Insulin Resistance in Type 2 Diabetes Mellitus May Be Related to Bone Mineral Density

Arıkan, Şenay; Tuzcu, Alpaslan; Bahçeci, Mithat; Ozmen, Sehmuz; Gökalp, Deniz

doi:10.1016/j.jocd.2011.11.005

Cited by 35 publications

(34 citation statements)

References 26 publications

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“…Some studies found that insulin resistance was positively associated with bone mass, but this relationship was attenuated by or not significant after adjusting for weight and BMI [10,22]. Recent Korean studies demonstrated an inverse association between insulin resistance and bone mass in men aged ≥20 years [11], whereas other studies reported that insulin resistance was related to a lower BMD in adolescents [23] and patients with T2DM [24]. A recent study also demonstrated that insulin resistance is inversely associated with trabecular and cortical bone size in non-diabetic men at the age of peak bone mass [25].…”

Section: Discussionmentioning

confidence: 99%

Association of insulin resistance with near peak bone mass in the femur and lumbar spine of Korean adults aged 25-35: The Korean National Health and Nutrition Examination Survey 2008-2010

et al. 2017

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ObjectiveThis study aimed to evaluate the relationship between insulin resistance and the bone mineral density (BMD) of femur and lumbar spine in Korean adults who are expected to exhibit near peak bone mass.MethodsData from the Korean National Health and Nutrition Examination Survey 2008–2010 were analyzed. A total of 2,750 participants aged 25−35 years were included. Insulin resistance was assessed using a homeostatic model assessment of insulin resistance (HOMA-IR) and serum fasting insulin.ResultsIn a multivariate linear regression analysis, the HOMA-IR was significantly inversely associated with the BMD of the total hip (TH, β = −0.052, P = 0.002), femoral neck (FN, β = −0.072, P<0.001), femoral trochanter (FTr, β = −0.055, P = 0.003), femoral intertrochanter (FITr, β = −0.041, P = 0.015), and lumbar spine (LS, β = −0.063, P = 0.001) among all study subjects after adjustment for gender, age, height, weight, whole body fat mass percentage, systolic blood pressure, diastolic blood pressure, total cholesterol, triglyceride, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, vitamin D, smoking, alcohol intake, physical activity, education level, and household income in both genders as well as labor, the use of oral contraceptives, and age at menarche in females. The serum fasting insulin was significantly inversely associated with the BMD of the TH (β = −0.055, P = 0.001), FN (β = −0.072, P<0.001), FTr (β = −0.055, P = 0.003), FITr (β = −0.045, P = 0.009), and LS (β = −0.064, P = 0.001) among all subjects in a multivariate linear regression analysis.ConclusionOur results suggest that insulin resistance may be independently and inversely associated with the near peak bone mass of the femur and lumbar spine.

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Section: Discussionmentioning

confidence: 99%

Association of insulin resistance with near peak bone mass in the femur and lumbar spine of Korean adults aged 25-35: The Korean National Health and Nutrition Examination Survey 2008-2010

et al. 2017

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“…However, one study reported adiponectin to be inversely associated with total (β = −0.626, P <0.001), trabecular (β = −0.696, P <0.001), and cortical (β = −1.076, P = 0.001) BMD in women, but not in men [37]. Insulin resistance has a negative effect on BMD [38]. Visceral fat, but not total or subcutaneous fat, is the most significant variable correlating with insulin resistance [39], [40].…”

Section: Discussionmentioning

confidence: 99%

Association of Weight-Adjusted Body Fat and Fat Distribution with Bone Mineral Density in Middle-Aged Chinese Adults: A Cross-Sectional Study

Liu

Wen

et al. 2013

PLoS ONE

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BackgroundAlthough it is well established that a higher body weight is protective against osteoporosis, the effects of body fat and fat distribution on bone mineral density (BMD) after adjustment for body weight remains uncertain.ObjectiveTo examine the relationship between body fat and fat distribution and BMD beyond its weight-bearing effect in middle-aged Chinese adults.MethodThe study had a community-based cross-sectional design and involved 1,767 women and 698 men aged 50–75 years. The BMD of the lumbar spine, total hip, and whole body, and the fat mass (FM) and percentage fat mass (%FM) of the total body and segments of the body were measured by dual-energy X-ray absorptiometry. General information on the participants was collected using structured questionnaire interviews.ResultAfter adjusting for potential confounders, an analysis of covariance showed the weight-adjusted (WA-) total FM (or %FM) to be negatively associated with BMD in all of the studied sites (P<0.05) in both women and men. The unfavorable effects of WA-total FM were generally more substantial in men than in women, and the whole body was the most sensitive site related to FM, followed by the total hip and the lumbar spine, in both genders. The mean BMD of the lumbar spine, total hip, and whole body was 3.93%, 3.01%, and 3.65% (in women) and 5.02%, 5.57%, 6.03% (in men) lower in the highest quartile (vs. lowest quartile) according to the WA-total FM (all p<0.05). Similar results were noted among the groups for WA-total FM%. In women, abdominal fat had the most unfavorable association with BMD, whereas in men it was limb fat.ConclusionFM (or %FM) is inversely associated with BMD beyond its weight-bearing effect. Abdominal fat in women and limb fat in men seems to have the greatest effect on BMD.

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“…Recent small observational studies have shown that IR is associated with decreased BMD [19][20][21] and may play an intermediary role in the 'cross-talk' between NAFLD and low BMD [9,17].…”

Section: Putative Mechanisms Linking Nafld With Low Bmdmentioning

confidence: 99%

Nonalcoholic fatty liver disease and decreased bone mineral density: is there a link?

Targher

Lonardo

Rossini

2015

J Endocrinol Invest

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Insulin Resistance in Type 2 Diabetes Mellitus May Be Related to Bone Mineral Density

Cited by 35 publications

References 26 publications

Association of insulin resistance with near peak bone mass in the femur and lumbar spine of Korean adults aged 25-35: The Korean National Health and Nutrition Examination Survey 2008-2010

Association of insulin resistance with near peak bone mass in the femur and lumbar spine of Korean adults aged 25-35: The Korean National Health and Nutrition Examination Survey 2008-2010

Association of Weight-Adjusted Body Fat and Fat Distribution with Bone Mineral Density in Middle-Aged Chinese Adults: A Cross-Sectional Study

Nonalcoholic fatty liver disease and decreased bone mineral density: is there a link?

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