Insulin secretion and sensitivity in non-obese and obese Japanese patients with coronary artery disease

Kanauchi, Masao; Motomiya, Kotomi; Hashimoto, Takeji

doi:10.1053/meta.2002.29985

Cited by 8 publications

(10 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This also indicated that a decrease in beta cell function can be detected as fasting glucose increases, even in patients with normal glucose tolerance. This was a similar conclusion to Kristina M.'s study 20) . Decreased beta cell function can also be used to identify individuals at increased risk for type 2 diabetes.…”

Section: Discussionsupporting

confidence: 91%

“…R.A. DeFronzo et al demonstrated for the first time that individuals with angiographically documented CAD are characterized by insulin resistance 16) . It is well known that insulin resistance is directly related to the occurrence of atherosclerosis and the risk for cardiovascular diseases [17][18][19] ; however, few studies have focused on the relationship between insulin secretion and coronary atherosclerosis 3,4,20) . Moreover, these studies did not investigate beta cell function together with insulin secretion.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Decreased Beta Cell Function and Insulin Sensitivity Contributed to Coronary Artery Disease in Patients with Normal Glucose Tolerance

Wang

Feng

2012

JAT

View full text Add to dashboard Cite

Aim:To investigate the association among insulin sensitivity, insulin secretion, beta cell function and coronary artery disease (CAD) in patients with normal glucose tolerance. Methods: One hundred eighty-nine patients with normal glucose tolerance (NGT) participated in this study and underwent coronary angiography. We estimated the severity of CAD by counting the number of diseased vessels and Gensini score using coronary angiography. The HOMA-IR index and Matsuda index were used to estimate insulin sensitivity. Insulin secretion was assessed using the HOMA-β index, insulinogenic index and AUC-insulin/glucose. Beta cell function was assessed using the basal disposition index, early-phase disposition index and total disposition index. We finally determined the relationship between CAD and these indices. Results: There were statistically significant differences in the HOMA-IR, Matsuda index, basal disposition index, early-phase disposition index and total disposition index both in the single-and multiple-diseased vessel groups when compared to the 0-diseased vessel group; however, there was no significant difference between the single-and multiple-diseased vessel groups. Moreover, HOMA-β, the insulinogenic index and AUC-ins/glu showed no significant difference among the three groups. Multivariate logistic regression analysis suggested that the HOMA-IR, Matsuda index, early-phase disposition index and total disposition index were independent risk factors for the presence of CAD. Conclusion: Insulin resistance and beta cell function were closely related to the incidence of CAD in patients with normal glucose tolerance. J Atheroscler Thromb, 2012; 19:806-813.

show abstract

Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Decreased Beta Cell Function and Insulin Sensitivity Contributed to Coronary Artery Disease in Patients with Normal Glucose Tolerance

Wang

Feng

2012

JAT

View full text Add to dashboard Cite

show abstract

“…Possible contributions of these two factors have been shown to be ethnicity dependent to some extent (2,3). In the Caucasian population, a decreased insulin sensitivity is a primary metabolic defect underlying glucose intolerance, whereas an impaired insulin secretion mainly accounts for glucose intolerance in the Japanese population, among other Asian populations (4,5). As a consequence, Caucasian diabetic patients are often accompanied by obesity and increased fasting glucose concentrations, whereas Japanese counterparts are relatively lean and having normal fasting glucose levels but increased postprandial hyperglycemia.…”

mentioning

confidence: 99%

Glucose Intolerance Is Common in Japanese Patients With Acute Coronary Syndrome Who Were Not Previously Diagnosed With Diabetes

Hashimoto¹,

Ikewaki

Yagi

et al. 2005

Diabetes Care

View full text Add to dashboard Cite

OBJECTIVE -Postprandial hyperglycemia has emerged as a new glycometabolic condition associated with an excessive risk for coronary artery disease. We therefore attempted to evaluate the frequency of postchallenge hyperglycemia in patients with acute coronary syndrome (ACS) who were not previously diagnosed to have diabetes and did not have a fasting glucose concentration of Ն7 mmol/l or an HbA 1c level Ͼ6.0%. We further correlated the presence of postchallenge hyperglycemia with the extent of coronary atherosclerosis. RESEARCH DESIGN AND METHODS-In all, 134 consecutive ACS patients who met the above inclusion criteria were studied. An oral glucose tolerance test was performed before discharge.RESULTS -The mean age, fasting glucose, and HbA 1c were 60 years, 5.15 mmol/l, and 5.4%, respectively. Among ACS patients, impaired glucose tolerance (IGT) and diabetes were found in 50 (37%) and 13 patients (10%), respectively. The homeostasis model assessment for insulin resistance did not differ substantially among the normal glucose tolerance (NGT), IGT, and diabetic groups. Insulinogenic index, however, was lower and the number of stenosed vessels higher in diabetic patients compared with NGT patients.CONCLUSIONS -Postchallenge hyperglycemia, caused primarily by impaired initial insulin secretion, is commonly found in Japanese ACS patients who have not been previously diagnosed with diabetes, and this phenomenon is considered to be associated with advanced coronary atherosclerosis. Therefore, the present study strongly supports the notion that oral glucose tolerance test assessment of postchallenge hyperglycemia is essential to identify any previously undiagnosed diabetes cases among Japanese ACS patients. Diabetes Care 28:1182-1186, 2005T he number of diabetic patients in Japan is now estimated to be Ͼ6.8 million (1). Furthermore, the number of diabetic patients in Japan and other southeastern Asian countries is expected to increase at the fastest rate worldwide. This trend, together with its associated complications that involve a substantial utilization of resources, make diabetes an extremely important health problem in Japan.Impaired insulin secretion or/and impaired insulin sensitivity play a pivotal role in the development of type 2 diabetes. Possible contributions of these two factors have been shown to be ethnicity dependent to some extent (2,3). In the Caucasian population, a decreased insulin sensitivity is a primary metabolic defect underlying glucose intolerance, whereas an impaired insulin secretion mainly accounts for glucose intolerance in the Japanese population, among other Asian populations (4,5). As a consequence, Caucasian diabetic patients are often accompanied by obesity and increased fasting glucose concentrations, whereas Japanese counterparts are relatively lean and having normal fasting glucose levels but increased postprandial hyperglycemia.An increased prevalence of glucose intolerance has been previously reported in patients with acute coronary syndrome (ACS) in a European population (6). ...

show abstract

“…Glucose intolerance can thus be concluded to be predominantly attributed to impaired initial insulin secretion rather than insulin resistance, as previously found in the recent reports of Japanese patients with type 2 diabetes 43 and with CHD. 34,44 Though the high prevalence of sd-LDL could not be conclusively associated with insulin resistance, it was certainly more strongly associated with impaired postprandial glucose regulation rather than with fasting glucose levels in the non-DM ACS patients.…”

Section: Discussionmentioning

confidence: 99%

Predominance of Small Dense Low-Density Lipoproteins and Abnormal Glucose Regulation in Patients With Acute Coronary Syndrome

Ban

Koba

Tsunoda

et al. 2006

Circ J

View full text Add to dashboard Cite

Insulin secretion and sensitivity in non-obese and obese Japanese patients with coronary artery disease

Cited by 8 publications

References 17 publications

Decreased Beta Cell Function and Insulin Sensitivity Contributed to Coronary Artery Disease in Patients with Normal Glucose Tolerance

Decreased Beta Cell Function and Insulin Sensitivity Contributed to Coronary Artery Disease in Patients with Normal Glucose Tolerance

Glucose Intolerance Is Common in Japanese Patients With Acute Coronary Syndrome Who Were Not Previously Diagnosed With Diabetes

Predominance of Small Dense Low-Density Lipoproteins and Abnormal Glucose Regulation in Patients With Acute Coronary Syndrome

Contact Info

Product

Resources

About