A Study of Biomarkers Associated with Metabolic Dysfunction-Associated Fatty Liver Disease in Patients with Type 2 Diabetes

Efrem, Ion Cristian; Moța, Maria; Vladu, Ionela Mihaela; Mitrea, Adina; Clenciu, Diana; Timofticiuc, Diana Cristina Protasiewicz; Diaconu, Ileana-Diana; Turcu, Adina Andreea; Crişan, Anda; Geormăneanu, Cristiana; Glodeanu, Adina Dorina; Mahler, Beatrice; Tudor, Marinela Sinziana; Amzolini, Anca Maria; Alhija, Anca Barău Abu; Mita, Adrian; Filip, Maria Monalisa; Forţofoiu, Maria

doi:10.3390/diagnostics12102426

Cited by 6 publications

(4 citation statements)

References 62 publications

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“…Hence, many studies have focused on finding ever more accurate, minimum-invasive, and economically efficient biomarkers to highlight cardio-metabolic risk signatures in both MAFLD and non-MAFLD overweight and obese patients. Such cardiometabolic surrogate markers validated in both the adult and pediatric populations are the those of the body-fat distribution indices (BMI, TMI, VAI) [ 20 , 21 ] and lipid-derived indices (VAI, AIP, TG/HDL ratio) [ 22 , 23 ].…”

Section: Discussionmentioning

confidence: 99%

Exploring the Role of Serum Osteonectin and Hsp27 in Pediatric MAFLD Diagnosis and Cardiometabolic Health

Bălănescu,

Codreanu

et al. 2024

Nutrients

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Background: Childhood obesity is one of the major challenges of public health policies. The problem of fatty liver in childhood, known as MAFLD (metabolic dysfunction-associated fatty liver disease), is of particular interest as the gold standard diagnosis technique is invasive (liver biopsy). Hence, efforts are made to discover more specific biomarkers for the MAFLD signature. Therefore, the aim of the study was to evaluate Osteonectin and Hsp27 as biomarkers for MAFLD diagnosis and to assess their links with auxological and biochemical profiles of overweight and obese pediatric subjects. Methods: A cross-sectional study in which we (re)analyzed data from the MR PONy cohort comprising 71 pediatric subjects. Auxological data, liver ultrasonography and biochemical serum profile were recorded. Lipid-derived indices and body composition indices were calculated. Nevertheless, serum Osteonectin and Hsp27 levels were assessed using an ELISA approach. Results: MAFLD prevalence was 40.8%. Higher Osteonectin levels were noted in MAFLD subjects versus non-MAFLD subjects and in dyslipidemic children regardless of their liver function status. Lipid-derived indices had good diagnostic capacity for MAFLD. Conclusions: We confirm Osteonectin as a MAFLD diagnosis biomarker in children. Also, lipid-derived indices are useful as metabolic-associated organ impairment markers in children even before the onset of obesity.

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Section: Discussionmentioning

confidence: 99%

Exploring the Role of Serum Osteonectin and Hsp27 in Pediatric MAFLD Diagnosis and Cardiometabolic Health

Bălănescu,

Codreanu

et al. 2024

Nutrients

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“…The triglyceride-glucose (TyG) index is currently considered as a novel and reliable indicator of insulin resistance (IR) in recent studies [10] . Its elevation is associated with several diseases such as atherosclerosis, coronary artery stenosis, and erectile dysfunction [11] . IR may reduce urinary pH and lead to defects in renal citrate excretion, which may increase the risk of kidney stone formation.…”

Section: Introductionmentioning

confidence: 99%

Clinical Lipid Metabolism Correlates with Urinary Calculus: TyG Index Has a Closer Correlation

Pan

Zhang

et al. 2023

Preprint

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Aims:We aimed to assess the association between lipid metabolism and kidney stones in Chinese adults. Methods:Data were obtained from the clinical data of our center in the past 3 years. The analysis included complete data on blood lipids and kidney stones in participants aged ≥18 years and non-stone controls. Weighted multivariate regression analysis and subgroup analysis were used to estimate the relationship between various lipid indexes and nephrolithiasis and burden and recurrence. Results: A total of 414 participants were included in the study, and their gender, age and other basic indicators showed no significant differences. In the adjusted logistic regression analysis results, the prevalence of kidney stones increased with the increase of triglyceride (TG), triglyceride-glucose (TyG) index and Apolipoprotein A-I (AIP) [TG: odds ratio (OR)= 2.14; 95% CI: 1.62-2.81; p < 0.001; TyG: OR=4.30; 95% CI: 2.75-6.72; p < 0.001; AIP: OR=10.12; 95% CI: 4.58-22.35; p < 0.001]. There was still a significant correlation with TyG index in the subgroup analysis of burden (OR=1.52; 95% CI: 1.04-2.22; p < 0.05) and recurrence (OR=2.77; 95% CI: 1.08-7.13; p < 0.05). Conclusions:Lipid metabolism is closely related to urinary system stones, and a higher TyG index is associated with an increased risk of kidney stone incidence, burden, and recurrence. We hypothesize that timely treatment and management of abnormal lipid metabolism may help improve or alleviate the occurrence, burden, and recurrence of urinary system stones. However, further large-scale prospective studies and basic experiments are still needed to clarify the exact causal relationship of this association.

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“…This was been the primary known effect until recently. However, in recent decades, an increasing number of studies have focused on the effects of vitamin D, both in the inflammatory response at the intestinal level [10,11] and in sarcopenia [12][13][14]. At the skin level, there is a correlation between vitamin D and the fortification of skin structure, as vitamin D stimulates the secretion of collagen [15].…”

Section: Introductionmentioning

confidence: 99%

The Indirect Effects of Vitamin D3 on the Aging Process According to Gender

Ghitea¹

2023

Preprint

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Background/Aim: Rapid onset of facial ptosis can impact physical appearance and compromise the outcomes of facelift procedures. The level of vitamin D has a potential correlation with collagen formation and its deficiency with inflammatory processes that affect the breakdown of hyaluronic acid. This study aims to investigate the potential relationship between accentuated facial ptosis in women and low levels of vitamin D. Furthermore, it aims to explore preventive measures or strategies to slow down facial ptosis and enhance the longevity of facelift results. Materials and Methods: The study was focused on monitoring the vitamin D levels in women and men with advanced facial ptosis and comparing them with a control group. Results: Notably, a direct association between gender and serum vitamin D levels was observed, indicating less sustainable outcomes in women. Conclusion: Women face additional challenges in the aging process due to hormonal shifts after menopause or premenopausal, which are associated with osteoporosis and lower vitamin D levels.

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A Study of Biomarkers Associated with Metabolic Dysfunction-Associated Fatty Liver Disease in Patients with Type 2 Diabetes

Cited by 6 publications

References 62 publications

Exploring the Role of Serum Osteonectin and Hsp27 in Pediatric MAFLD Diagnosis and Cardiometabolic Health

Exploring the Role of Serum Osteonectin and Hsp27 in Pediatric MAFLD Diagnosis and Cardiometabolic Health

Clinical Lipid Metabolism Correlates with Urinary Calculus: TyG Index Has a Closer Correlation

The Indirect Effects of Vitamin D3 on the Aging Process According to Gender

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