Insulin Sensitivity as a Risk Factor for Common Carotid Intima Media Thickness (IMT): Its Relation to Atherosclerosis

Deo, Sudha S; Mahadik, Sujata R.; Chogle, Arun R; Soneji, Surendra L; Lulla, C.P.

doi:10.1080/10641960701615667

Cited by 5 publications

(1 citation statement)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The latter amplifies dyslipidemia including high levels of low-density lipoprotein cholesterol (LDL-C) and decreased levels of high-density lipoprotein cholesterol (HDL-C) [4]. On the other hand, there is still a controversy concerning the relationship between insulin resistance and atherosclerosis measured by intima media thickness [5].…”

Section: Introductionmentioning

confidence: 99%

Do Obese Patients after Weight Loss Become Metabolically Normal?

et al. 2011

View full text Add to dashboard Cite

Objective: To compare the metabolic cardiovascular risk factors of obese patients after weight loss and 4-year weight loss maintenance afterwards against a matched control group of subjects with a stable body weight and without history of weight loss. Method: 50 obese non-diabetic subjects in the study group who previously lost 10% or more of their weight and afterwards entered a 4-year weight loss maintenance programme were matched by age, BMI and sex and compared to 50 weight-stable subjects without history of weight loss. The comparison between both groups was done in term of anthropometrical, metabolic and biological characteristics, early atherosclerosis and insulin sensitivity. Results: Anthropometrical, metabolic and biological characteristics were similar between the weight loss group and the control matched group. However, insulin sensitivity was still significantly lower in the weight loss than in the matched control group (p = 0.02). Intima media thickness (IMT) also was similar in both groups. We found that lower atherosclerosis measured by IMT at the level of the carotid is associated with better insulin sensitivity (p < 0.05). After the 4-year weight loss maintenance programme, insulin sensitivity improved in the post-weight loss group from 7.9 ( 3.2 to 8.4 ( 3.6 mg/kg/min. Conclusion: All cardiometabolic parameters of obese subjects, except for insulin sensitivity, normalised completely after weight loss. The latter was improved by a weight loss maintenance programme if successfully completed.

show abstract

Section: Introductionmentioning

confidence: 99%