2002
DOI: 10.1053/meta.2002.29985
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Insulin secretion and sensitivity in non-obese and obese Japanese patients with coronary artery disease

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Cited by 8 publications
(10 citation statements)
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“…This also indicated that a decrease in beta cell function can be detected as fasting glucose increases, even in patients with normal glucose tolerance. This was a similar conclusion to Kristina M.'s study 20) . Decreased beta cell function can also be used to identify individuals at increased risk for type 2 diabetes.…”
Section: Discussionsupporting
confidence: 91%
See 1 more Smart Citation
“…This also indicated that a decrease in beta cell function can be detected as fasting glucose increases, even in patients with normal glucose tolerance. This was a similar conclusion to Kristina M.'s study 20) . Decreased beta cell function can also be used to identify individuals at increased risk for type 2 diabetes.…”
Section: Discussionsupporting
confidence: 91%
“…R.A. DeFronzo et al demonstrated for the first time that individuals with angiographically documented CAD are characterized by insulin resistance 16) . It is well known that insulin resistance is directly related to the occurrence of atherosclerosis and the risk for cardiovascular diseases [17][18][19] ; however, few studies have focused on the relationship between insulin secretion and coronary atherosclerosis 3,4,20) . Moreover, these studies did not investigate beta cell function together with insulin secretion.…”
Section: Discussionmentioning
confidence: 99%
“…Possible contributions of these two factors have been shown to be ethnicity dependent to some extent (2,3). In the Caucasian population, a decreased insulin sensitivity is a primary metabolic defect underlying glucose intolerance, whereas an impaired insulin secretion mainly accounts for glucose intolerance in the Japanese population, among other Asian populations (4,5). As a consequence, Caucasian diabetic patients are often accompanied by obesity and increased fasting glucose concentrations, whereas Japanese counterparts are relatively lean and having normal fasting glucose levels but increased postprandial hyperglycemia.…”
mentioning
confidence: 99%
“…Glucose intolerance can thus be concluded to be predominantly attributed to impaired initial insulin secretion rather than insulin resistance, as previously found in the recent reports of Japanese patients with type 2 diabetes 43 and with CHD. 34,44 Though the high prevalence of sd-LDL could not be conclusively associated with insulin resistance, it was certainly more strongly associated with impaired postprandial glucose regulation rather than with fasting glucose levels in the non-DM ACS patients.…”
Section: Discussionmentioning
confidence: 99%