Insulin Mucoadhesive Liposomal Gel for Wound Healing: a Formulation with Sustained Release and Extended Stability Using Quality by Design Approach

Dawoud, Marwa H. S.; Yassin, Ghada E.; Ghorab, Dalia; Morsi, Nadia M.

doi:10.1208/s12249-019-1363-6

Cited by 39 publications

(30 citation statements)

References 40 publications

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“…Dawoud et al (2019) explored the effect of insulin mucoadhesive liposomal gel on patients with chronic wounds in different parts of the body. 43 Patients were randomly assigned to receive treatment with insulinloaded liposomal chitosan gel (n=10) or liposomal Table 2.…”

Section: Clinical Studiesmentioning

confidence: 99%

<p>Effects of Topical Insulin on Wound Healing: A Review of Animal and Human Evidences</p>

Wang

2020

DMSO

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Wound healing is a complex biological process that repairs damaged tissues and restores skin integrity. Insulin, a potent factor of wound healing, has been reported for nearly a century to induce rapid recovery of various wounds, as shown by numerous human and animal studies. Although many studies have addressed the healing effect of systemic insulin on burn wound, only few have investigated the efficacy of topical insulin. Thus, this study aimed to review evidence of the effects of topical insulin on wound healing, including on diabetic and non-diabetic wounds. The presented animal and clinical studies support that topical insulin improves wound healing through several mechanisms without causing side effects. Additionally, various wound dressings accelerate the wound healing with controlled and sustained delivery of bioactive insulin. Therefore, topical insulin has been appreciated in field of wound healing, and further studies are needed to improve our understanding of the role of insulin in the healing of various wounds.

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Section: Clinical Studiesmentioning

confidence: 99%

<p>Effects of Topical Insulin on Wound Healing: A Review of Animal and Human Evidences</p>

Wang

2020

DMSO

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“…Insulin-loaded liposomes included into a chitosan hydrogel demonstrated its efficacy in chronic wounds in patients, reducing the erythema and the time of wound duration. 135 Wang et al tried the liposomes using a model of diabetic rabbit with ischemic tissue. They topically administered adenosine triphosphate liposomes in the wounds and observed a faster wound closure than the control.…”

Section: Liposomes and Other Self-assembled Structuresmentioning

confidence: 99%

Nanotechnology Approaches in Chronic Wound Healing

Blanco-Fernandez

Castaño

Mateos‐Timoneda

et al. 2021

Advances in Wound Care

105

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The incidence of chronic wounds is increasing due to our aging population and the augment of people afflicted with diabetes. With the extended knowledge on the biological mechanisms underlying these diseases, there is a novel influx of medical technologies into the conventional wound care market. Recent Advances: Several nanotechnologies have been developed demonstrating unique characteristics that address specific problems related to wound repair mechanisms. In this review, we focus on the most recently developed nanotechnology-based therapeutic agents and evaluate the efficacy of each treatment in in vivo diabetic models of chronic wound healing. Critical Issues: Despite the development of potential biomaterials and nanotechnology-based applications for wound healing, this scientific knowledge is not translated into an increase of commercially available wound healing products containing nanomaterials. Future Directions: Further studies are critical to provide insights into how scientific evidences from nanotechnology-based therapies can be applied in the clinical setting.

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“…Through Franz diffusion cells, the insulin dispersion and the optimized formulation expressed a prolonged release of 6 h and up to 24 h, respectively [84]. The healing potential of insulin-containing liposomes was evaluated by the same group, which impregnated a chitosan gel with insulin-loaded liposomes and evaluated the clinical outcomes in non-diabetic patients [85]. Liposomal insulin in aqueous dispersion was stable for 6 months at 4 • C, and its release was sustained for 24 h. The clinical trial was coordinated in 15 patients over 8 months, in which liposomal insulin showed wound closure 16 times faster than the control group, with less erythema and no lowering blood sugar.…”

Section: Liposomesmentioning

confidence: 99%

Nanocarrier-Mediated Topical Insulin Delivery for Wound Healing

et al. 2021

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Wound care has been clinically demanding due to inefficacious treatment that represents an economic burden for healthcare systems. In Europe, approximately 7 million people are diagnosed with untreated wounds, leading to a cost between 6.000€ and 10.000€ per patient/year. In the United States of America, 1.5 million people over 65 years old suffer from chronic wounds. A promising therapeutic strategy is the use of exogenous growth factors because they are decreased at the wound site, limiting the recovery of the skin. Insulin is one of the cheapest growth factors in the market able to accelerate the re-epithelialization and stimulate angiogenesis and cell migration. However, the effectiveness of topical insulin in wound healing is hampered by the proteases in the wound bed. The encapsulation into nanoparticles improves its stability in the wound, providing adhesion to the mucosal surface and allowing its sustained release. The aim of this review is to perform a standing point about a promising strategy to treat different types of wounds by the topical delivery of insulin-loaded nanocarriers.

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Insulin Mucoadhesive Liposomal Gel for Wound Healing: a Formulation with Sustained Release and Extended Stability Using Quality by Design Approach

Cited by 39 publications

References 40 publications

<p>Effects of Topical Insulin on Wound Healing: A Review of Animal and Human Evidences</p>

<p>Effects of Topical Insulin on Wound Healing: A Review of Animal and Human Evidences</p>

Nanotechnology Approaches in Chronic Wound Healing

Nanocarrier-Mediated Topical Insulin Delivery for Wound Healing

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