Insulin Resistance in Hispanic Large-for-Gestational-Age Neonates at Birth

Dyer, Jennifer; Rosenfeld, Charles R.; Rice, Julie; Rice, Mark; Hardin, Dana S.

doi:10.1210/jc.2007-0079

Cited by 46 publications

(41 citation statements)

References 40 publications

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“…In Pima Indians, fetal overgrowth was associated with higher systolic blood pressure at the age of 7-11 years (32). Our findings demonstrated that this unfavorable metabolic profile persists until adult life, as previously suggested in newborn and children born LGA (2,27,31). Thus, one of the important findings in this study is that being born LGA has long lasting consequences, and these subjects are indeed at higher risk of developing metabolic syndrome later in life.…”

Section: Discussionsupporting

confidence: 85%

“…Some previous data showed reduced insulin sensitivity in LGA newborns (27) and increased fat accumulation during childhood in LGA subjects (2,31). In Pima Indians, fetal overgrowth was associated with higher systolic blood pressure at the age of 7-11 years (32).…”

Section: Discussionmentioning

confidence: 86%

“…Asymmetric overgrowth is a common outcome of gestational diabetes, but it has been observed that LGA offspring of both diabetic and nondiabetic mothers presents abnormalities in insulin sensitivity (5,27). It has been speculated that the body composition at birth influences cardiometabolic risk in LGA subjects (28,29).…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Adiponectin: serum levels, promoter polymorphism, and associations with birth size and cardiometabolic outcome in young adults born large for gestational age

Bueno

Espineira²,

Fernandes-Rosa³

et al. 2010

European Journal of Endocrinology

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Objective: To assess whether the K11391GOA polymorphism in the regulatory region of the adiponectin gene (ADIPOQ) is associated with birth size, postnatal growth, adiponectinemia, and cardiometabolic risk in adult life. Design: Case-control study nested within a prospective cohort of 2063 community subjects born in 1978/1979 and followed since birth to date. Methods: ADIPOQ K11391GOA genotype-phenotype associations were evaluated in 116 subjects born large for gestational age (LGA) and 392 gender-matched controls at birth (birth size), at 8-10 years (catch-down growth), and at 23-25 years of age (cardiometabolic profile). Results: The K11391A variant allele frequency was higher in LGA subjects (PZ0.04). AA genotype was associated with augmented probability of being born LGA (odds ratioZ4.14; 95% confidence interval: 1.16-16.7; PZ0.03). This polymorphism was associated neither with body composition nor with postnatal growth pattern. At the age of 23-25 years, the K11391A variant allele was associated with higher serum adiponectin levels (GG: 10.7G6.2 versus GA: 12.2G6.5 versus AA: 14.2 G6.8 mg/ml; P!0.01). Subjects born LGA presented higher body mass index (BMI; PZ0.01), abdominal circumference (PZ0.04), blood pressure (PZ0.04), and homeostasis assessment model for insulin resistance (PZ0.01) than adequate for gestational age. Symmetry at birth did not influence these variables. The occurrence of catch-down of weight was associated with lower BMI and abdominal circumference (P!0.001) at 23-25 years. Conclusions: The K11391A ADIPOQ gene variant was associated with increased chance of being born LGA and with higher adiponectin levels in early adult life.

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Section: Discussionsupporting

confidence: 85%

Section: Discussionmentioning

confidence: 86%

See 1 more Smart Citation

Adiponectin: serum levels, promoter polymorphism, and associations with birth size and cardiometabolic outcome in young adults born large for gestational age

Bueno

Espineira²,

Fernandes-Rosa³

et al. 2010

European Journal of Endocrinology

View full text Add to dashboard Cite

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“…However, some studies demonstrate that children born LGA have as well an increased risk of developing obesity, insulin resistance, metabolic syndrome, diabetes and early cardiovascular disease [5][6][7][8][9]. Furthermore Toschke et al [10] showed that rapid weight gain from birth to 2 years was associated with a higher prevalence of overweight at school entry.…”

Section: Introductionmentioning

confidence: 99%

Effect of Post-Natal Catch-Down and Feeding Practices on Auxology, Body Composition and Muscle Function in Children Born Large-For-Gestational-Age

Peters¹,

Woelfle²,

Joergens³

et al. 2017

J Diabetes Metab

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“…Endometrial environment via its role in fetal growth is important for programming of future metabolic diseases during adult life (3,7).…”

Section: Introductionmentioning

confidence: 99%

The role of maternal gut hormones in normal pregnancy: fasting plasma active glucagon-like peptide 1 level is a negative predictor of fetal abdomen circumference and maternal weight change

Valsamakis

Margeli

Vitoratos

et al. 2010

European Journal of Endocrinology

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Objective: Maternal weight in pregnancy contributes to a glycemic environment that affects fetal growth. Gut peptides (glucagon-like peptide 1 (GLP1), glucose-dependent insulinotropic peptide (GIP), ghrelin, and peptide YY (PYY)) have been related to insulin sensitivity and secretion, weight control, and adipose tissue metabolism. This study aimed at examining the associations of gut hormones during pregnancy with maternal glucose homeostasis, maternal weight, and fetal growth. Methods: A total of 55 pregnant nonobese, nondiabetic Caucasian women were examined during the three trimesters of pregnancy, and anthropometric measurements, evaluation of fasting maternal plasma GLP1 (active), ghrelin (active), total PYY, total GIP, and a 75-g oral glucose tolerance test were done in them. Homeostasis model assessment (HOMA-R), insulin sensitivity index (ISI), and indices of insulin secretion were calculated. Fetal growth was estimated by ultrasound. Results: Fasting GLP1 increased significantly from the second to the third trimester (P!0.05). Fasting GLP1 correlated positively with high-density lipoprotein cholesterol (rZ0.52, PZ0.04). At the second trimester, fasting GLP1 levels correlated negatively with fetal abdomen circumference (rZK0.55, PZ0.034), birth weight (rZK0.50, PZ0.040), HOMA-R (rZK0.65, PZ0.001), insulin secretion, and triglycerides. At the first trimester, fasting ghrelin levels correlated negatively with HOMA-R and insulin secretion, and positively with ISI. In backward multiple regression analysis, the first trimester GLP1 levels were the best negative predictors of the second trimester fetal abdomen circumference (bZK0.96, PZ0.009). In longitudinal regression model, maternal fat and HOMA-R were the positive predictors of maternal weight change during pregnancy, and fasting GLP1 levels were the negative predictors of maternal weight change during pregnancy. Conclusions: During pregnancy, maternal GLP1 might be involved in mechanisms that compensate for the pregnancy-related increase in glycemia and insulin resistance, suggesting a role of this peptide in maternal metabolism and weight and fetal growth.

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Insulin Resistance in Hispanic Large-for-Gestational-Age Neonates at Birth

Abstract: Reduced insulin sensitivity is present soon after birth in Hispanic large-for-gestational-age neonates born to mothers with and without gestational diabetes, demonstrating the onset of insulin resistance before birth and evidence of altered fetal programming.

Cited by 46 publications

References 40 publications

Adiponectin: serum levels, promoter polymorphism, and associations with birth size and cardiometabolic outcome in young adults born large for gestational age

Adiponectin: serum levels, promoter polymorphism, and associations with birth size and cardiometabolic outcome in young adults born large for gestational age

Effect of Post-Natal Catch-Down and Feeding Practices on Auxology, Body Composition and Muscle Function in Children Born Large-For-Gestational-Age

The role of maternal gut hormones in normal pregnancy: fasting plasma active glucagon-like peptide 1 level is a negative predictor of fetal abdomen circumference and maternal weight change

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