Association between Body Mass Index, Lipid Profiles, and Types of Urinary Stones

İnci, Melek; Demirtaş, Abdullah; Şarlı, Bahadır; Akinsal, E.C.; Baydilli, Numan

doi:10.3109/0886022x.2012.713298

Cited by 49 publications

(43 citation statements)

References 41 publications

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“…The finding that DLD is associated with nephrolithiasis, specifically uric acid stones, has been reported previously [6, 9]. Unfortunately, causality of DLD leading to nephrolithiasis has not been established.…”

Section: Discussionmentioning

confidence: 73%

“…Dyslipidemia (DLD) has also begun to receive attention and may have an association with stone disease. Inci et al [6] in Turkey demonstrated that stone formers had elevated triglyceride levels compared to control patients. In Japan, Itoh et al [7] showed that a high cholesterol diet in animal studies could lead to increased renal calcium stone formation.…”

Section: Introductionmentioning

confidence: 99%

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Dyslipidemia is associated with an increased risk of nephrolithiasis

et al. 2014

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The pathophysiology of nephrolithiasis is multifactorial. Obesity, diabetes mellitus and hypertension are implicated in its formation. Dyslipidemia (DLD) recently has received attention as well. Congruent with a vascular etiology in stone formation, DLD theoretically would predispose patients to nephrolithiasis. We investigated a possible association of DLD with nephrolithiasis. A random cohort of 60,000 patients was established by collecting the first 5,000 patient charts per month in the year 2000. After excluding pediatric patients, a retrospective study was performed by reviewing age, sex, comorbidities, and last patient follow-up. Median lipid laboratory levels also were reviewed. Descriptive statistics were performed as well as Cox proportional-hazards regression analysis, and univariate and multivariate analyses. 52,184 (22,717 women/29,467 men) patient charts were reviewed. The average age was 31.0 ± 15.2 years. On univariate analysis, DLD was associated with nephrolithiasis with a hazard ratio (HR) of 2.2 [Confidence Interval (CI), 1.9–2.5; p < 0.001] and on multivariate analysis HR = 1.2 (1.0–1.5; p = 0.033). Low-density lipoprotein and triglycerides had no association with stone disease. Patients with high-density lipoprotein (HDL) values <45 for men and <60 for women had an HR of 1.4 (1.1–1.7, 95% CI, p = 0.003) on univariate analysis and on multivariate analysis; HR = 1.27 (1.03–1.56; p = 0.024) for nephrolithiasis. DLD was associated with an increased risk of stone disease though the only specific lipid panel associated with lower nephrolithiasis was HDL. Clinicians should consider obtaining lipid levels with the intent that treatment could potentially not only mitigate atherosclerotic disease but also decrease nephrolithiasis risk.

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Section: Discussionmentioning

confidence: 73%

Section: Introductionmentioning

confidence: 99%

Dyslipidemia is associated with an increased risk of nephrolithiasis

et al. 2014

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“…22,23 Inci and colleagues found significantly higher TC levels in patients with kidney stones compared to those without, and observed an increase in calcium oxalate and uric acid stones. 23 Pathogenesis between hyperlipidemia and kidney stones in rats has been explained by inflammation and damage in renal tubular cells. 24 In our study, lipid levels were significantly higher in the kidney stone group.…”

Section: Discussionmentioning

confidence: 98%

Visceral obesity: A new risk factor for stone disease

Akarken

Tarhan

Ekin

et al. 2015

CUAJ

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Introduction: We examined the relationship between stone disease and the amount of visceral adipose tissue measured with unenhanced computed tomography (CT). Methods: We included 149 patients with complaints of flank pain and kidney stones detected by CT, from August 2012 to April 2013. In addition, as the control group we included 139 healthy individuals, with flank pain within the same time period, with no previous history of urological disease and no current kidney stones identified by CT. Patients were analyzed for age, gender, body mass index, amount of visceral and subcutaneous adipose tissue, and serum level of low-density lipoprotein and triglyceride. Results: There were no differences between groups in terms of gender and age (p = 0.27 and 0.06, respectively). Respective measurements for the stone and control groups for body mass index were 29.1 and 27.6 kg/m 2 ; for visceral fat measurement 186.0 and 120.2 cm 2 ; and for subcutaneous fat measurements 275.9 and 261.9 cm 2 (p = 0.01; 0.01 and 0.36, respectively). Using multivariate analysis, the following factors were identified as increasing the risk of kidney stone formation: hyperlipidemia (p = 0.003), hypertension (p = 0.001), and ratio of visceral fat tissue to subcutaneous fat tissue (p = 0.01). Our study has its limitations, including its retrospective nature, its small sample size, possible selection bias, and missing data. The lack of stone composition data is another major limitation of our study. Conclusion:The ratio of visceral to subcutaneous adipose tissue, in addition to obesity, hyperlipidemia, and hypertension, was identified as an emerging factor in the formation of kidney stones.

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“…Of these patients with dyslipidemia, nearly 70% had calcium oxalate stones and 15% had uric acid stones. A recent study by Inci and colleagues 55 similarly found that total cholesterol levels were significantly higher in stone formers compared with patients who do not form stones, with the association noted to be particularly prominent for calcium oxalate and uric acid stone formers.…”

Section: Dyslipidemia and Urinary Stone Diseasementioning

confidence: 89%