correlations between visceral fat areas (r ϭ Ϫ0.563, P Ͻ 0.01) or serum levels of TG (r ϭ Ϫ0.474, P Ͻ 0.05) and GIR in MONW subjects. Multiple regression analyses showed that visceral fat areas (F ϭ 7.702, P Ͻ 0.02) and serum levels of TG (F ϭ 7.114, P Ͻ 0.05) were significantly associated with GIR in all (MONW and normal) subjects.CONCLUSIONS -Increased visceral fat and serum levels of TG are associated with insulin resistance in Japanese MONW subjects with normal glucose tolerance. Excess visceral fat and elevated TG levels may play important roles in the development of insulin resistance in Japanese MONW subjects with normal glucose tolerance. Diabetes Care 26:2341-2344, 2003R ecent reports described the existence of individuals with normal body weight but with a cluster of obesity-related characteristics (1,2). They are characterized by excess visceral fat, insulin resistance, and hyperinsulinemia and have been called metabolically obese, normal weight (MONW) subjects. Ethnic differences should be considered for identifying MONW subjects. In the Japanese population, nonobese (BMI Ͻ25 kg/ m 2 ) subjects with increased visceral fat areas (100 cm 2 ) fulfill the criteria for categorizing them in the MONW group (2-6). Regarding the association of the MONW state with diabetes, higher prevalence of hyperglycemia has been observed in MONW subjects than in normal individuals (3,4).Previous studies have demonstrated that visceral fat areas are associated with insulin resistance in Japanese subjects with normal glucose tolerance and impaired glucose tolerance and in nonobese Japanese patients with type 2 diabetes (7-9). Visceral fat accumulation is also associated with serum triglyceride (TG) levels, and the disturbance of TG metabolism precedes the development of insulin resistance in nonobese Japanese type 2 diabetic patients (9,10). However, the relationships of visceral adiposity and TG metabolism with insulin resistance in Japanese MONW subjects with normal glucose tolerance have not been evaluated. To clarify these points, in the present study, we investigated the relationship between visceral fat areas or serum levels of TG and insulin resistance in Japanese MONW subjects wit...

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Remnant-like particle cholesterol, triglycerides, and insulin resistance in nonobese Japanese type 2 diabetic patients.

Cited by 90 publications

References 36 publications

How Should we Screen Overweight and Obese Adolescents for Risk of Type 2 Diabetes in Large Public Health Initiatives?

How Should we Screen Overweight and Obese Adolescents for Risk of Type 2 Diabetes in Large Public Health Initiatives?

Relationship between Insulin Resistance and Effect of Atorvastatin in Non-diabetic Subjects

Increased Visceral Fat and Serum Levels of Triglyceride Are Associated With Insulin Resistance in Japanese Metabolically Obese, Normal Weight Subjects With Normal Glucose Tolerance

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