Insulin Sensitivity Indices Calculated from Basal and OGTT-Induced Insulin, Glucose, and FFA Levels

Belfiore, Francesco; Iannello, Silvia; Volpicelli, Giovanni

doi:10.1006/mgme.1997.2658

Cited by 226 publications

(168 citation statements)

References 22 publications

Supporting

Mentioning

156

Contrasting

Unclassified

Order By: Relevance

“…, where INSp and GLYp are insulin and glucose AUCs, respectively, over 2 h after glucose ingestion, expressed relative to average values from the group of individuals [28].…”

Section: Calculations and Statistical Analysismentioning

confidence: 99%

Markers of de novo lipogenesis in adipose tissue: associations with small adipocytes and insulin sensitivity in humans

et al. 2009

View full text Add to dashboard Cite

Aims/hypothesis Previous studies have shown relationships between fatty acid ratios in adipose tissue triacylglycerol (TG), adipocyte size and measures of insulin sensitivity. We hypothesised that variations in adipose tissue de novo lipogenesis (DNL) in relation to adiposity might explain some of these observations. Methods In a cross-sectional study, subcutaneous abdominal adipose tissue biopsies from 59 people were examined in relation to fasting and post-glucose insulin sensitivity. Adipocyte size, TG fatty acid composition and mRNA expression of lipogenic genes were determined. Results We found strong positive relationships between adipose tissue TG content of the fatty acids myristic acid (14:0) and stearic acid (18:0) with insulin sensitivity (HOMA model) (p<0.01 for each), and inverse relationships with adipocyte size (p<0.01, p<0.05, respectively).

show abstract

“…, where INSp and GLYp are insulin and glucose AUCs, respectively, over 2 h after glucose ingestion, expressed relative to average values from the group of individuals [28].…”

Section: Calculations and Statistical Analysismentioning

confidence: 99%

Markers of de novo lipogenesis in adipose tissue: associations with small adipocytes and insulin sensitivity in humans

et al. 2009

View full text Add to dashboard Cite

show abstract

“…Insulin sensitivity indices for NEFA were estimated using data from fasting and 1 and 2 h samples for insulin and NEFA concentrations, according to the established method proposed for calculating insulin sensitivity from data obtained during an OGTT [21].…”

Section: Measurement Of Insulin Sensitivity In Individual Tissues (Sementioning

confidence: 99%

Cortisol clearance and associations with insulin sensitivity, body fat and fatty liver in middle-aged men

et al. 2007

View full text Add to dashboard Cite

Aims/hypothesis The regulation of cortisol metabolism in vivo is not well understood. We evaluated the relationship between cortisol metabolism and insulin sensitivity, adjusting for total and regional fat content and for non-alcoholic fatty liver disease. Materials and methods Twenty-nine middle-aged healthy men with a wide range of BMI were recruited. We measured fat content by dual-energy X-ray absorptiometry and magnetic resonance imaging (MRI), liver fat by ultrasound and MRI, the hypothalamic-pituitary-adrenal axis by adrenal response to ACTH 1-24 , unconjugated urinary cortisol excretion, corticosteroid-binding globulin, and cortisol clearance by MS. We assessed insulin sensitivity by hyperinsulinaemic-euglycaemic clamp and by OGTT. Results Cortisol clearance was strongly inversely correlated with insulin sensitivity (M value) (r=−0.61, p=0.002). Cortisol clearance was increased in people with fatty liver compared with those without (mean±SD: 243±10 vs 158± 36 ml/min; p = 0.014). Multiple regression modelling showed that the relationship between cortisol clearance and insulin sensitivity was independent of body fat. The relationship between fatty liver and insulin sensitivity was significantly influenced by body fat and cortisol clearance. Conclusions/interpretation Cortisol clearance is strongly associated with insulin sensitivity, independently of the amount of body fat. The relationship between fatty liver and insulin sensitivity is mediated in part by both fatness and cortisol clearance.

show abstract

“…29 With this method, ISI (gly) and ISI (NEFA) are obtained under rather physiological conditions, not under artificially induced steady state as during a euglycaemic clamp. A higher value of ISI gly indicates greater insulin sensitivity.…”

Section: Calculations and Statisticsmentioning

confidence: 99%

Subcutaneous adipose tissue blood flow varies between superior and inferior levels of the anterior abdominal wall

et al. 2003

View full text Add to dashboard Cite

OBJECTIVE: Blood flow regulation is thought to mediate the metabolic functions of adipose tissue. Different depots, and even different layers within the subcutaneous adipose tissue, may vary in metabolic activity and blood flow. Therefore, we investigated if any differences in subcutaneous adipose tissue blood flow (ATBF) exist at different locations of the anterior abdominal wall. METHODS: ATBF was measured 8-10 cm above or below the umbilicus, at 8-10 cm (both sides) from the midline, in 18 healthy subjects (BMI range 18-33 kg/m 2 ). Measurements of ATBF were performed using 133 xenon washout, during a stable baseline period and after ingestion of 75 g of glucose. RESULTS: At baseline, ATBF was greater at the upper level compared to the lower level (4.470.3 vs 3.870.2 ml min À1 100 g tissue À1 , P ¼ 0.005), but was not different between the right and the left sides at either level. ATBF increased in response to oral glucose at all sites. The mean increase at the superior level was also greater than the inferior level (3.570.7 vs 2.270.6 ml min À1 100 g tissue À1 , P ¼ 0.001). CONCLUSIONS: Even at a constant depth and with only 16-20 cm difference between sites, there are significant differences in function of the same adipose depot. These findings have physiological and methodological implications for in vivo metabolic studies of human adipose tissue.

show abstract

Insulin Sensitivity Indices Calculated from Basal and OGTT-Induced Insulin, Glucose, and FFA Levels

Cited by 226 publications

References 22 publications

Markers of de novo lipogenesis in adipose tissue: associations with small adipocytes and insulin sensitivity in humans

Markers of de novo lipogenesis in adipose tissue: associations with small adipocytes and insulin sensitivity in humans

Cortisol clearance and associations with insulin sensitivity, body fat and fatty liver in middle-aged men

Subcutaneous adipose tissue blood flow varies between superior and inferior levels of the anterior abdominal wall

Contact Info

Product

Resources

About