Insulin Resistance in Obese Children and Adolescents: HOMA-IR Cut-Off Levels in the Prepubertal and Pubertal Periods - Original Article

Kurtoğlu, Selim; Hatipoğlu, Nihal; Mazıcıoğlu, Mumtaz M.; Kendirici, Mustafa; Keskın, Mehmet; Kondolot, Meda

doi:10.4274/jcrpe.v2i3.100

Cited by 275 publications

(282 citation statements)

References 40 publications

(58 reference statements)

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“…Scores ordinarily range from 0 to 15; higher scores indicate greater insulin resistance. The degree of insulin resistance was determined using cutoff of 3.1 because this value was representative of insulin resistance in both adults and children (19). In adults, hemoglobin A1c (HbA1c) was measured as a marker for long-term mean plasma glucose concentration.…”

Section: Clinical Investigationmentioning

confidence: 99%

Altered Distribution and Increased IL-17 Production by Mucosal-Associated Invariant T Cells in Adult and Childhood Obesity

Carolan

Tobin

Mangan

et al. 2015

The Journal of Immunology

143

150

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Mucosal-associated invariant T (MAIT) cells are innate MHC-unrestricted cells that regulate inflammatory responses through the rapid production of cytokines. In this article, we show that circulating MAIT cells are depleted in obese adults, and depletion is associated with diabetic status. Circulating MAIT cells more frequently produced IL-17 upon stimulation ex vivo, a cytokine implicated in insulin resistance. MAIT cells were enriched in adipose tissue (AT) compared with blood. AT MAIT cells, but not circulating MAIT cells, were capable of producing IL-10. In AT from obese subjects, MAIT cells were depleted, were less likely to produce IL-10, and more frequently produced IL-17. Finally, we show that IL-17+ MAIT cells are also increased in childhood obesity, and altered MAIT cell frequencies in obese children are positively associated with insulin resistance. These data indicate that MAIT cells are enriched in human AT and display an IL-17+ phenotype in both obese adults and children, correlating with levels of insulin resistance. The alterations in MAIT cells may be contributing to obesity-related sterile inflammation and insulin resistance.

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Section: Clinical Investigationmentioning

confidence: 99%

Altered Distribution and Increased IL-17 Production by Mucosal-Associated Invariant T Cells in Adult and Childhood Obesity

Carolan

Tobin

Mangan

et al. 2015

The Journal of Immunology

143

150

View full text Add to dashboard Cite

show abstract

“…HOMA-IR is more reliable than FGIR and QUICKI. [22] and has good correlation with euglycaemic clamp, even though its relatively low precision puts limits on its use. [23] In our study, although most students had apparently normal plasma glucose and plasma insulin, prevalence of insulin resistance by HOMA-IR cutoff >=2 was high at 40%.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Insulin Resistance and its Association with Obesity and Alcoholism in Male Medical Students of Bhopal

Charpe¹,

Biswas²,

Jain³

2017

IJLSSR

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ABSTRACT-Background: Obesity is rising in medical students due to their stressful academic calendar and sparse time for sports. Obesity is aggravated by the regular drinking of alcohol, a recreational and stress-busting activity, particularly for the male students. Obesity leads to insulin resistance. Homeostasis model assessment-estimated insulin resistance (HOMA-IR) >2 has been reported to independently predict cardiovascular risk. Although many studies are there on obesity of medical students, few studies exist in Central India on the prevalence of insulin resistance in medical students. Therefore, prevalence of insulin resistance and its association with obesity and alcoholism was investigated in the first year male medical students of LN Medical College, Bhopal, India. Methods: 50 male medical students of first year were investigated and considered overweight/obese if BMI>=23 or centrally obese if waist circumference (WC)>=90cm. Alcohol intake of more than 20gm per day was considered as high alcohol intake. HOMA-IR was calculated from fasting glucose and fasting insulin, whereas HOMA-IR>=2 was regarded as high. Results: Insulin resistance measured by HOMA-IR>=2 was found in 40%, central obesity as per waist circumference in 20%, overall obesity/overweight as per BMI in 60% and alcoholism in 42%. Significant association was found between insulin resistance and central obesity measured by waist circumference (p value 0.001), but not with BMI and alcoholism. Conclusion: Prevalence of insulin resistance in first year male medical students was high and insulin resistance was significantly associated with central obesity.

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“…Recent studies suggest that low levels of physical activity tend to increase the risk of obesity in children. The lack of sufficient areas suitable for walking and cycling in urban planning has been reported to be related to obesity as it results in children's preferring to stay indoors and watching TV (34).…”

Section: Discussionmentioning

confidence: 99%

Factors Affecting the Risk of Childhood Obesity in the Bağcılar region of İstanbul

Erol¹,

Yiğit²,

Zengi³

et al. 2017

JAREM

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Objective: Childhood obesity has recently become a common health problem worldwide. In the struggle against obesity, studies have focused on the risk factors playing a role in the development of obesity. In this study, we assessed the risk factors playing a role in childhood obesity and the resulting obesity in the İstanbul Bağcılar Region. Methods:In total, 250 obese children, aged 4-15 years, and 98 non-obese children of the same age were included in this study. A standardized questionnaire aimed at determining the sociodemographic characteristics, television-watching schedule, nutritional habits, physical activity, presence of obesity in the family, and duration of breastfeeding was provided to the study and control groups. Glucose, insulin, cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL), and triglyceride levels were measured in fasting serum samples. Homeostasis model assessment-insulin resistance (HOMA-IR) values were calculated. Results:The mean age of the study group was 10.71±2.69 years; there were 112 (44.80%) males and 138 (55.20%) females. The pubertal period (p=0.0001), the presence of obese individuals in the family (p=0.021), and watching television for more than 3 h per day (p=0.0001) were found to be risk factors for childhood obesity. Increased HOMA-IR (p=0.0001), increased fasting insulin (p=0.003), and decreased HDL (p=0.037) levels were the most influential parameters in obesity. Conclusion:Childhood obesity can lead to serious health problems by affecting obesity in adulthood. To initially prevent obesity requires a full understanding of the risk factors and biological and social pathways leading to obesity in early life.

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Insulin Resistance in Obese Children and Adolescents: HOMA-IR Cut-Off Levels in the Prepubertal and Pubertal Periods - Original Article

Cited by 275 publications

References 40 publications

Altered Distribution and Increased IL-17 Production by Mucosal-Associated Invariant T Cells in Adult and Childhood Obesity

Altered Distribution and Increased IL-17 Production by Mucosal-Associated Invariant T Cells in Adult and Childhood Obesity

Prevalence of Insulin Resistance and its Association with Obesity and Alcoholism in Male Medical Students of Bhopal

Factors Affecting the Risk of Childhood Obesity in the Bağcılar region of İstanbul

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