Insulin Resistance and Its Association with Metabolic Syndrome in Korean Children

Cho, Jinkyung; Hong, Haeryun; Park, Soo-Hyun; Kim, Shinuk; Kang, Hyunah

doi:10.1155/2017/8728017

Cited by 31 publications

(25 citation statements)

References 23 publications

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“…In other words, the presence of allele A is associated with a more significant deposit of fat, which is related to a higher number of cardio-metabolic complications [37]. This fact is explained by the increase in adipose tissue, which is associated with higher insulin resistance (IR) and represents the primary physiopathological mechanism of MetS [38]. Our results have shown that IR increases significantly between the different genotypes, being higher in AA (β = 1.010, p < 0.001) [25].…”

Section: Discussionmentioning

confidence: 99%

Association between the FTO SNP rs9939609 and Metabolic Syndrome in Chilean Children

et al. 2021

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Background: The increasing prevalence of obesity in children has raised the incidence of Metabolic Syndrome (MetS) in this age group. Given the short- and long-term health impact of MetS, it is essential to prevent its onset by detecting its main triggers. Besides, genetic factors play an essential role in influencing which individuals within a population are most likely to develop obesity in response to a particular environment. In this regard, a common variation in the FTO gene is reproducibly associated with BMI and obesity from childhood and the genetic load has been linked to several cardiovascular risk factors, highlighting the FTO single nucleotide polymorphism (SNP) rs9939609. Therefore, this study aimed to establish the relationship between the FTO SNP rs9939609 and MetS. Methods: A cross-sectional study was carried out on 220 children from the Biobío region (Chile). MetS diagnosis was established through the modified Cook criteria, using prevalence ratios, COR curves, and linear regressions to determine its association with MetS and its components. Results: The prevalence of MetS was significantly increased among carriers of the risk allele (A): TT, 20.2%; TA, 25.4%; AA, 44.7% (p = 0.006). Also, the presence of A was associated with altered MetS-related variables. Conclusions: The FTO SNP rs9939609 was associated with a raised prevalence of MetS among A allele carriers, and was higher in the homozygous genotype (AA).

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Section: Discussionmentioning

confidence: 99%

Association between the FTO SNP rs9939609 and Metabolic Syndrome in Chilean Children

et al. 2021

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“…In addition, abundant clinical and epidemiologic evidence has demonstrated a close linkage between IR and hypertension via enhanced salt absorption in the kidney, activation of the sympathetic nervous system, and alteration in vascular resistance (see reviewed [ 33 ]). Findings suggest that IR is significantly associated with the clustering of MetS risk factors [ 34 , 35 , 36 , 37 ], and IR is considered central to the pathophysiology of cardiometabolic diseases.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Insulin Resistance in the Hungarian General and Roma Populations as Defined by Using Data Generated in a Complex Health (Interview and Examination) Survey

Ádány

Pikó

Fiatal

et al. 2020

IJERPH

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Data mainly from one-off surveys clearly show that the health of Roma, the largest ethnic minority of Europe, is much worse than that of the general population. However, results from comprehensive exploratory studies are missing. The aim of our study was to create a complex database for comparative and association studies to better understand the background of the very unfavourable health of Roma, especially the high burden of cardiometabolic diseases. A three-pillar (questionnaire-based, physical and laboratory examinations) health survey was carried out on randomly selected samples of the Hungarian general (HG, n = 417) and Roma (HR, n = 415) populations, and a database consisting of more than half a million datapoints was created. Using selected data, the prevalence rates of metabolic syndrome (MetS) and of its components were determined, and to estimate the risk of insulin resistance (IR), surrogate measures (the homeostasis model assessment of insulin resistance index, quantitative insulin sensitivity check index, McAuley and TyG indices and the TG/HDL-C ratio) were calculated. Receiver operating characteristic curve analysis and Youden’s method were used to define the optimal cut-off values of each IR index. The prevalence of MetS was very high in both study populations (HG: 39.8%, HR: 44.0%) with no statistically significant difference between the two groups in females or males. The prevalence of MetS showed a very marked increase in the HR 35–49 years age group. Among surrogate measures, the TyG index showed the greatest power for predicting IR/MetS at a cut-off value of 4.69 (77% sensitivity, 84% specificity) and indicated a 42.3% (HG) and 40.5% (HR) prevalence of IR. The prevalence of MetS and IR is almost equally very unfavourable in both groups; thus, the factors underlying the high premature mortality burden of Roma should be further clarified by investigating the full spectrum of risk factors available in the database, with a special focus on the access of Roma people to preventive and curative health services.

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“…Considerando que el SM se caracteriza por presentar alteraciones en el metabolismo de los hidratos de carbono (aumento de glucosa >100 mg/dl) y los lípidos (triglicéridos >150 mg/dl, HDL < 40 mg/dl en hombres y < 50 mg/dl en mujeres), nuestro estudio mostró que los pacientes con SM+ presentan alteraciones metabólicas en comparación con los SM-. Este mismo comportamiento se ha observado en estudios previos [29][30][31] .…”

Section: Discussionunclassified

El papel de la amilina en la función de la célula B pancreática en pacientes con síndrome metabólico

Plata-Corona¹,

Lara-Solis²,

Pérez-Fuentes³

et al. 2020

RME

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Insulin Resistance and Its Association with Metabolic Syndrome in Korean Children

Cited by 31 publications

References 23 publications

Association between the FTO SNP rs9939609 and Metabolic Syndrome in Chilean Children

Association between the FTO SNP rs9939609 and Metabolic Syndrome in Chilean Children

Prevalence of Insulin Resistance in the Hungarian General and Roma Populations as Defined by Using Data Generated in a Complex Health (Interview and Examination) Survey

El papel de la amilina en la función de la célula B pancreática en pacientes con síndrome metabólico

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