Insulin resistance increases the risk of urinary stone formation in a rat model of metabolic syndrome

Iba, Akinori; Kohjimoto, Yasuo; Mori, Takashi; Kuramoto, Tomomi; Nishizawa, Satoshi; Fujii, Reona; Nanpo, Yoshihito; Matsumura, Nagahide; Shintani, Yasuyo; Inagaki, Takeshi; Hara, Isao

doi:10.1111/j.1464-410x.2010.09216.x

Cited by 35 publications

(31 citation statements)

References 23 publications

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“…Previous studies have established the association between UC and metabolic syndrome (MS), which is characterized by a cluster of features including dyslipidemia, hyperglycemia, hypertension, obesity, and insulin resistance [16]. Such symptoms have been demonstrated in a rat model of metabolic syndrome to precipitate changes in urinary constituents and to lead to an increased risk of uric acid and calcium stone formation [17]. One prospective longitudinal study in humans has demonstrated that uric acid stone formers have a significantly higher prevalence of diabetes and glucose intolerance, and an elevated serum triglyceride concentration compared to normal controls [18].…”

Section: Discussionmentioning

confidence: 99%

Association between Prostate Cancer and Urinary Calculi: A Population-Based Study

2013

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BackgroundUnderstanding the reasons underlying the emerging trend and the changing demographics of Asian prostate cancer (PC) has become an important field of study. This study set out to explore the possibility that urinary calculi (UC) and PC may share an association by conducting a case-control study on a population-based database in Taiwan.MethodsThe cases of this study included 2,900 subjects ≥ 40 years-old who had received their first-time diagnosis of PC and 14,500 randomly selected controls without PC. Conditional logistic regressions were employed to explore the association between PC and having been previously diagnosed with UC.ResultsWe found that prior UC was found among 608 (21.0%) cases and 2,037 (14.1%) controls (p<0.001). Conditional logistic regression analysis revealed that compared to controls, the odds ratio (OR) of prior UC for cases was 1.63 (95% CI = 1.47–1.80). Furthermore, we found that cases were more likely to have been previously diagnosed with kidney calculus (OR = 1.71; 95% CI = 1.42–2.05), bladder calculus (OR = 2.06; 95% CI = 1.32–3.23), unspecified calculus (OR = 1.66; 95% CI = 1.37–2.00), and ≥2 locations of UC (OR = 1.73; 1.47–2.02) than controls. However, there was no significant relationship between PC and prior ureter calculus. We also found that of the patients with UC, there was no significant difference between PC and treatment method.ConclusionsThis investigation detected an association between PC and prior UC. These results highlight a potential target population for PC screening.

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Section: Discussionmentioning

confidence: 99%

Association between Prostate Cancer and Urinary Calculi: A Population-Based Study

2013

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“…In another study, Tsujihata et al 41 showed a decrease in renal crystal retention in rats with atorvastatin. In a study carried out on rats, Iba et al 42 indicated that elevated TG levels resulted in elevated urinary uric acid and calcium excretion, and this ultimately led to renal stone formation. Garbachinsky et al 9 suggested MetS associated with lipotoxicity-lipid accumulation in the kidney-causing changed renal structure and function.…”

Section: Discussionmentioning

confidence: 99%

Association between Body Mass Index, Lipid Profiles, and Types of Urinary Stones

et al. 2012

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“…Previous studies have established the association between nephrolithiasis and metabolic syndrome, which is characterised by a cluster of features including dyslipidaemia, hyperglycaemia, hypertension, obesity, and insulin resistance [ 19 ] . Such symptoms have been shown in a rat model of metabolic syndrome to precipitate changes in urinary constituents and to lead to an increased risk of uric acid and calcium stone formation [ 20 ] . One prospective longitudinal study in particular has shown that uric acid stone formers have a signifi cantly higher prevalence of diabetes and glucose intolerance, and an elevated serum triglyceride concentration compared with normal controls [ 21 ] .…”

confidence: 99%

Urinary calculi and an increased risk of stroke: a population‐based follow‐up study

et al. 2012

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E 1 0 5 3What ' s known on the subject? and What does the study add? Although early studies failed to detect an association between urinary calculi (UC) and subsequent cardiovascular risk, there is growing evidence among more recent research supporting this association with some studies more specifi cally suggesting that stroke is a major concern for UC sufferers. After adjusting for potential confounding factors, UC patients were more likely to have experienced a stroke then those without UC during the fi ve-year follow-up period (hazard ratio = 1.43, 95% Cl = 1.35 -1.50, P < 0.001). OBJECTIVE• To examine in a population-based study the relationship between a history of nephrolithiasis and/or ureterolithiasis and the subsequent risk of stroke, as previous studies have shown that stone disease is associated with several cardiovascular risk factors. However, none of the studies that have investigated the relationship between urinary calculi (UC) and stroke were able to detect an association at a signifi cant level. PATIENTS AND METHODS• We used data sourced from the Taiwan Longitudinal Health Insurance Database 2000.• In all, 25 181 adult patients newly diagnosed with UC were recruited as a study cohort, along with 125 905 matched enrolees with no history of stone disease as a comparison cohort.• All the subjects were tracked for a 5-year period beginning from their index ambulatory care visits, and those who subsequently had a stroke identifi ed.• Cox proportional hazards regressions were used to compare the risk of stroke between the study and comparison cohorts. RESULTS• During the 5-year follow-up period, the incidence rate of stroke was 1.78 (95% confi dence interval [ CI ] 1.71 -1.86) per 100 person-years in patients with UC and 1.25 (95% CI 1.22 -1.27) per 100 person-years in patients without UC.• After adjusting for hypertension, diabetes, hyperlipidaemia, cardiovascular disease, urbanization level, gout, and obesity, patients with UC were more likely to have had a stroke than those without UC during the 5-year follow-up period (hazard ratio 1.43, 95% CI 1.35 -1.50, P < 0.001). CONCLUSION• Our results suggest that there is an increased risk of stroke during the fi rst 5 years after a diagnosis of UC. KEYWORDSurinary calculi , stroke , epidemiology Study Type -Prognosis (cohort) Level of Evidence 2b

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Insulin resistance increases the risk of urinary stone formation in a rat model of metabolic syndrome

Cited by 35 publications

References 23 publications

Association between Prostate Cancer and Urinary Calculi: A Population-Based Study

Association between Prostate Cancer and Urinary Calculi: A Population-Based Study

Association between Body Mass Index, Lipid Profiles, and Types of Urinary Stones

Urinary calculi and an increased risk of stroke: a population‐based follow‐up study

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