Insulin nanoparticle preparation and encapsulation into poly(lactic-co-glycolic acid) microspheres by using an anhydrous system

Han, Yadong; Tian, Huayu; He, Pan; Chen, Xuesi; Jing, Xiabin

doi:10.1016/j.ijpharm.2009.05.021

Cited by 45 publications

(27 citation statements)

References 43 publications

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“…The results indicate that the insulin structure was only slightly altered after association with the silica matrix ( Table 8). The two samples have almost the same α-helix content (41 AE 1 %), which is consistent with previously published studies [15,49,50]. The increase in β-sheet content (from 27 % to 29 %) can be explained by the intermolecular β-sheet formation, in this case, representing the small amount of insulin spread on the surface of the silica particles [15].…”

Section: Loading Procedure: Encapsulationsupporting

confidence: 90%

Glass-Ceramics: Fundamental Aspects Regarding the Interaction with Proteins

Gruian¹,

Vanea²,

Steinhoff³

et al. 2015

Handbook of Bioceramics and Biocomposites

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Section: Loading Procedure: Encapsulationsupporting

confidence: 90%

Glass-Ceramics: Fundamental Aspects Regarding the Interaction with Proteins

Gruian¹,

Vanea²,

Steinhoff³

et al. 2015

Handbook of Bioceramics and Biocomposites

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“…The encapsulation of drug molecules within the "Trojan horse" nanosystems is the key in harnessing the power of nanotechnology for development of better anti-cancer therapeutics [2]. Because of this, the determination of the encapsulation efficiency (EE) which is defined as the percentage of drug molecules successfully entrapped within the NPs is regarded as a key step in characterizing the quality of the nanoformulations [3,4].…”

Section: Introductionmentioning

confidence: 99%

Development and Validation of a Method for Determination of Encapsulation Efficiency of CPT-11/DSPE-mPEG2000 Nanoparticles

Li¹,

Li²

2016

Med chem (Los Angeles)

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“…The untreated cells were used as a negative control. Anti-proliferation activity (%) was calculated by the following equation (Bouquet et al, 2009;Han et al, 2009): Cell viability ð%Þ ¼ ðAbsorbance treated cells =Absorbance untreated cells Þ Â 100…”

Section: Anti-proliferation By the Srb Assaymentioning

confidence: 99%

Anti-proliferative and matrix metalloproteinase-2 inhibition of Longkong (Lansium domesticum) extracts on human mouth epidermal carcinoma

Manosroi

Chankhampan²,

Manosroi

et al. 2013

Pharmaceutical Biology

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Context: Longkong [Lansium domesticum Corr. (Meliaceae)] is a popular tropical plant producing economic edible fruits found mainly in Southeast Asia. However, limited information is available concerning anticancer activity of Longkong. Objective: To investigate anticancer activities in human mouth epidermal carcinoma (KB) of Longkong extracts. Materials and methods: Various parts of Longkong which was collected from Northern and Eastern of Thailand were extracted by the hot and cold processes using water, chloroform, and methanol. The extracts were tested for anti-oxidative activities and anti-proliferation as well as matrix metalloproteinase inhibition on KB cells. Results: The hot water extract of seeds from Northern region (NSEWH), the cold water extract of old leaves from Northern region (NOLWC), and the hot chloroform extract of young leaves from Eastern region (EYLCH) showed the highest free radical scavenging, metal ion chelating, and lipid peroxidation inhibition with SC 50 , MC 50 and IPC 50 values of 0.34 AE 0.03, 0.47 AE 1.60 and 0.86 AE 0.31 mg/ml, respectively. The hot and cold chloroform extract of young fruits from Northern region (NYFCH and NYFCC) exhibited anti-proliferation effect against KB cells with IC 50 values of 603.45 AE 55.35 and 765.06 AE 46.19 mg/ml, respectively. NYFCC exhibited the highest pro-and active MMP-2 inhibition at 53.03 AE 2.65 and 31.30 AE 0.43%, more than all tested standard anticancer drugs except cisplatin. Discussion and conclusion: The cold chloroform extract of young fruits from Northern region appeared to contain anticancer active compounds against KB cells because of its high anti-proliferation and MMP-2 inhibition activities.

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Insulin nanoparticle preparation and encapsulation into poly(lactic-co-glycolic acid) microspheres by using an anhydrous system

Cited by 45 publications

References 43 publications

Glass-Ceramics: Fundamental Aspects Regarding the Interaction with Proteins

Glass-Ceramics: Fundamental Aspects Regarding the Interaction with Proteins

Development and Validation of a Method for Determination of Encapsulation Efficiency of CPT-11/DSPE-mPEG2000 Nanoparticles

Anti-proliferative and matrix metalloproteinase-2 inhibition of Longkong (Lansium domesticum) extracts on human mouth epidermal carcinoma

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