Association between inflammatory cytokines and insulin resistance in Indian hypertensive patients

Mahadik, Sujata R.

doi:10.1016/j.jicc.2013.06.003

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Tumor Cells Can Secrete Il-61

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2021

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“…Previous studies have shown that interleukin 6 (IL-6) is one of the cytokines predictive muscle loss induced by CAC (Bonetto et al, 2012;Kim et al, 2013;Mahadik and Sujata, 2013;Mauer et al, 2014), it can accelerate muscle loss indued by CAC. And tumor cells are an important source of IL-6 (Carson and Baltgalvis, 2010b;Han et al, 2018;Pettersen et al, 2017).…”

Section: Tumor Cells Can Secrete Il-6mentioning

confidence: 99%

MMP12 Knockout Prevent Weight and Muscle Loss Induced by Cancer Cachexia

Jiang

Yang

et al. 2021

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Weight loss and muscle wasting can have devastating impacts on survival and quality of life of patients with cancer cachexia. Here, we have established a hybrid mouse of ApcMin/+ mice and MMP12 knockout mice (ApcMin/+; MMP12-/-) and found that knockout MMP12 can suppress the weight and muscle loss of ApcMin/+ mice. In detail, we found that interleukin 6 was highly upregulated in the serum of cancer patients and MMP12 was increased in muscle of tumor-bearing mice. Interestingly, the interleukin 6 secreted by tumor cells led to MMP12 overexpression in the macrophages, which further resulted in degradation of insulin and insulin-like growth factor 1 and interruption of glycolipid metabolism. Notably, depletion of MMP12 prevented weight loss of ApcMin/+ mice. Our study uncovers the critical role of MMP12 in controlling weight and highlights the great potential of MMP12 in the treatment of cancer cachexia.

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