Insulin resistance quantified by the value of HOMA‑IR and cardiovascular risk in patients with type 2 diabetes

Abstract

Cardiovascular disease (CVD) is recognized as a leading cause of death worldwide. Obesity, dyslipidemia, insulin resistance (IR), interconnected pathological conditions constitute risk factors that are closely associated with CVD. The aim of the present study was to highlight the association of IR with cardiovascular risk (CVR). The epidemiological, cross-sectional, non-interventional study was conducted over 12 months (2019-2020) within a research grant and included a sample of 400 subjects divided into 2 subgroups: group 1 (control) subjects did not have diabetes (n=200) and group 2 had type 2 diabetes (T2DM) (n=200). The Framingham risk score (FRS) was calculated according to the 2008 general CVD risk model from the Framingham Heart Study. Subsequent to a correlation of the value of homeostasis model assessment of insulin resistance (HOMA-IR) with the degree of CVR, the IR was higher in both groups, and CVR also increased. After being quantified by the Spearman correlation coefficient, the correlation in group 2 was higher at 0.625 compared to group 1 where this coefficient had a value of 0.440. A high FRS (FRS of 20%) was significantly associated with IR. The results therefore show that HOMA-IR is an independent risk factor for high FRS. New therapies focused on decreasing IR may contribute to decreased CVD.

A Study of Biomarkers Associated with Metabolic Dysfunction-Associated Fatty Liver Disease in Patients with Type 2 Diabetes

“…In light of these observations, the results we obtained are very important for the future study of MAFLD in patients with T2DM, opening the perspective for anatomopathological studies that could assess the relationship between the biomarkers predictive of MAFLD and the severity and the progression of the liver disease. Furthermore, as it is the case for AIP, HOMA-IR is also a predictor of cardiovascular risk in patients with T2DM [ 65 ]. Therefore, future studies are necessary to establish the role of this biomarker in predicting the association of cardiovascular disorders with MAFLD in subjects with T2DM.…”

Associations of Chronic Diabetes Complications and Cardiovascular Risk with the Risk of Obstructive Sleep Apnea in Patients with Type 2 Diabetes

“…However, one of these studies concluded that insulin resistance assessed by HOMA-IR, was not associated with AHI but rather with BMI [ 40 ]. A recent study which enrolled patients with T2DM demonstrated that higher HOMA-IR values are associated with increased cardiovascular risk [ 41 ]. In our study, we also observed that HOMA-IR was statistically significantly higher in patients with T2DM and OSA, diagnosed by STOP-Bang score ≥5, thus confirming the results reported in previous studies [ 37 , 38 , 39 ].…”

Association between experience of insulin resistance and long-term cardiovascular disease risk: Findings from the Korean Genome and Epidemiology Study (KOGES)

“…In a recent study by Vladu et al, a higher Framingham Risk Score was signi cantly associated with IR, measured as the homeostasis model assessment of IR (HOMA-IR), in patients with and without diabetes [7]. Similarly, several studies have demonstrated that IR is an independent risk factor for CVD in the general population of both apparently healthy individuals and those with diabetes, regardless of other risk factors [5,[8][9][10][11].…”