Insulin resistance in clomiphene responders and non‐responders with polycystic ovarian disease and therapeutic effects of metformin

Parsanezhad, Mohammad Ebrahim; Alborzi, Saeed; Zarei, Afsoon; Dehbashi, Sanaz; Omrani, Gholamreza

doi:10.1016/s0020-7292(01)00470-2

Cited by 34 publications

(29 citation statements)

References 19 publications

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“…Melissa et al [17] reported that the rates of PCOS in mothers and sisters of patients with PCOS were 24% and 32% respectively. It has been widely recognized in the last decade that several features of metabolic syndrome (MS), particularly insulin resistance and hyperinsulinemia, are inconsistently present in the majority of women with PCOS [18][19][20][21].…”

Section: Introductionmentioning

confidence: 99%

Polycystic Ovarian Syndrome in Perimenopausal Women: A Pilot Study

Chhabra¹,

Taori²

2015

Reprod Syst Sex Disord

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Section: Introductionmentioning

confidence: 99%

Polycystic Ovarian Syndrome in Perimenopausal Women: A Pilot Study

Chhabra¹,

Taori²

2015

Reprod Syst Sex Disord

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“…Polycystic ovarian syndrome (PCOS) is a form of functional ovarian hyperandrogenism which affects approximately 5-10 % of women of reproductive age [1]. It is the most common cause of female infertility and is characterized by ovarian hyperandrogenism and chronic anovulation [2].…”

Section: Introductionmentioning

confidence: 99%

“…Insulin resistance with compensatory hyperinsulinemia appears to be the most universal feature of the polycystic ovarian disease and has a pathophysiologic role in the hyperandrogenism of the disorder [2]. Nearly 20 % of obese women with PCOS have an impaired glucose tolerance test or diabetes [1].…”

Section: Introductionmentioning

confidence: 99%

Serum Levels of Anti-histone and Anti-double-Strand DNA Antibodies Before and After Laparoscopic Ovarian Drilling in Women with Polycystic Ovarian Syndrome

Samsami

Razmjoei

Parsanezhad

2013

J Obstet Gynecol India

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Objectives To determine the serum levels of anti-dsDNA, anti-histone, and anti-nucleosome antibodies after laparoscopic ovarian electrocauterization in patients with polycystic ovarian syndrome (PCOS). Methods Our study was performed on 35 patients with PCOS resistant to medical therapy, 35 patients with unexplained infertility, and 35 healthy fertile individuals. Patients with PCOS underwent laparoscopic electrocauterization while those with unexplained infertility underwent diagnostic laparoscopy. Serum levels of anti-dsDNA, anti-histone, and anti-nucleosome antibodies were measured at baseline and 1 month after operation and were compared between groups.

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“…Clomiphene resistance is common and occurs in »15-40% in women with PCOS [2, 13]. Insulin resistance, hyperandrogenemia and obesity represent the major factors involved in CC resistance; it prevent the ovaries from responding to raised endogenous follicle-stimulating hormone (FSH) levels following CC therapy [22][23][24]. Moreover, a genetic predisposition was suggested [25].…”

Section: Introductionmentioning

confidence: 99%

Clomiphene citrate alternatives for the initial management of polycystic ovary syndrome: an evidence-based approach

Hashim

2012

Arch Gynecol Obstet

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Polycystic ovary syndrome (PCOS) is a prevalent and heterogeneous condition affecting 4-8% of reproductive age women. It is the most common cause of chronic anovulation and is associated with hyperandrogenemia. Clomiphene citrate (CC) is considered as the first-line therapy for ovulation induction in these patients. Despite progress in understanding the pathophysiology of PCOS over the past 20 years, many questions persist to the extent that PCOS was described as "A Riddle Wrapped in a Mystery inside an Enigma". On the other hand, a recent publication from the Centers for Disease Control suggested that CC may be associated with an increased risk of birth defects. The purpose of this review is to critically evaluate and summarize the current literature regarding CC alternatives for the initial management of PCOS focusing specifically on the roles of weight loss and other approaches to ovulation induction as insulin-sensitizing drugs, aromatase inhibitors, minimal stimulation protocol, gonadotrophins and surgery (laparoscopic ovarian drilling). Finally, the efficacy of intrauterine insemination with CC for the initial management of PCOS will be evaluated.

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Insulin resistance in clomiphene responders and non‐responders with polycystic ovarian disease and therapeutic effects of metformin

Abstract: PCOD is associated with insulin resistance (IR) particularly in CC-resistant women. Insulin resistance and androgen levels are significantly higher in obese patients. MTF therapy improved hyperandrogenemia, IR, and pregnancy rate.

Cited by 34 publications

References 19 publications

Polycystic Ovarian Syndrome in Perimenopausal Women: A Pilot Study

Polycystic Ovarian Syndrome in Perimenopausal Women: A Pilot Study

Serum Levels of Anti-histone and Anti-double-Strand DNA Antibodies Before and After Laparoscopic Ovarian Drilling in Women with Polycystic Ovarian Syndrome

Clomiphene citrate alternatives for the initial management of polycystic ovary syndrome: an evidence-based approach

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