Insulin resistance and metabolic syndrome in primary gout: relation to punched‐out erosions

Gheita, Tamer A.; El-Fishawy, Hussein S.; Nasrallah, M. M.; Hussein, Hanan

doi:10.1111/1756-185x.12007

Cited by 22 publications

(6 citation statements)

References 19 publications

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“…Following a data analysis performed on data from 517 participants in the Bogalusa Heart Study, Muntner et al (67) suggested that an elevated body mass index was associated with high levels of uric acid. Furthermore, the BP analysis of the genes in the PPI network contained terms including 'hexose transmembrane transport' and 'regulation of insulin secretion', and the two groups involved in glycose metabolism have been reported to affect the transport of uric acid (68)(69)(70). The majority of the enriched BP terms were revealed to be involved in metabolite transports, which are closely associated with urate transport.…”

Section: Discussionmentioning

confidence: 99%

Unraveling the genetic causes in large pedigrees with gout by whole‑exome sequencing

et al. 2020

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Gout is a common type of inflammatory arthritis that is clinically and genetically heterogeneous. The genetic aetiology remains unclear, and mainly relies on previous genome-wide association studies focused on sporadic cases. The present study aimed to identify the genetic basis of gout in three families using whole-exome sequencing (WES). WES was performed in the probands, and family members were involved in the co-segregation analysis. In total, three deleterious rare or novel missense mutations were identified in ATP-binding cassette super-family G member 2 (ABCG2), protein kinase CGMP-dependent 2 (PRKG2) and adrenoceptor β3 (ADRB3) genes in three different families. In addition, certain gout-associated candidate genes were revealed to be shared among the co-expression and protein-protein interaction (PPI) networks of ABCG2, PRKG2 and ADRB3. Furthermore, the disease ontology analysis of the genes present in the co-expression network exhibited significant (P<0.05) enrichment in hyperuricemia, gout, cardiovascular system disease and metabolic disease. In addition, genes involved in the PPI network were significantly enriched in the purine nucleoside monophosphate biosynthetic process, urate transport and biological processes associated with glycose metabolism. Collectively, to the best of our knowledge, the present study was the first to use WES to identify three candidate rare or novel deleterious mutations in three families with gout. The present results provided novel insights that may improve the current understanding of the molecular genetic basis underlying gout. Importantly, the present results may facilitate the improvement of clinical diagnosis and the development of novel personalized therapies.

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Section: Discussionmentioning

confidence: 99%

Unraveling the genetic causes in large pedigrees with gout by whole‑exome sequencing

et al. 2020

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“…For example, Gheita et al . demonstrated that bone erosion was more prevalent in gout patients with metabolic syndrome compared with those without metabolic syndrome [ 27 ]. However, there were no differences in the frequency of bone erosion at the affected joints in individuals with and without VFO in the current study (data not shown).…”

Section: Discussionmentioning

confidence: 99%

Visceral fat obesity is highly associated with primary gout in a metabolically obese but normal weighted population: a case control study

Lee¹,

Lee²,

Lee³

et al. 2015

Arthritis Res Ther

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IntroductionGout is a chronic inflammatory disease the development of which is associated with obesity-induced metabolic abnormalities. However, a substantial number of non-obese patients (body mass index [BMI] <25 kg/m2) also develop gout in Korea. It was suggested that accumulation of visceral fat rather than subcutaneous fat is associated with metabolic abnormalities and hyperuricemia in patients with gout; therefore, we hypothesized that visceral fat accumulation was increased in non-obese gout patients.MethodsOne hundred and three male patients with primary gout and 204 age-matched healthy controls who attended a health check-up examination were recruited after the review of medical charts. The visceral fat area (VFA) was measured using the bioelectrical impedance analysis (BIA) method, and a VFA >100 cm2 was defined as visceral fat obesity (VFO). The frequency of VFO was compared in patients and control groups. The frequencies of metabolic syndrome and related parameters were also investigated.ResultsBMI, waist circumference, total fat mass, serum triglycerides, and serum glucose levels were significantly greater in patients compared with controls. VFA and the prevalence of VFO was increased in gout patients compared with controls. There were positive correlations between VFA and serum triglyceride levels and serum glucose levels. Multivariate regression analysis revealed that VFO is an independent risk factor for gout (odds ratio 2.488, 95% confidence interval 1.041–4.435). In non-obese subgroup analyses (gout patients, n = 38; healthy controls, n = 150), VFA (98.7 ± 19.3 vs. 91.0 ± 16.7, P = 0.016) and the frequency of VFO (47.4 vs. 27.3%, P = 0.017) remained significantly higher in gout patients. There was no difference in either BMI or total fat mass between patients and controls in the non-obese subgroup. The prevalence of metabolic syndrome in patients with gout was 31.7% (33/104), compared with 13.2% (5/38) in the non-obese subgroup according to modified ATP III criteria.ConclusionVFO, measured using BIA, is observed more frequently in patients with primary gout compared with healthy controls, even in non-obese individuals. Therefore, VFO might more properly represent metabolic derangements in patients with gout than general obesity.

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“…Nowadays, the incidence of hyperuricemia is increasing. Hyperuricemia is closely related to hypertension, atherosclerosis, insulin resistance and kidney disease, which seriously affects health [63][64][65][66]. Drugs usually used to treat hyperuricemia have some side effects that may affect the health of the body.…”

Section: Xanthine Oxidase Inhibitory Peptidementioning

confidence: 99%

Bioactive Peptides from Walnut Residue Protein

Guo

Chi

et al. 2020

Molecules

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Walnut residue is a kind of high-quality plant protein resource. The bioactive peptide prepared from walnut residue has excellent health care functions such as antioxidation and antihypertensive activity, but at present, walnut residue is often regarded as waste or low value feed, fertilizer and other materials. The uneconomical use of walnut residue has hindered the development of the walnut industry to some extent. Effective utilization of walnut residue protein to develop bioactive peptides and other products is of great significance to realize the comprehensive utilization of walnut residue, improve the added value of by-products, and change the current low utilization rate of walnut residue. In this paper, the preparation, purification and structure identification of walnut protein bioactive peptides are reviewed, and different functional walnut active peptides (WBPs) are introduced. The potential effects of these bioactivities on human health and their different uses in food, medicine and other industries are discussed. The purpose is to provide reference information for the effective utilization of walnut residue resources and the development of walnut industry.

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Insulin resistance and metabolic syndrome in primary gout: relation to punched‐out erosions

Abstract: The level of SUA is closely related to IR in patients with and without MetS. There is an association of the severity of gout and presence of MTP erosions to IR. Metabolic syndrome forms an important marker for those who develop more punched-out erosions.

Cited by 22 publications

References 19 publications

Unraveling the genetic causes in large pedigrees with gout by whole‑exome sequencing

Unraveling the genetic causes in large pedigrees with gout by whole‑exome sequencing

Visceral fat obesity is highly associated with primary gout in a metabolically obese but normal weighted population: a case control study

Bioactive Peptides from Walnut Residue Protein

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