Association of insulin resistance with near peak bone mass in the femur and lumbar spine of Korean adults aged 25-35: The Korean National Health and Nutrition Examination Survey 2008-2010

Choo, Min Soo; Choi, Se Rin; Han, Jun Hyun; Lee, Seong Ho; Shim, Young‐Soo

doi:10.1371/journal.pone.0177311

Cited by 13 publications

(11 citation statements)

References 46 publications

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“…Our finding that insulin sensitivity was positively associated with total, leg and arm BMD is supported by two large studies which showed that after adjustment for weight or fat mass, the association of insulin resistance (using fasting insulin or HOMA‐IR) with BMD changed in direction from positive to negative, and this was apparent for total, hip and femoral neck BMD . However, in contrast to our finding of no association in predominantly middle‐aged males, Choo et al, studying peak bone mass in young adults, found that increasing insulin sensitivity was positively associated with lumbar spine BMD . Further studies will be needed to resolve whether variation in exercise might underlie this association.…”

Section: Discussionsupporting

confidence: 86%

“…Reduction in fracture risk associated with obesity is possibly related to its shock‐absorbing effect . Secondly, while there has been evidence for insulin resistance having an adverse effect on total, hip and femoral neck BMD, this may not be a global effect. Our study showed that insulin sensitivity is positively associated with total, leg and arm BMD, but not with other regional BMDs, including spine.…”

Section: Discussionmentioning

confidence: 86%

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Independent relationships between bone mineral density, regional body fat and insulin sensitivity in white males

Loh

Stevenson

Godsland

2019

Clinical Endocrinology

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Variation in bone mineral density (BMD) has been related to variation in weight, 1 adiposity, 2 insulin sensitivity and plasma insulin concentrations. [3][4][5] However, on account of mutual confounding and the colinearity between these explanatory measures, there is uncertainty regarding the independent contribution each makes to variation in BMD. 6 For example, the mechanical loading effect of increasing weight is associated with increasing BMD 1 but increasing weight is often associated with increasing fat mass. Therefore, AbstractBackground: Adiposity and insulin sensitivity may affect bone mineral density (BMD), but the confounding effect of weight hinders discrimination of independent associations. We explored whether regional fat masses and insulin sensitivity are independently related to BMD. Materials and methods:Relationships between total and regional body fat, insulin sensitivity and measures of BMD in 8 different regions were evaluated in a cross section of 590 generally healthy, white males, 274 of whom received measurement of insulin sensitivity (Si) using the intravenous glucose tolerance test. Measurements included total, android and gynoid fat and lean body mass and regional BMDs by dual-energy X-ray absorptiometry. Linear regression analyses were combined in a mediation analysis to explore associations with each regional BMD. Results:Weight correlated positively with total fat mass (R 2 = 0.67, P < 0.001) and negatively with Si (R 2 = 0.14, P < 0.001). Body composition measures were consistently positively related to BMD in all regions except lumbar and thoracic spine.Accounting for body weight rendered negative majority of associations between total and regional fat masses and BMDs. An independent association between android fat and spine BMD was particularly apparent. Si was positively associated with total and limb BMD (P < 0.01) specifically among exercisers. Accounting for Si diminished the associations of total fat (negative) and lean body mass (positive) with total and limb BMD. Conclusion:Android fat is independently negatively associated with spine BMD.Among those taking exercise, increased insulin sensitivity is associated with higher limb BMD and may underlie positive associations between lean body mass and BMD. K E Y W O R D Sandroid fat, bone mineral density, dual-energy X-ray absorptiometry, insulin sensitivity, mediation analysis

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Section: Discussionsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 86%

Independent relationships between bone mineral density, regional body fat and insulin sensitivity in white males

Loh

Stevenson

Godsland

2019

Clinical Endocrinology

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“…Nevertheless, an inverse association was noted after adjustment for fat mass. Hence, IR may affect the association between insulinemia and bone mass, and investigations on different populations may yield inconsistent results (15)(16)(17)(18)(19)(20). We examined the joint effect of HOMA-IR and HOMA-b on osteoporosis (Table 5).…”

Section: Discussionmentioning

confidence: 99%

“…Insulinemia has been associated with a higher BMD (15,16), while IR has been inversely associated with bone mass (17,18). Findings in previous studies are not consistent (15)(16)(17)(18)(19)(20).…”

Section: Introductionmentioning

confidence: 98%

Associations of insulin resistance and insulin secretion with bone mineral density and osteoporosis in a general population

Liu

Lee

et al. 2022

Front. Endocrinol.

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We investigated the associations of insulin resistance and β-cell secretion with bone mineral density (BMD) and osteoporosis using data from the National Health and Nutrition Examination Survey. Data on BMD assessed using dual-energy x-ray absorptiometry from 5292 participants were analyzed. Insulin resistance and β-cell secretion were assessed using the Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) and β-cell function (HOMA-β), respectively. We divided the study population into four groups according to HOMA-IR (<2 vs. ≥ 2) and HOMA-β (<100 vs. ≥ 100). BMD and T score at the lumbar spine, hip joint, and femur were used for analyses. Osteoporosis was defined as a T score ≤ -2.5. Logistic regression analyses were conducted to examine the associations of HOMA-IR and HOMA-β with osteoporosis, and the joint effects of HOMA-IR and HOMA-β on osteoporosis. We found a positive association between HOMA-IR and osteoporosis in participants with a HOMA-β ≥ 100 (OR 8.773, 95% CI 2.160-35.637, p=0.002 at the femoral neck). A negative association between HOMA-β and osteoporosis was noted in those with a HOMA-IR <2 (OR 0.183, 95% CI 0.038-0.882, p=0.034 at the femoral neck). Compared with participants who had HOMA-IR <2 and HOMA-β <100, those with HOMA-IR <2 and HOMA-β ≥ 100 had a lower risk of osteoporosis (OR 0.126, 95% CI 0.020-0.805, p=0.032 at the femoral neck). In conclusion, the association between HOMA-β and BMD/osteoporosis changed as HOMA-IR increased. HOMA-β was negatively associated with osteoporosis when HOMA-IR <2. The association was not significant when HOMA-IR ≥ 2.

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“…Indeed, individuals with BN have a higher risk of DM2 (RAEVUORI et al, 2015) as mentioned previously. Data from the Korean National Health and Nutrition Examination Survey of adults aged 25 to 35 years found that insulin resistance was negatively associated with peak bone mass at the lumbar spine and femur (CHOO et al, 2017). The cortical and trabecular bone sizes were also inversely associated with insulin resistance in men at the age of peak bone mass (VERROKEN et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

Avaliação da saúde óssea em pacientes com anorexia nervosa e bulimia nervosa

Lopes¹

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Esta tese é fruto de um longo trabalho e muita dedicação. Gostaria de agradecer aqui todas as pessoas e instituições fundamentais para o desenvolvimento do meu doutorado:Primeiramente à minha orientadora Ligia Martini, por desde cedo me guiar e acolher no mundo da pesquisa. Por ter acreditado e confiado em mim, contribuindo para o desenvolvendo das minhas habilidades acadêmicas e pessoais. Obrigada por ser meu porto seguro em meio aos desafios e dificuldades inerentes ao doutorado. À minha coorientadora Marle Alvarenga, pelo suporte na realização de uma pesquisa com um tema tão interessante e desafiador quanto os transtornos alimentares. Obrigada por me inspirar uma visão de nutrição cada vez mais humana e gentil. E aos alunos da Profª Ligia e Marle:

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Association of insulin resistance with near peak bone mass in the femur and lumbar spine of Korean adults aged 25-35: The Korean National Health and Nutrition Examination Survey 2008-2010

Cited by 13 publications

References 46 publications

Independent relationships between bone mineral density, regional body fat and insulin sensitivity in white males

Independent relationships between bone mineral density, regional body fat and insulin sensitivity in white males

Associations of insulin resistance and insulin secretion with bone mineral density and osteoporosis in a general population

Avaliação da saúde óssea em pacientes com anorexia nervosa e bulimia nervosa

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