Insulin secretion in children with constitutional familial short stature

Karp, M; Laron, Zvi; Doron, M.

doi:10.1016/s0022-3476(73)80483-4

Cited by 17 publications

(14 citation statements)

References 7 publications

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“…Similarly, in the present study, the mean plasma IRI response to arginine in the six adolescent females with anorexia nervosa was significantly less than in the normal group. Also, in agreement with several reports (22,25,27), the group of children with idiopathic short stature had decreased plasma IRI levels, both before and after arginine, although the differences from normal were not significant.…”

Section: Plasma Immunoreactive Insulin (Iri) (supporting

confidence: 93%

Plasma Growth Hormone, Insulin, and Glucagon Responses to Arginine Infusion in Children and Adolescents with Idiopathic Short Stature, Isolated Growth Hormone Deficiency, Panhypopituitarism, and Anorexia Nervosa

et al. 1975

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ExtractThe effects of intravenous infusion of arginine (20 g/m2) after an overnight fast on plasma immunoreactive growth hormone (GH), insulin (IRI), and glucagon (IRG), and blood glucose were examined in five groups of children and adolescents: 10 normal individuals, 18 with idiopathic short stature, 6 with isolated growth hormone deficiency, 8 with panhypopituitarism, and 6 with anorexia nervosa.The mean fasting plasma GH concentration was significantly elevated in the group with anorexia nervosa (P < 0.05), and similar to the value for the normal group in all other groups. After arginine infusion, four-to sixfold increases of plasma G H were observed in the normal children, and similar increases were seen in those with idiopathic short stature as well as in those with anorexia nervosa; whereas, in the children with isolated growth hormone deficiency or panhypopituitarism, there was no significant increase in plasma GH. Fasting blood glucose concentrations were significantly lower than normal in subjects with isolated growth hormone deficiency ( P < 0.05), panhypopituitarism ( P < 0.001), and anorexia nervosa (P < 0.001), whereas fasting plasma IRI and IRG concentrations were similar to the values in the normal group. Plasma IRI increased eightfold at the end of the 30-min arginine infusion in the normal subjects; the increase was slightly but not significantly less in those with idiopathic short stature, and significantly less in those with isolated growth hormone deficiency ( P < 0.05), panhypopituitarism ( P < 0.001), and anorexia nervosa ( P < 0.05). Arginine infusion resulted in two-to threefold increases of plasma IRG in the normal group, and similar increases were observed in all of the other groups tested. These results suggest that whereas pancreatic P cell responsiveness may be deficient in children and adolescents with isolated growth hormone deficiency, panhypopituitarism, or anorexia nervosa, pancreatic a cell responsiveness, to arginine a t least, appears to be intact under these conditions. SpeculationAlthough plasma glucagon responses to arginine infusion were not less in subjects with hypopituitarism or anorexia nervosa than in normal subjects, relative hypoglucagonemia may have existed, since both basal and postarginine infusion plasma glucagon levels were not higher than normal in the presence of significantly lower blood glucose values. Thus, the present study does not exclude a deficient pancreatic a cell response to hypoglycemia. Alternatively, nonavailability of substrates for gluconeogenesis may have a more important influence than hormonal factors in the genesis of the hypoglycenia observed in these states.73

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Section: Plasma Immunoreactive Insulin (Iri) (supporting

confidence: 93%

Plasma Growth Hormone, Insulin, and Glucagon Responses to Arginine Infusion in Children and Adolescents with Idiopathic Short Stature, Isolated Growth Hormone Deficiency, Panhypopituitarism, and Anorexia Nervosa

et al. 1975

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“…Weight gain follows the same trend as growth in height [205,206,296]. Particular leanness as claimed by Karp et al [128,129] has not been observed by other investigators [24,197]. In children with pure CDGAD bone age is delayed to the same extent as height age.…”

Section: Clinical Aspectsmentioning

confidence: 90%

“…The results published by five large centres give the data of a total of 94 patients with CDGAD [22,92,127,128,233,317]. The increments of plasma-GH corresponded to the values seen in healthy children.…”

Section: Growth Hormonementioning

confidence: 98%

“…Depending on whether primarily the disturbed growth or the delayed adolescence is considered, the following synonyms have been used: essential growth retardation, simple delay of growth [197], constitutional familial short stature [128,141], constitutional shortness of stature [63,127] or constitutional delayed adolescence [116], and constitutional late maturity. In the German speaking countries generally the term "konstitutionelle Entwicklungsverz~Sgerung" (constitutional delay of development) is used.…”

Section: Nomenclaturementioning

confidence: 99%

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Stunted growth with more or less normal appearance

et al. 1982

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“…Karp et al (1) found a similar poor insulin response to arginine infusion and to oral glucose stimulation in patients with familial short stature.…”

mentioning

confidence: 89%

Abnormalities in Growth Hormone and Insulin Release in Short but Otherwise Normal Patients

Raiti¹,

Maclaren²,

Trías³

et al. 1977

Horm Res

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Arginine-insulin stimulation and IV glucose suppression (AIGT) tests were used to evaluate release of insulin and growth hormone. Adult patients responded normally. Hypopituitary patients showed no hGH response. One third of short normal patients showed abnormal hGH responses to glucose suppression. Two thirds of the short normal patients showed poor insulin responses to either amino acid or glucose stimulation. Such patients might have abnormalities in release mechanisms for insulin and suppression mechanisms for hGH and this might contribute to their growth failure.

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Insulin secretion in children with constitutional familial short stature

Cited by 17 publications

References 7 publications

Plasma Growth Hormone, Insulin, and Glucagon Responses to Arginine Infusion in Children and Adolescents with Idiopathic Short Stature, Isolated Growth Hormone Deficiency, Panhypopituitarism, and Anorexia Nervosa

Plasma Growth Hormone, Insulin, and Glucagon Responses to Arginine Infusion in Children and Adolescents with Idiopathic Short Stature, Isolated Growth Hormone Deficiency, Panhypopituitarism, and Anorexia Nervosa

Stunted growth with more or less normal appearance

Abnormalities in Growth Hormone and Insulin Release in Short but Otherwise Normal Patients

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