Insulin Resistance and Skin Tags

Mathur, Sandeep Kumar; Bhargava, Puneet

doi:10.1159/000245731

Cited by 40 publications

(43 citation statements)

References 6 publications

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“…The first purpose of this study was to evaluate the relationship between skin tags and obesity, hypertension, dyslipidemia and insulin resistance. Dermatological changes have been reported in patients with obesity due to insulin resistance (acanthosis nigricans and skin tags) [3,5,19,20]. Skin tags commonly develop in individuals with obesity and were observed in up to 74% of patients in one study; their prevalence correlated positively with the severity of the obesity [3,4].…”

Section: Discussionmentioning

confidence: 99%

“…They are thought to be relatively common skin lesions and it has been reported that they might reflect insulin resistance states. Age, obesity, atherogenic lipid profile are also associated with skin tags [1][2][3][4][5][6][7][8][9]. Moreover, obesity, dyslipidemia, hypertension, hyperglycemia, hyperinsulinemia, hyperleptinemia are known to be associated with insulin resistance.…”

Section: Introductionmentioning

confidence: 99%

“…Two recent studies showed that skin tags are commonly associated with overt diabetes and impaired glucose tolerance [5,14]. Although there have been a few reports that the presence of skin tags is associated with diabetes mellitus, hypertension, obesity and atherogenic lipid profile [1][2][3][4][5][6][7][8][9]14], no data in the literature show that the presence of skin tags is associated with elevations of serum hs-CRP, uric acid, free fatty acid and leptin level in patients with normal glucose tolerance.…”

Section: Introductionmentioning

confidence: 99%

“…Although there have been a few reports that the presence of skin tags is associated with diabetes mellitus, hypertension, obesity and atherogenic lipid profile [1][2][3][4][5][6][7][8][9]14], no data in the literature show that the presence of skin tags is associated with elevations of serum hs-CRP, uric acid, free fatty acid and leptin level in patients with normal glucose tolerance. The aim of this study was to evaluate the frequency of hypertension, dyslipidemia, obesity and to investigate insulin resistance, serum hs-CRP, uric acid and serum leptin levels in normal glucose tolerant patients with skin tags who were admitted to our dermatology outpatient clinic.…”

Section: Introductionmentioning

confidence: 99%

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The metabolic profile in patients with skin tags

et al. 2009

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Although skin tags are associated with diabetes mellitus, insulin resistance, hypertension, obesity, atherogenic lipid profile, no data in the literature show that the presence of skin tags is associated with serum high-sensitive C-reactive protein, uric acid, free fatty acid and leptin level. The purpose of this study was to evaluate the frequency of hypertension, dyslipidemia, insulin resistance and obesity in patients with skin tags and to compare patients with skin tags and normal healthy subjects for insulin resistance, serum lipids, insulin, glucose, leptin, high-sensitive C-reactive protein, free fatty acid levels. We evaluated 113 patients with skin tags and 31 healthy subjects. The two groups were compared with respect to BMI, lipid profile, blood pressure, insulin resistance, serum lipids, insulin, glucose, leptin, high-sensitive C-reactive protein, free fatty acid and homeostatic model assessment of insulin resistance (HOMA-IR). Total 53.9 and 33.6% of patients with skin tags were overweight and obese, respectively. The frequency of hypertension 30.1%, dyslipidemia 59.3% and insulin resistance 21.2% were detected. HOMA-IR (P < 0.001) and serum glucose (P < 0.001), insulin (P = 0.002), high-sensitive C-reactive protein (P = 0.001), uric acid (P = 0.001), free fatty acid (P = 0.002), HbA1c (P < 0.001), total cholesterol (P = 0.018), LDL-cholesterol (P = 0.023), and triglyceride levels (P = 0.001) were higher in patients with skin tags than control group. Overweight and/or obesity, dyslipidemia, hypertension, insulin resistance and elevated high-sensitive C-reactive protein are seen in patients with skin tags. Skin tags may be a marker of increased risk of atherosclerosis and cardiovascular disease.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The metabolic profile in patients with skin tags

et al. 2009

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“…Ponadto stwierdza się zwiększoną ilość receptora EGF (EGF-R) w tkance włókniaków. Prawdopodobnie ich nadmierna ekspresja może być spowodowana wzrostem nieestryfikowanych kwasów tłuszczowych ze względu na hiperinsulinemię [17]. Należy również zaznaczyć, że hiperinsulinemia zwiększa produkcję androgenów jajnikowych oraz IGF-1 i 2 w wątrobie.…”

Section: Włókniaki a Insulinoopornośćunclassified

Skin tags as a symptom of metabolic disorders

Owczarczyk‐Saczonek¹,

Placek²

2016

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Przegląd Dermatologiczny 2016/3 STRESZCZENIEWłókniaki miękkie są zaliczane do nowotworów łagodnych. Stwierdza się je głównie na skórze szyi, powiek, w okolicach pachowych i w pachwinach. Mają postać uszypułowanych, miękkich guzków. Ich występowanie wiąże się z otyłością, insulinoopornością, lipidemią aterogenną, czyli cechami zespołu metabolicznego. Są objawem wskazującym na zwiększone ryzyko rozwoju miażdżycy. Za czynniki wyjaśniające ich powstawanie uznaje się stymulację receptorów na keratynocytach i fibroblastach przez leptynę i insulinooporność towarzyszącą otyłości (IGF-1), a także przez androgeny i estrogeny, których gospodarka ulega zaburzeniu w otyłości. Dodatkowo receptory te są pobudzane przez tryptazę uwalnianą z komórek tucznych w wyniku urazów mechanicznych. Prawdopodobnie rolę kofaktorów odgrywają HPV. Piśmiennictwo dermatologiczne nie poświęca zbyt wiele miejsca tej tematyce, dlatego zamiarem autorów jest zwrócenie uwagi specjalistom naszej dziedziny na związek pomiędzy występowaniem włókniaków a rozwojem zaburzeń metabolicznych. ABSTRACTSkin tags are classified as benign lesions. They occur mainly on the skin of the neck, eyelids, armpits, and groin as pedicles and soft nodules. Their occurrence is associated with obesity, insulin resistance, atherogenic lipidemia, and metabolic syndrome, as well as increased risk of atherosclerosis. In the pathogenesis factors which are impaired in obesity, such as leptin, insulin resistance associated with obesity (IGF-1), androgens and estrogens believed to stimulate the receptors on keratinocytes and fibroblasts to grow, may play a role. In addition, these receptors are stimulated by tryptase released from the mast cells by mechanical injuries. Probably HPV plays a role as a cofactor. The dermatological literature does not provide much information about this subject, so the authors draw attention to the link between the presence of skin tags and the development of metabolic disorders. SŁOWA KLUCZOWE:otyłość, insulinooporność, włókniaki.

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Common Benign and Malignant Skin Lesions

McFerren

Leffell²

2011

Principles and Practice of Geriatric Surgery

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Insulin Resistance and Skin Tags

Cited by 40 publications

References 6 publications

The metabolic profile in patients with skin tags

The metabolic profile in patients with skin tags

Skin tags as a symptom of metabolic disorders

Common Benign and Malignant Skin Lesions

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