Insulin resistance affects endothelium-dependent acetylcholine-induced coronary artery response

Inoue, Teruo; Matsunaga, Riichiro; Sakai, Yoshihiko; Yaguchi, Isao; Takayanagi, Kunio; Morooka, Shigenori

doi:10.1053/euhj.1999.1872

Cited by 28 publications

(21 citation statements)

References 24 publications

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“…Our observations are in accordance with previous reports showing that insulin resistance may contribute to coronary endothelial dysfunction in both animals and humans. [34][35][36][37][38][39][40][41] Characterization of the molecular mechanisms responsible for the impaired action of insulin action and the endothelialmediated vascular responses to the metabolic derangements induced by insulin resistance is of considerable clinical interest. At the cellular level, the signaling pathways of insulin-mediated glucose uptake and that of NO production are common in part.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Coronary Endothelial Function by Catheter-Type NO Sensor in High-Fat-Diet-Induced Obese Dogs

Kume

Kawamoto

Okura

et al. 2009

Circ J

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Circ J 2009; 73: 562 -567 n the coronary circulation, endothelium-derived nitric oxide (NO) plays a fundamental role in the regulation of blood flow, exerting a tonic vasodilator influence at rest and with increasing myocardial metabolism. 1 The bioavailability of NO is thought to be diminished in subjects with various coronary risk factors and/or pathologic conditions, such as aging, gender, obesity, hypertension, hypercholesterolemia, diabetes mellitus, and metabolic syndrome. [2][3][4][5][6][7][8][9][10][11][12] Thus, endothelial dysfunction, characterized by decreased bioavailability of NO, has been recognized as a predictor of cardiovascular risk and outcome. [13][14][15][16][17] Editorial p 434Coronary endothelial function is most commonly assessed by intracoronary injection of acetylcholine (ACh), which stimulates release of NO and dilates the coronary arteries, but in patients with coronary endothelial dysfunction, infusion of ACh results in paradoxical vasoconstriction. [18][19][20][21][22] This method is widely used in diagnosing coronary vasospastic angina. 17,23 However, there are still many uncertainties about the bioavailability of NO and the precise dynamics of NO have not been investigated. In order to evaluate both endothelial function and the bioavailability of NO in the coronary circulation, direct measurement of the NO concentration in the coronary circulation would be of great value. Recently, we developed a catheter-type NO sensor and demonstrated its validity for in-vivo measurement of NO in the coronary circulation. [24][25][26][27] The purpose of this study was to evaluate the influence of a high-fat diet on the bioavailability of NO by using the catheter-type NO sensor in vivo. MethodsThis study conformed to the Guideline for Care and Use of Laboratory Animals published by the National Institutes of Health (NIH publication No. 85-23, revised 1985) and was conducted under protocols approved by the Kawasaki Medical School Animal Care and Use Committee. High-Fat DietMongrel dogs (n=8) were assigned to either a control group (n=3) that received a regular diet (60 kcal · kg -1 · day -1 ) for 8 months or a high-fat-diet group (n=5; MANINE i/d dryTM, Hill's Nutrition Diet Inc, USA: 60 kcal · kg -1 · day -1 + lard 60 kcal · kg -1 · day -1 ) for 8 months. 28 Catheter-Type NO SensorThe NO sensor (amiNO-700 XL, Innovative Instruments, Tampa, FL, USA; 700 μm in diameter at the tip) was mounted in a 4Fr catheter (1,200 mm long; Hirakawa Hewtech, Tokyo, Japan) and fixed with silicon adhesive. The oxidative current of NO was monitored continuously. (Received August 24, 2008; revised manuscript received October 20, 2008; accepted November 5, 2008; released online February 3, 2009 (n=5) were fed a high-fat diet (120 kcal · kg -1 · day -1 ) for 8 months, then endothelial function was assessed by the change in NO concentration induced by acetylcholine (ACh) (∆NO). Simultaneously, average peak velocity (APV) was obtained by Doppler guide wire. Although fasting plasma glucose levels did not change a...

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Section: Discussionmentioning

confidence: 99%

Evaluation of Coronary Endothelial Function by Catheter-Type NO Sensor in High-Fat-Diet-Induced Obese Dogs

Kume

Kawamoto

Okura

et al. 2009

Circ J

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“…It has also been shown that the endothelium-dependent response of normal coronary arteries may be blunted by IR, thereby leading to coronary vascular endothelial dysfunction [4]. Hyperinsulinemia or IR has been emphasized as a coronary risk factor [5,6].…”

Section: Introductionmentioning

confidence: 99%

Discordance between insulin resistance and metabolic syndrome: features and associated cardiovascular risk in adults with normal glucose regulation

et al. 2006

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“…18,33,35,36 In particular, insulin resistance with dyslipidemia characterized by postprandial hyperlipidemia is part of the so-called metabolic syndrome, 35,36 and has been reported to be an indicator of coronary and systemic artery atherosclerosis. 37,38 RLP-C elevation after oral glucose ingestion was observed in patients with impaired glucose tolerance accompanied by insulin resistance. 39 They may be a close association of insulin resistance with postprandial RLP-C elevation in the present study population, but as we did not assess insulin resistance, the mechanism of postprandial RLP-C elevation remains uncertain.…”

Section: Fat-loading and Postprandial Hyperlipidemiamentioning

confidence: 99%

Postprandial Elevation of Remnant Lipoprotein Leads to Endothelial Dysfunction

Funada

Sekiya

Hamada

et al. 2002

Circ J

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Insulin resistance affects endothelium-dependent acetylcholine-induced coronary artery response

Abstract: These results suggest that there is an association between high insulin resistance and coronary vascular endothelial cell dysfunction, and that insulin resistance may be an indicator of early stage coronary artery atherosclerosis not detectable by angiography.

Cited by 28 publications

References 24 publications

Evaluation of Coronary Endothelial Function by Catheter-Type NO Sensor in High-Fat-Diet-Induced Obese Dogs

Evaluation of Coronary Endothelial Function by Catheter-Type NO Sensor in High-Fat-Diet-Induced Obese Dogs

Discordance between insulin resistance and metabolic syndrome: features and associated cardiovascular risk in adults with normal glucose regulation

Postprandial Elevation of Remnant Lipoprotein Leads to Endothelial Dysfunction

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