Insulin resistance, its consequences for the clinical course of the disease, and possibilities of correction in endometrial cancer

Berstein, Lev M.; Kvatchevskaya, J. O.; Порошина, Т. Е.; Коваленко, И. Г.; Цырлина, Е. В.; Zimarina, T. S.; Ourmantcheeva, A. F.; Ашрафян, Л. А.; Thijssen, J. H. H.

doi:10.1007/s00432-004-0587-2

Cited by 64 publications

(49 citation statements)

References 32 publications

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“…Hyperinsulinemia may increase levels of free estrogen through decreasing concentrations of circulating sex hormone-binding globulin (41,42), and several epidemiologic studies have observed an increased risk of endometrial cancer in relation to high prediagnostic C-peptide indicating hyperinsulinemia (43). It has also been suggested that hyperinsulinemia and insulin resistance are associated with a more aggressive course of endometrial cancer (44). Furthermore, hyperinsulinemia through decreasing levels of insulin-like growth factor-binding protein-3 increases circulating free insulin-like growth factor-I, which, by binding and activating insulin-like growth factor-I receptors in the endometrium, stimulates cell proliferation (45)(46)(47)(48)(49).…”

Section: Discussionmentioning

confidence: 99%

Physical Activity and Risk of Endometrial Cancer: A Population-Based Prospective Cohort Study

Friberg

Mantzoros

Wolk

2006

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Physical activity is involved in the regulation of metabolic and hormonal pathways and is one of the factors important for the maintenance of body weight; obesity is a risk factor for endometrial cancer. A connection between physical activity and endometrial cancer risk through hormonal mechanisms, possibly mediated by body weight, is biologically plausible. Only one study has investigated total physical activity, and no previous study has examined leisure time inactivity directly. We investigated the association of total physical activity and different types of physical activity with risk of endometrial cancer in the Swedish Mammography Cohort, a population-based prospective cohort, including 33,723 women and 199 endometrial cancer cases. After adjustments for potential confounders (age, body mass index, parity, history of diabetes, total fruit and vegetable intake, and education), the relative risks for endometrial cancer for the second to fourth quartile of total physical activity compared with the lowest one were 0.80 [95% confidence interval (95% CI), 0.54-1.18], 0.87 (95% CI, 0.59-1.28), and 0.79 (95% CI, 0.53-1.17). High leisure time inactivity (watching TV/sitting z5 hours daily) compared with low was associated with increased risk of endometrial cancer (relative risk, 1.66; 95% CI, 1.05-2.61). The associations were not modified by body mass index. Findings from this study suggest that total physical activity is weakly inversely associated with endometrial cancer risk and that leisure time inactivity is statistically significantly associated with increased risk for endometrial cancer. (Cancer Epidemiol Biomarkers Prev 2006;15(11):2136 -40)

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Section: Discussionmentioning

confidence: 99%

Physical Activity and Risk of Endometrial Cancer: A Population-Based Prospective Cohort Study

Friberg

Mantzoros

Wolk

2006

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…Berstein et al examined the prevalence of insulin resistance in a cohort of women with endometrial cancer, excluding those with a clinical diagnosis of diabetes. 21 In their study, insulin resistance was calculated using preoperative fasting insulin and glucose levels. 22 They reported that 35% of their cohort was insulin-resistant.…”

Section: Discussionmentioning

confidence: 99%

Association between adiponectin, insulin resistance, and endometrial cancer

Soliman

Tortolero‐Luna

et al. 2006

Cancer

208

170

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This paper presents an integrated system designed to obtain a high‐resolution image via super‐resolution image reconstruction by using an observer of a motorized head under control. An advantage of this integration is that the constructed system can algebraically and systematically calculate the registration and motion blur identification, which is quite different from the way in which the conventional methods preprocess captured images. To illustrate the effectiveness of the presented system, some experimental results are provided. © 2013 Institute of Electrical Engineers of Japan. Published by John Wiley & Sons, Inc.

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“…In addition, obesity, excess estrogen, type II diabetes, and hypertension are important risk factors for endometrial carcinoma [77,78], but the effects of PPARγ agonists on endometrial carcinoma are largely unknown. Very recently, we examined the expression of PPARγ mRNA and protein in normal endometria and its disorders [79].…”

Section: ) Peroxisome Proliferator-activated Receptor (Ppar) Ligandmentioning

confidence: 99%

Biological Roles of Estrogen and Progesterone in Human Endometrial Carcinoma - New developments in potential endocrine therapy for endometrial cancer -

et al. 2007

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Abstract. Endometrial carcinoma is one of the most common female pelvic malignancies. It is well known that uterine endometrial cell proliferation is under the control of both estrogen and progesterone. In this review, results of the recent studies on the biosynthesis and action of estrogen and progestin in normal endometrium and its disorders will be summarized and the new aspects of hormonal therapies in the patients with endometrial carcinoma will be discussed including its future prospectives. We reported that the enzymes responsible for intratumoral estrogen metabolism and biosynthesis are markedly different between human breast and endometrial carcinoma, although both of them are considered "estrogen-dependent malignancies". In addition, the biological significance of Progesterone receptor (PR) isoforms is considered to differ between endometrial and breast carcinomas. Clinical data concerning Hormone replacement therapy (HRT) and estrogen-dependent cancer risk also support these findings. These basic and clinical findings help to understand the biology and provide the new knowledge for prevention, diagnosis and treatment of human endomerial carcinoma. Specific endocrine treatment of endometrial carcinoma should be explored in future, although aromatase inhibitors are the most effective endocrine treatments of estrogen-responsive breast carcinoma. Retinoid, metabolities of vitamin A, and synthetic peroxisome proliferator-activated receptor (PPAR) γ ligands, which have been used for the treatment of insulin resistance in type II diabetes mellitus, may be the important candidates as drugs not only for prevention but also for possible endocrine treatment of endometrial carcinoma.

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Insulin resistance, its consequences for the clinical course of the disease, and possibilities of correction in endometrial cancer

Cited by 64 publications

References 32 publications

Physical Activity and Risk of Endometrial Cancer: A Population-Based Prospective Cohort Study

Physical Activity and Risk of Endometrial Cancer: A Population-Based Prospective Cohort Study

Association between adiponectin, insulin resistance, and endometrial cancer

Biological Roles of Estrogen and Progesterone in Human Endometrial Carcinoma - New developments in potential endocrine therapy for endometrial cancer -

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