Insulin resistance correlates with maculopathy and severity of retinopathy in young adults with Type 1 Diabetes Mellitus

Rowe, Christopher W; Haider, Ali S; Vaidehi, V.; Jones, Mark; Attia, John; Wynne, Katie; Acharya, Shamasunder

doi:10.1016/j.diabres.2017.06.022

Cited by 6 publications

(5 citation statements)

References 28 publications

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“…The level of IL-6 has been reported linearly associated with an increase of neovascularization activity in PDR 244 . Moreover, a cross-sectional study confirmed a relationship between IR and severity of retinopathy in diabetic patients 245 . Together, these results imply that IL-6 might be critical in mediating insulin-induced vascular remodelling.…”

Section: Discussionmentioning

confidence: 69%

The role of IL-6-174 G/C polymorphism and intraocular IL-6 levels in the pathogenesis of ocular diseases: a systematic review and meta-analysis

Ulhaq

Soraya

Budu

et al. 2020

Sci Rep

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Interleukin-6 (IL-6) is one of the key regulators behind the inflammatory and pathological process associated with ophthalmic diseases. The role of IL-6-174 G/C polymorphism as well as intraocular IL-6 levels among various eye disease patients differ across studies and has not been systematically reviewed. Thus, this study aims to provide a summary to understand the relationship between IL-6 and ophthalmic disease. In total, 8,252 and 11,014 subjects for IL-6-174 G/C and intraocular levels of IL-6, respectively, were retrieved from PubMed, Scopus and Web of Science. No association was found between IL-6-174 G/C polymorphisms with ocular diseases. Subgroup analyses revealed a suggestive association between the GC genotype of IL-6-174 G/C with proliferative diabetic retinopathy (PDR). Further, the level of intraocular IL-6 among ocular disease patients in general was found to be higher than the control group [standardized mean difference (SMD) = 1.41, 95% confidence interval (CI) 1.24–1.58, P < 0.00001]. Closer examination through subgroup analyses yielded similar results in several ocular diseases. This study thus indicates that the IL-6-174 G/C polymorphism does not predispose patients to ocular disease, although the GC genotype is likely to be a genetic biomarker for PDR. Moreover, intraocular IL-6 concentrations are related to the specific manifestations of the ophthalmic diseases. Further studies with larger sample sizes are warranted to confirm this conclusion.

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Section: Discussionmentioning

confidence: 69%

The role of IL-6-174 G/C polymorphism and intraocular IL-6 levels in the pathogenesis of ocular diseases: a systematic review and meta-analysis

Ulhaq

Soraya

Budu

et al. 2020

Sci Rep

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“…22 Patients with DR have two to four times the risk of developing cardiovascular events as those without DR. 23 PStudies have revealed that IR is correlated with severe DR in type 1 diabetes, especially in PDR. 24,25 HOMA-IR is calculated based on FPG and insulin, 16 mainly reflecting the state of glucose metabolism, while the TyG index is calculated on the basis of FPG and TGs, 10 representing the joint effects of glucose and lipids.…”

Section: Dovepressmentioning

confidence: 99%

The Triglyceride–Glucose Index is Associated with Diabetic Retinopathy in Chinese Patients with Type 2 Diabetes: A Hospital-Based, Nested, Case–Control Study

Yao¹,

Wang²,

Zhong³

et al. 2021

DMSO

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Background This study aimed to investigate the association between the triglyceride–glucose (TyG) index and diabetic retinopathy (DR) in Chinese patients with type 2 diabetes. Methods In this nested case–control study, all diabetic participants were registered hospitalizations during 2012–2018, including 596 with DR as cases and three matching controls per case. DR was assessed using Early Treatment Diabetic Retinopathy Study criteria. The TyG index was calculated: Ln (fasting blood glucose [mg/dL] × fasting triglycerides [mg/dL] ÷ 2). Multivariate logistic regression, a receiver-operating characteristic (ROC) curve, linear regression models, and mediation analysis were used to explore associations. Results The TyG index was lower in DR and decreased as its severity advanced among 2,112 subjects ( P =0.005). After confounders (sex, duration of diabetes, use of antidiabetic agents, heart rate, systolic blood pressure, pulse pressure, height, weight, body-mass index, and glycated hemoglobin) had been accounted for, there were significant associations between the TyG index and any-severity DR (OR 0.83, 95% CI 0.73–0.95; P =0.006), as well as vision-threatening DR (VTDR; OR 0.53, 95% CI 0.36–0.76; P =0.001). ROC analysis indicated that the TyG index showed significant discriminatory ability in any-severity DR (area under curve [AUC] 0.534, P =0.015) and VTDR (AUC 0.624, P =0.001). Conclusion The TyG index was associated with the presence and severity of DR. Our findings suggest that the TyG index may become a useful biomarker in evaluating and following the presence of DR and VTDR.

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Section: Discussionmentioning

confidence: 84%

“…Moreover, Rowe et al confirmed a relationship between IR and more severe DR in patients with type 1 DM. 33 It was also demonstrated by Duţă et al 34 that eGDR was the most important factor of proliferative DR. The use of eGDR has been recently advocated as a useful way to assess IR.Several studies have demonstrated that a lower eGDR is associated with higher IR.…”

mentioning

confidence: 84%

Relationship Between Estimated Glucose Disposal Rate and Type 2 Diabetic Retinopathy

Meng¹,

Xing²,

Huo³

et al. 2023

DMSO

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Purpose To investigate the association between diabetic retinopathy (DR), DR intensity, and estimated glucose disposal rate (eGDR) in individuals with type 2 diabetes mellitus (T2DM). Patients and Methods This study comprised 1762 T2DM patients who were admitted between January and December, 2021. Overall, the DR was identified in 430 patients. Based on the eGDR, the participants were divided into four study groups. One-way analysis of variance was used to compare the groups. The correlations between eGDR and DR risk, eGDR, and DR severity were analyzed using regression analysis. Furthermore, these relationships were analyzed in different sex groups. Results Patients with T2DM had a 19.75% (348/1762) DR detection rate, whereas those with DR had a 22.41% (78/348) proliferative DR detection rate. The DR group had substantially reduced levels of eGDR compared with the non-DR group. Multivariate logistic regression analysis demonstrated that reduced eGDR was an independent risk factor for DR, after adjusting for confounding variables. eGDR correlated significantly with proliferative DR in women but not in men. Conclusion In Chinese individuals with T2DM, lower eGDR was independently associated with a higher risk of DR.

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Insulin resistance correlates with maculopathy and severity of retinopathy in young adults with Type 1 Diabetes Mellitus

Cited by 6 publications

References 28 publications

The role of IL-6-174 G/C polymorphism and intraocular IL-6 levels in the pathogenesis of ocular diseases: a systematic review and meta-analysis

The role of IL-6-174 G/C polymorphism and intraocular IL-6 levels in the pathogenesis of ocular diseases: a systematic review and meta-analysis

The Triglyceride–Glucose Index is Associated with Diabetic Retinopathy in Chinese Patients with Type 2 Diabetes: A Hospital-Based, Nested, Case–Control Study

Relationship Between Estimated Glucose Disposal Rate and Type 2 Diabetic Retinopathy

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