Insulin resistance and changes in plasma concentration of TNF<i>α</i>, IGF1, and NEFA in dogs during weight gain and obesity

Gayet, Constance; Bailhache, Edwige; Dumon, H.; Martin, Lucile; Siliart, Brigitte; Nguyen, Patrick

doi:10.1111/j.1439-0396.2003.00473.x

Cited by 78 publications

(57 citation statements)

References 51 publications

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“…However, this is not consistently observed [34] and may be a result of protein restriction [35] . Plasma IGF-1 was progressively increased during 7 months of overfeeding period in dogs [36] , but we did not detect changes in IGF-1 in response to acute overfeeding in this cohort. This study suggests that changes in markers of hepatic insulin resistance precede changes in hepatokines, IGF-1, SEPP1 and ANGPTL6.…”

Section: Discussioncontrasting

confidence: 76%

Acute Overfeeding Does Not Alter Liver or Adipose Tissue-Derived Cytokines in Healthy Humans

Chen¹,

Liu²,

Thompson³

et al. 2016

Ann Nutr Metab

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Background/Aims: The secretions of liver-derived cytokines angiopoietin-like 6, insulin-like growth factor 1, selenoprotein-P and C-reactive protein and adipokines, adiponectin and monocyte chemoattractant protein-1 are altered in obese individuals, and they directly induce insulin resistance in both cellular and animal models. This study is aimed at examining the effects of acute overnutrition on these cytokines in healthy individuals, and identifying association with markers of insulin resistance. Methods: Thirty-one young healthy individuals (10 men, body mass index (BMI) 22.4 ± 2.7; 21 women, BMI 23.3 ± 4.9) were enrolled for the study. Metabolic assessments were done 3 days after an energy balanced diet (30% fat) and 3 days of a high-fat overfeeding diet (+1,250 kcal/day, 45% fat), and the assessments included the fasting body weight and blood samples to analyze the selected cytokines and evaluate the insulin sensitivity by a hyperinsulinemic euglycemic clamp (80 mU/m²/min). Results: Three days of overfeeding increased the body weight, fasting glucose and insulin, and thus the homeostasis model assessment of insulin resistance. However, there were no changes in peripheral insulin sensitivity, or in the circulating cytokines assessed. Conclusions: The hepatokines and adipokines assessed were not acutely sensitive to overnutrition in healthy individuals, despite increases in markers of hepatic insulin resistance.

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Section: Discussioncontrasting

confidence: 76%

Acute Overfeeding Does Not Alter Liver or Adipose Tissue-Derived Cytokines in Healthy Humans

Chen¹,

Liu²,

Thompson³

et al. 2016

Ann Nutr Metab

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show abstract

“…Indeed, low 22 and high IGF-1 serum levels have been associated with insulin sensitivity in animal models and humans. 23,24 Studies of the evolution of body weight with obesity, its cluster of common risk factors and IGF-1 (plasma concentrations and synthesis) during sexual maturation would be helpful to understand childhood obesity and its consequences. This would involve longitudinal studies with a strict control of food intake from childhood to adulthood.…”

Section: And Inmentioning

confidence: 99%

Childhood obesity and insulin resistance in a Yucatan mini-piglet model: putative roles of IGF-1 and muscle PPARs in adipose tissue activity and development

et al. 2005

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OBJECTIVE:To explore metabolic and cellular modifications induced during childhood obesity, in a novel animal model of obese mini-piglets. DESIGN: A total of 10 four-month old Yucatan mini-pigs were followed from prepuberty to adulthood. Animals were divided into two groups. The first one had been overfed (OF) a western-type diet and the second one had been normally fed a control recommended human-type diet (NF). MEASUREMENTS: Plasma insulin-like growth factor 1 (IGF-1), insulin, leptin, nonesterified fatty acids, triglycerides (TGs) and glucose were determined at sexual maturity and at young adulthood. Quantitative gene expressions of peroxysome-proliferatoractivated receptors (PPARs), glucose transporter 4, insulin receptor, IGF-1, leptin and interleukin-6 (IL-6) in skeletal muscle, adipose tissue and liver were also measured at both stages. Adult insulin sensitivity was measured via euglycaemichyperinsulinaemic clamps. RESULTS: Increased body weight in adult OF pigs was associated with increased body size and low insulin sensitivity. Sexually mature OF pigs had higher IGF-1 plasma concentrations than their lean littermates (Po0.05). In the OF group, TGs and glucose were both decreased (Po0.05). Muscle PPARg and a in OF pubescent pigs as compared to NF pigs were 11 times higher and 20 times lower, respectively (Po0.01). CONCLUSION: Obesity and insulin resistance induced by overfeeding mini-pigs during development and puberty were not associated with the cluster of metabolic modifications frequently observed in their adult littermates. Increased IGF-1 concentrations and modifications of skeletal muscle PPAR (a and g) expressions may help the young obese pig to partially regulate its glycaemia and triglyceridaemia through an increase of fat mass, which maintains its high insulin sensitivity.

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“…These authors did not detect hyperglycemia in obese dogs but ob- [30]. Only one of the eight obese dogs studied had hyperinsulinemia, which means, insulin greater than 40 μU/mL [27]. In spite of this, all dogs showed a reduction of about 22% of insulinemia after weight loss, similar to the findings from [7].…”

Section: P N De Marchi Et Al Open Journal Of Veterinary Medicinementioning

confidence: 66%

Metabolic Parameters in Obese Dogs Undergoing to the Diet with Calorie Restriction

Marchi¹,

Cardoso²,

Fagnani³

et al. 2018

OJVM

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Currently, canine obesity is a worldwide problem and is based on the excessive deposit of fat tissue, which plays an important role as a store of energy and endocrine organ. This study aimed to compare the values of systolic blood pressure, serum chemistry profile and glucose metabolism in eight obese dogs without endocrine diseases before and after 16 weeks of a weight loss program. A statistical difference was noticed in the serum levels of alkaline phosphatase, gamma glutamyl transferase, glucose, cholesterol and insulin, before and after the program. Besides, there was a statistical difference between the moments in systolic blood pressure, body weight and body condition scale. Therefore, it was concluded that the use of a diet rich in fiber and protein is suitable for performing weight loss and obese dogs undergoing a weight loss program presented a significant reduction in blood pressure, blood glucose, insulin, blood cholesterol, serum activity of alkaline phosphatase and gamma glutamyl transferase.

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Insulin resistance and changes in plasma concentration of TNFα, IGF1, and NEFA in dogs during weight gain and obesity

Cited by 78 publications

References 51 publications

Acute Overfeeding Does Not Alter Liver or Adipose Tissue-Derived Cytokines in Healthy Humans

Acute Overfeeding Does Not Alter Liver or Adipose Tissue-Derived Cytokines in Healthy Humans

Childhood obesity and insulin resistance in a Yucatan mini-piglet model: putative roles of IGF-1 and muscle PPARs in adipose tissue activity and development

Metabolic Parameters in Obese Dogs Undergoing to the Diet with Calorie Restriction

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