We suggest that early initiation of combined therapy comprising a high dose of metformin plus rosiglitazone may be valuable in managing insulin resistance and DM2 in children with AS.
Arginine-insulin stimulation and IV glucose suppression (AIGT) tests were used to evaluate release of insulin and growth hormone. Adult patients responded normally. Hypopituitary patients showed no hGH response. One third of short normal patients showed abnormal hGH responses to glucose suppression. Two thirds of the short normal patients showed poor insulin responses to either amino acid or glucose stimulation. Such patients might have abnormalities in release mechanisms for insulin and suppression mechanisms for hGH and this might contribute to their growth failure.
Muscle C m n i t i n e Deficiency i n a P a t i e n t with 877 1 P e r s i s t e n t Neonatal Diabetes and Hypokalemia. A 3 year old Cuban female with p e r s i s t e n t neonatal diabetes m e l l i t u s developed corneal o p a c i t i e s , photophobia, hirsuitism and f a i l u r e t o t h r i v e following a prolonged episode of hypoglycemia with coma and s e i z u r e a t 8 months of age. Generalized myopathy with marked proximal muscle weakness was noted a t 2 years of age. P e r s i s t e n t hypokalemia was noted from % years of
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